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McCloskey Home Page | Medicinal Chemistry
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Abstract
| Curr Opin Biotechnol 1998 Feb;9(1):25-34. Applications of mass spectrometry to the characterization of oligonucleotides and nucleic acids. Crain PF, McCloskey JA. |
| Mass spectrometry-based techniques continue to undergo active development for applications to nucleic acids, fueled by methods based on electrospray and matrix-assisted laser desorption ionization. In the past two years, notable advances have occurred in multiple interrelated areas, including sequencing techniques for oligonucleotides, approaches to mixture analysis, microscale
sample handling and targeted DNA assays, and improvements in instrumentation for greater sensitivity and mass resolution.
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