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98. Edler, M.C.;
Fernandez, A.M.; Lassota, P.; Ireland, C.M.; Barrows, L.R. Inhibition of
Tubulin Polymerization by Vitilevuamide, a Bicyclic Marine Peptide, at a Site
Distinct from Colchicine, the Vinca Alkaloids and Dolastatin 10 Biochem.
Pharm. (2002) 63, 707-15.
99. Ersoz, T.;
Berkman, M.Z.; Tasdemir, D.; Calis, I.; Ireland, C.M. Iridoid and
Phenylethanoid Glycosides from Euphrasia pectinata Turk. J. Chem. (2002) 26, 179-88.
100. Verbitski, S.M.; Mayne,
C.L.; Davis, R.A.; Concepcion, G.P.; Ireland, C.M. Isolation, structure
determination, and biological activity of a novel alkaloid, perophoramidine,
from the Philippine ascidian Perophora namei. J. Org. Chem. (2002) 67, 7124-7126.
101. Davis, R.A.;
Aalbersberg, W.; Meo, S.; da Rocha, R.M.; Ireland, C.M. The isolation and synthesis
of polyandrocarpamines A and B. Two new 2-aminoimidazolone compounds from the
Fijian ascidian, Polyandrocarpa sp. Tetrahedron (2002) 58,
3263-3269.
102. Torres, Y.R.; Bugni,
T.S.; Berlinck, R.G.S.; Ireland, C.M.; Magalhaes, A.; Ferreira, A.G.; da Rocha,
R.M. Sebastianines A and B, novel biologically active pyridoacridine alkaloids
from the Brazilian ascidian Cystodytes dellechiajei J. Org.Chem. (2002) 67, 5429-5432.
103. Bugni, T.S.;
Concepcion, G.P.; Mangalindan, G.C.; Harper, M.K.; James, R.D.; Ireland, C.M.
p-Sulfooxyphenylpyruvic acid from the red macro alga Ceratodictyon
spongiosum and its sponge symbiont Haliclona
cymaeformis Phytochemistry (2002) 60, 361-363.
104. Kirmizibekmez, H.; Tasdemir, D.; Ersoz, T.;
Ireland, C.M. A new
pregnane glycoside and a furostanol glycoside from Digitalis cariensis
Pharmazie, (2002) 57, 716-720.
105. Calis, I.;
Kirmizibekmez, H.; Tasdemir, D.; Sticher, O.; Ireland, C.M. Sugar esters from Globularia
orientalis Z. Naturforsch. (2002) 57C, 591-596.
106. Ersoz, T; Tasdemir, D;
Calis, I; Ireland, C.M. Phenylethanoid glycosides from Scutellaria
galericulata Turk. J. Chem. (2002) 26, 465-471.
107. Ersoz, T.; Saracoglu,
I.; Tasdemir, D.; Kirmizibekmez, H.; Donmez, A.A.; Ireland, C.M.; Calis, I.
Neolignan glucosides from Phlomis chimerae Boiss
Z. Naturforsch, (2002) 57C, 221-225.
108. Calis, I.;
Kirmizibekmez, H.; Tasdemir, D.; Ireland, C.M. Iridoid glycosides from Globularia
davisiana. Chem. Pharm. Bull. (2002) 50, 678-680.
109. Calis, I.; Tasdemir,
D.; Ireland, C.M.; Sticher, O. Lucidin type anthraquinone glycosides from Putoria
calabrica Chem. Pharm. Bull (2002) 50, 701-702.
110. Edler, M.C.; Ireland,
C.M.; Barrows, L.R. Phage display derived peptide drug candidates against
tubulin: Comparison to traditional natural product discover Proceedings of the
American Association for Cancer Research Annual Meeting. (2002) 43, 1157.
111. Marshall, K.M.;
Matsumoto, S.S.; Ireland, C.M.; Holden, J.A.; Barrows, L.R. Neoamphimedine, a
unique topoisomerase II drug Proceedings of the American Association for
Cancer Research Annual Meeting (2002) 43,1156.
112. Tasdemir,
D.; Bugni, T.S.; Mangalindan, G.C.; Concepción, G.P.; Harper, M.K.; Ireland,
C.M. Cytotoxic Bromoindole Derivatives and Terpenes from the Philippine Marine
Sponge Smenospongia sp. Z.
Naturforsch, (2002) 57C, 914-922.
113. Tasdemir,
D.; Bugni, T.S.; Mangalindan, G.C.; Concepción, G.P.; Harper, M.K.; Ireland,
C.M. Bisaboline Type Sesquiterpenes from a Marine Didiscus Sponge Turk.
