Tim S. Bugni, Ph.D.

Department of Medicinal Chemistry
University of Utah
30 S. 2000 E. RM 307
Salt Lake City, UT 84112
(801) 581-4932, Tbugni@pharm.utah.edu

Education

2003- 2004                  Postdoctoral Fellow, Scripps Institution of Oceanography, UCSD  

1998 -  2003                Ph.D., Medicinal Chemistry, University of Utah
           
1992 - 1995                 B.S., Chemistry with Honors, Montana Tech of the University of Montana
           
1991                            Chemical Engineering (no degree), Montana State University

 Experience

2003 - 2004     Postdoctoral Fellow under the guidance of Professor William H. Fenical, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA                         Research focused on investigating new marine actinomycete genera as a source of pharmaceutical leads.

1999 - 2003     Graduate Research Assistant with Professor Chris M. Ireland, University of Utah, Salt Lake City, UT
                        Thesis research focused on investigating marine-derived fungi as a source of potential pharmaceutical leads with an emphasis on anticancer and antibiotic drug discovery.

2001-               Research intern (six weeks) at Wyeth research under the supervision of Dr. Valerie S. Bernan
                        Research included routine maintenance and fermentation of fungi, fungal fermentation studies, fungal genomic DNA isolation, taxonomic characterization of fungi using morphology and rDNA sequencing, feeding studies and metabolite analysis using LC-ion trap MS, and antimicrobial assays.

1995 – 1998    Research Specialist for Dr. Andrea A. Stierle, Montana Tech, Butte, MT
                        Research was focused on isolation and characterization of active metabolites from endophytic fungi.

1994 – 1995    Undergraduate Research with Professor Donald B. Stierle, Montana Tech, Butte, MT

Teaching Experience

Fall 2005-06    Lecturer, Fundamentals of Pharmaceutical Sciences, University of Utah

Fall 2005         Teaching Assistant, Introduction to Pharmaceutical Sciences, University of Utah

Fall 2000         Teaching Assistant, Introduction to Pharmaceutical Sciences, University of Utah

1993-1995       Teaching Assistant, General Chemistry, Montana Tech

Additional Education/Experience

• Waters Q-TOF Micro small molecule training course, Beverely, MA, April 24-27th, 2006

• 3-day training course with a Varian applications chemist on the use and administration of a 500 MHz INOVA NMR spectrometer, Scripps Institution of Oceanography, 2004

• 1-day course for operating a VG magnetic sector mass analyzer using CI and EI methods (Montana State University)

• 1-day course for operating a MALDI-TOF mass spectrometer (Montana State University)

• PADI open water diver certification
  
  

Honors

• Recipient of an American Society of Pharmacognosy Lynn Brady Student Travel Award, July 2002
  
  
• Chair of the Medicinal Chemistry student seminar committee, University of Utah, 2000-2001
  
  
• Recipient of NIH Biological Chemistry Training Fellowship, 1999-2000
  
  
• Recipient of travel award for a presentation at the Montana regional ACS meeting, 1998

Professional Associations

• Member of the American Society of Pharmacognosy
  
  

Publications

1. Stierle, D.B.; Stierle, A.A.; Bugni, T.; Loewen, G. Gloeolactone, a new epoxy lactone from a blue-green alga, J. Nat. Prod. (1998), 61, 251-252.

2. Stierle, A.A.; Stierle, D.B.; Bugni, T. Sequoiatones A and B: Novel antitumor metabolites isolated from a redwood endophyte, J. Org. Chem. (1999), 64, 5479-5484.

3. Bugni, T.S.; Abbanat, D.; Bernan, V.S.; Maiese, W.M.; Greenstein, M.; Van Wagoner, R.M.; Ireland, C.M. Yanuthones: Novel metabolites from a marine isolate of Aspergillus niger, J. Org. Chem. (2000), 65, 7195-7200.

