A.  Positions and Honors

Positions and Employment
1978-80         NIH Postdoctoral Fellow, University of Hawaii
1980              Postdoctoral Fellow, University of Illinois
1980-83         Assistant Professor, University of Connecticut
1983-86         Adjunct Assistant Professor, Department of Chemistry, University of Utah
1983-86         Assistant Professor, Department of Medicinal Chemistry, College of Pharmacy, University of Utah
1986-91         Adjunct Associate Professor, Department of Chemistry, University of Utah
1986-91         Associate Professor, Department of Medicinal Chemistry, College of Pharmacy, University of Utah
1991-             Adjunct Professor, Department of Chemistry, University of Utah
1991              Professor, Department of Medicinal Chemistry, College of Pharmacy, University of Utah
2002 -            Chairman, Department of Medicinal Chemistry, College of Pharmacy, University of Utah

Honors and Distinctions
1978-80           National Institutes of Health Postdoctoral Fellow
1981                University of Connecticut Summer Faculty Fellow
1985-89           Alfred P. Sloan Foundation Fellow
1987-92           National Institutes of Health Research Career Development Award
2006                University of Utah Distinguished Mentor

National Public Service Activities and Committee Memberships
American Society of Pharmacognosy, Chairman, Awards and Funds Committee, 1985-88
American Society of Pharmacognosy, Chairman & Host, 1988 Annual Meeting
Member Bio-organic and Natural Products study section-NIH, 1989-1993 
Vice-President/President Elect, American Society of Pharmacognosy, 1990-91
Co-Chairman, Marine Natural Products Gordon Conference, 1990
President, American Society of Pharmacognosy, 1991-1992
Chairman, Marine Natural Products Gordon Conference, 1992
American Society of Pharmacognosy, Chair, Scientific Committee & Member, Local
Committee, 1993 Annual Meeting
American Society of Pharmacognosy, Chair, Personnel Committee, 1993-1996
NIH DRG Reviewers Reserve, 1993- Have served ad hoc on numerous study sections and site visit teams.
American Society of Pharmacognosy, Chair, Research Achievement Award Committee, 1998
Journal Editorial Boards:
            Journal of Natural Products                1999-present
            Philippine Journal of Science              1999-present
            Marine Drugs                                      2002-present
             

B.  Selected peer-reviewed publications (in chronological order).

(Publications selected from a total of 141)

Richardson, A.D.; Ireland, C.M. A profile of the in vitro antitumor activity of lissoclinolide Tox. App. Pharm. (2004) 195, 55-61.

Andersen, R.J.; Ireland, C.M.; Molinski, T.F.; Bewley, C.A.  Research Achievement Award-D. John Faulkner J. Nat. Prod. (2004) 67, 1239-51.

Jette, C.; Peterson, P.W.; Sandoval, I.T.; Manos, E.J.; Hadley, E.; Ireland, C.M.; Jones, D.A. The tumor suppressor adenomatous polyposis coli and caudal related homeodomain protein regulate expression of retinol dehydrogenase L. J. Biol. Chem. (2004) 279, 34397-405.

Bobzin, S.C.; Cardellina, J.H. 2nd; Gerwick, W.H.; Okuda, R.K.; Harper, M.K.; Ireland, C.M. Special issue in honor of D. John Faulkner and Paul J. Scheuer J. Nat. Prod. (2004) 67, 1201-3.

Ratnayake, A.S; Davis, R.A.; Harper, M.K.; Veltri, C.A.; Andjelic, C.D.; Barrows, L.R.; Ireland, C.M. Aurantosides G, H, and I: three new tetramic acid glycosides from a Papua New Guinea Theonella swinhoei. J. Nat. Prod. (2005) 68, 104-7.
Richardson, A.D., Aalbersberg, W.; Ireland, C.M. The patellazoles inhibit protein synthesis at nanomolar concentrations in human colon tumor cells. Anti-Cancer Drugs (2005) 16, 533-41.

Janso, J.E.; Bernan, V.S.; Greenstein, M.; Bugni, T.S.; Ireland, C.M. Penicillium dravuni, a new marine-derived species from an alga in Fiji. Mycologia (2005) 97, 444-53.