4. Harper, M.K.; Bugni, T.S.; Copp, B.R.; James, R.D.; Lindsay, B.S.; Richardson, A.D.; Schnabel, P.C.; Tasdemir, D.; Van Wagoner, R.M.; Verbitski, S.M.; Ireland, C.M. Introduction to the chemical ecology of marine natural products, in Marine Chemical Ecology, McClintock, J. and Baker, B. Eds., CRC Press, 2001.

5. Stierle, A.A.; Stierle, D.B.; Bugni, T. Sequoiatones C-F, constituents of the redwood endophyte Aspergillus parasiticus, J. Nat. Prod. (2001), 64, 1350-1353.

6. Bugni, T.S.; Concepción, G.P.; Mangalindan, G.C.; Harper, M.K.; James, R.D.; Ireland, C.M.  p-Sulfooxyphenylpyruvic acid from the red racroalga, Ceratodictyon spongiosum and the sponge symbiont Sigmadocia symbiotica, Phytochem. (2002), 60, 361-363.

7. Torres, Y.R.; Bugni, T.S.; Berlinck, R.G.S.; Ireland, C.M.; Camargo, A.J.; Trsic, M.; Magalhães, A.; Ferreira, A.G.; da Rocha, R.M. Sebastianines A and B, novel biologically active pyridoacridine alkaloids from the Brazilian ascidian Cystodytes dellechiajei: Isolation and structure elucidation, J. Org. Chem. (2002), 67, 5429-5432.

8. Tasdemir, D.; Bugni, T.S.; Mangalindan, G.C.; Concepción, G.P.; Harper, M.K.; Ireland, C.M. New bromotryptophan derivatives from the Philippine marine sponge Smenospongia sp., Zeitschrift für Naturforschung, sec. C (2002), 57, 914-923.

9. Bugni, T.S.; Bernan, V.S.; Greenstein, M.; Janso, J.E.; Maiese, W.M.; Mayne, C.L.; Ireland, C.M. Brocaenols A-C:  Novel polyketides from a marine-derived Penicillium brocae., J. Org. Chem. (2003), 68, 2014-2017.

10. Bugni, T.S.; Bernan, V.S.; Greenstein, M.; Janso, J.E.; Maiese, W.M.; Mayne, C.L.; Ireland, C.M. Brocaenols A-C:  Novel polyketides from a marine-derived Penicillium brocae., J. Org. Chem. (2003), 68, 6846 (addition/correction).
    
    
11. Tasdemir, D.; Bugni, T.S.; Mangalindan, G.C.; Concepción, G.P.; Harper, M.K.; Ireland, C.M. Bisaboline type sesquiterpenes from a marine Didscus sponge, Turk. J. Chem., (2003), 27, 273-279.
    
    
12. Stierle, A.A.; Stierle, D.B.; Bugni, T. Sequoiamonascins A-D: Novel anticancer metabolites isolated from a redwood endophyte, J. Org. Chem., (2003), 68, 4966-4969.
    
    
13. Stierle, A.A.; Stierle, D.B.; Goldstein, E.; Parker, K.; Bugni, T.; Baarson, C.; Gress, J.; Blake, D.  A Novel 5-HT receptor ligand and related cytotoxic compounds from an acid mine waste extremophile, J. Nat. Prod., (2003); 66, 1097-1100.

14. Sandoval, I.S.; Bugni, T.S.; Davis, R.A.; Concepción, G.P.; Harper, M.K.; Ireland, C.M. Cytotoxic isoquinoline quinones from the genus Petrosia, Nat. Prod. Res., (2004), 18, 89-93.

15. Bugni, T.S.; Ireland, C.M.  Marine-derived Fungi:  A chemically and biologically diverse group of microorganisms, Nat. Prod. Reports, (2004), 21, 143-163.

16. Bugni, T.S.; Singh, M.P.; Chen, L.; Arias, D.; Harper, M.K.; Greenstein, M.; Maiese, W.M.; Concepción, G.P.; Mangalindan, G.C.; Ireland, C.M. Kalihinols from two Acanthella cavernosa sponges:  Inhibitors of bacterial folate biosynthesis, Tetrahedron, (2004), 60, 6981-6988.