Dijoux, M.G.; Schnabel, P.C.; Hallock, Y.F.; Boswell, J.L.; Johnson, T.R.; Wilson, J.A.; Ireland, C.M.; van Soest, R.; Boyd, M.R.; Barrows, L.R.; Cardellina, J.H. 2nd  Antitumor activity and distribution of pyrroloiminoquinones in the sponge genus Zyzzya. Bioorg. Med. Chem. (2005) 13, 6035-44.
Chevallier, C.; Bugni, T.S.; Feng, X.; Harper, M.K.; Orendt, A.M.; Ireland, C.M. Tedanolide C: a potent new 18-membered ring cytotoxic macrolide isolated from the Papua New Guinea marine sponge Ircinia sp. J. Org.Chem. (2006) 71, 2510-13.

Alexander, M.D; Burkart, M.D; Leonard, M.S; Portonovo, P.; Liang, B.; Ding, X.; Joullié, M.M.; Gulledge, B.M.; Aggen, J.B.; Chamberlin, A.R.; Sandler, J.; Fenical, W.;J Cui,J.; Gharpure, S.J.; Polosukhin, A.; Zhang, H.R.; Evans, P.A.; Richardson, A.D.; Harper, M.K.; Ireland, C.M.; Vong, B.G.; Brady, T.P.; Theodorakis, E.A.; La Clair, J.J. A unified strategy for converting natural products into fluorescent probes ChemBioChem, (2006) 7, 409-16.

Ratnayake, A.S.; Bugni, T.S.; Veltri, C.A.; Skalicky, J.J.; Ireland, C.M. Chemical transformation of prostaglandin-A2: a novel series of C-10 halogenated, C-12 hydroxylated prostaglandin-A2 analogues Org Lett. (2006) 8, 2171-4.

Shelton, D.N.; Sandoval, I.T.; Eisinger. A.; Chidester, S.; Ratnayake, A.; Ireland, C.M.; Jones, D.A. Up-regulation of CYP26A1 in adenomatous polyposis coli-deficient vertebrates via a WNT-dependent mechanism: implications for intestinal cell differentiation and colon tumor development. Cancer Res. (2006) 66, 7571-7.

C.  Research Support

R01 CA36622-24 (Ireland) In no cost extension, this application requests renewal of this program.
12/01/06 – 11/31/2011                                                                                                                       
NIH/NCI                                                                     
Antineoplastic Agents from Marine Organisms
The major goals of this project are 1) to identify new structural classes of natural products produced by marine organisms and evaluate their potential as cancer chemotherapy agents and 2) to continue studies directed at development of new screening protocols for discovery of natural product antitumor agents.

U19 CA67786-12 (Ireland (PI)
09/08/1995 – 04/30/2010
NIH/NCI
Anticancer Agents from Unique Natural Product Sources
The major goals of this project are to discover and develop novel anticancer agents from a variety of natural products’ sources.

R03 TW06008-03 (Ireland)
08/15/2002 – 07/31/2006 In no cost extension.
Fogarty – FIRCA                                                                   
HIV and TB Screeningof PNG Marine Organisms                                                                
The major goal of this project is to develop a bioassay screening program for AIDS and TB at the University of Papua New Guinea to support discovery of new natural product anti-HIV and anti-TB agents from PNG marine organisms.

RSG-02-141-01-CNE  (Jones)
07/02/02 – 06/30/06
American Cancer Society      
Retinoid Biosynthesis in Colon Tumorgenesis
The major goals are to characterize the control of retinoid biosynthesis in the colon. 

5U01 TW006671-04 (Ireland)
05/01/2004-04/30/2008
U of U Salary Match for NIH - Fogarty ICBG
Conservation and Sustainable
Use of Biodiversity in PNG
The major goal of this project is to improve human health and well-being through an integrated set of programs dedicated to the assessment, conservation, and rational utilization of the flora and fauna of Papua New Guinea (PNG).

5 UO1 TWO06671-04 (Ireland)
09/25/2003 – 04/30/2008
Program 4      
NIH - Fogarty ICBG                                       
Conservation and Sustainable Use of Biodiversity in PNG. 
The major goal of this project is to improve human health and well-being through an integrated set of programs dedicated to the assessment, conservation, and rational utilization of the flora and fauna of Papua New Guinea (PNG).