17. Bugni, T.S.; Janso, J.E.; Williamson, R.T.; Feng, X.; Bernan, V.S.; Greenstein, M.; Carter, G.T.; Maiese, W.M.; Ireland, C.M.  Dictyosphaeric acids A and B:  New decalactones from an undescribed Penicillium sp. obtained from the alga Dictyosphaeria versluyii, J. Nat. Prod., (2004), 67, 1396-1399.

18. Janso, J.E.; Bugni, T.S.; Greenstein, M.; Ireland, C.M.; Bernan, V.S. Penicillium dravuni, a new marine-derived species from an alga in Fiji, Mycologia, (2005), 97, 444-453.

19. Chevallier, C.; Bugni, T.S.; Feng, X.; Harper, M.K.; Orendt, A.M.; Ireland, C.M. Tedanolide C: A potent new 18-membered-ring cytotoxic macrolide isolated from the Papua New Guinea sponge Ircinea sp., J. Org. Chem. (2006), 71, 2510-2513.

20. Ratnayake, A.S.; Bugni, T.S.; Veltri, C.A.; Skalicky, J.J.; Ireland, C.M. Chemical transformation of prostaglandin-A2: a novel series of C-10 halogenated, C-12 hydroxylated prostaglandin-A2 anlogues, Org. Lett. (2006), 8, 2171-2174.

21. Bugni, T.S.; Woolery, M.; Kauffman, C.A.; Jensen, P.R.; Fenical, W. New bohemamines from a marine-derived Streptomyces sp., J. Nat. Prod. (2006), Manuscript submitted.

22. Lira, S.P.; Vita-Marques, A.M.; Seleghim, M.H.R.; Bugni, T.S.; LaBarbera, D.V.; Sette, L.D.; Sponchiado, S.R.P.; Ireland, C.M.; Berlinck, R.G.S. New destruxins from the marine-derived fungus Beauveria felina, J. Antibiot. (2006), Manuscript submitted.

23. Ratnayake, A.S.; Bugni, T.S.; Feng, X.; Harper, M.K.; Skalicky, J.J.; Mohammed, K.A.; Andjelic, C.D.; Barrows, L.R.; Ireland, C.M. Theopapuamide: A cyclic depsipetide from a Papua New Guinea lithistid sponge Theonella swinhoei, J. Nat. Prod. (2006), Manuscript submitted.

Poster Presentations

• “Determination of Taxol and Taxane Titers in Endophytic Fungi using a Competitive Inhibition Enzyme Immunoassay (CIEIA)”, ACS national meeting, Anaheim, CA; April 1995.

• “Use of Immunoassay Techniques in the Determination of Taxoid Titers in Endophytic Fungi of Taxus brevifolia”, The 37th annual meeting of the American Society of Pharmacognosy, Santa Cruz, CA; July 1996.

• “Yanuthones: Novel Metabolites from a Marine Isolate of Aspergillus niger”, The 41st annual meeting of the American Society of Pharmacognosy, Seattle, WA; July 2000.

• “Dictyosphaeric acids A and B:  Novel Polyketides from an Undescribed Penicillium sp. Obtained from the Alga Dictyosphaeria versluyii”, 2004 Gordon Research Conference on Marine Natural Products, Ventura, CA.

Oral Presentations

•  “Use of Immunoassay Techniques in the Determination of Taxoid Titers in Endophytic Fungi of Taxus brevifolia”, ACS meeting-Montana section, Missoula, MT April, 1996.

• “Novel Compounds Isolated from an Endophytic Aspergillus sp.” ACS meeting-Montana section, Bozeman, MT, April, 1998.

• “Brocaenols A-C:  Novel Polyketides from a Marine-derived Penicillium brocae” The 43rd annual meeting of the American Society of Pharmacognosy, New Brunswick, NJ, July 2002.

• “Extraction and Prefractionation of Marine Invertebrate Samples and Plant Samples”, ICBG Network Meeting, Bethesda, MD, October, 2004.