J. Chem. (2002) 26, 1-7.
114. Bugni,
T.S.; Bernan, V.S.; Greenstein, M.; Janso, J.E.; Maiese, W.M.; Mayne, C.L.;
Ireland, C.M. Brocaenols A-C:
Novel Polyketides from a Marine-Derived Penicillium brocae J. Org.Chem. (2003) 68, 2014-17.
115. Marshall, K.M.;
Matsumoto, S.S.; Holden, J.A.; Concepci`n,
G.P.; Tasdemir, D.; Ireland, C.M.; Barrows, L.R. The Anti-Neoplastic
and Novel Topoisomerase II Mediated Cytotoxicity of Neoamphimedine, a Marine
Pyridoacridine. Biochem. Pharm. (2003) 66, 447-58.
116. VanWagoner, R.M.;
Ireland, C.M. An Improved Solution Structure for y-Conotoxin PIIIE Biochemistry (2003) 42,
6347-52.
117. VanWagoner, R.M.;
Jacobson, R.B.; Olivera, B.M. Ireland, C.M. Characterization and
Three-Dimensional Structure Determination of y-Conotoxin PIIIF, a Novel Noncompetitive Antagonist of Nicotinic
Acetylcholine Receptors Biochemistry
(2003) 42, 6353-62.
118. Davis, R.A.; Sandoval,
I.T.; Concepcion,G.P.; Moreira da Rocha, R.; Ireland, C.M. Lissoclinotoxins E
and F, Novel Cytotoxic Alkaloids from a Philippine Didemnid Ascidian Tetrahedron (2003) 59,
2855 - 59.
119. James, R.D.; Jones,
D.A.; Aalbersberg W.; Ireland, C.M. Naamidine A Intensifies the
Phosphotransferase Activity of Extracellular Signal-regulated Kinases Causing
A-431 Cells to Arrest in G1
Mol. Cancer Ther. (2003) 2, 747-751.
120. Chevallier, C.;
Richardson, A.D.; Edler, M.C.; Hamel. E.; Harper, M.K.; Ireland
C.M. A new cytotoxic and tubulin-interactive milnamide derivative from a marine
sponge Cymbastela sp. Org Lett. (2003) 5,
3737-9.
121. Sandoval, I.T.; Davis,
R.A.; Bugni, T.S.; Concepcion, G.P.; Harper, M.K.; Ireland, C.M. Cytotoxic
Isoquinoline quinones from sponges of the genus Petrosia Nat. Prod. Res. (2003) 18, 89-93.
122. Davis, R.A.;
Christensen, L.V.; Richardson, A.D.; Moreira da Rocha, R.; Ireland, C.M. Rigidin
E, a New Pyrrolopyrimidine Alkaloid from a Papua New Guinea Tunicate, Eudistoma sp. Mar
Drugs (2003) 1, 27-33.
123. Pimentel, S.M.; Bojo,
Z.P.; Roberto, A.V.; Lazaro, J.E.; Mangalindan, G.C.; Florentino, L.M.;
Lim-Navarro, P.; Tasdemir, D.; Ireland, C.M.; Concepcion, G.P. Platelet Aggregation Inhibitors from
Philippine Marine Invertebrate Samples Screened in a New Microplate Assay
Mar. Biotechnol. (2003) 5, 395-400.
124. Ireland, C.M.;
Aalbersberg, W.; Andersen, R.J.; Ayral-Kaloustian, S.; Berlinck, R.; Bernan,
V.S.; Carter, G.T.; Churchill, A.C.L.; Clardy, J.; Concepcion, G.P.; De Silva,
E.D.; Discafani, C.; Fojo, T.; Frost, P.; Gibson, D.; Greenberger, L.M.;
Greenstein, M.; Harper, M.K.; Mallon, R. ; Loganzo, F.; Nunes, M.; Poruchynsky,
M.S.; Zask, A. Anticancer Agents
from Unique Natural Products Sources Pharm. Bio. (2003) 41, Supplement,
15-38.
125. Gazar, H.A.; Tasdemir,
D.; Ireland, C.M.; Calis, I. Irinoids and triterpene saponins from Verbascum
wiedemannianum. Biochem. Syst.
Ecol. (2003) 31, 433-36.
126. Verbitski, S.M.;
Mullally, J.E.; Fitzpatrick, F.A.; Ireland, C.M. Punaglandins, Chlorinated
Prostaglandins, Function as Potent Michael Receptors to Inhibit Ubiquitin
Isopeptidase Activity J. Med. Chem.
(2004) 47, 2062-70.
127. Davis, R.A.;
Mangalindan, G.C.; Bojo, Z.P.; Antemano, R.R.; Rodriguez, N.O.; Concepcion,
G.P.; Samson, S.C.; de Guzman, D.; Cruz, L.J.; Tasdemir, D.; Harper, M.K.;
Feng, X.; Carter, G.T.; Ireland, C.M.
Microcionamides A and B, Bioactive Peptides from the Philippine Sponge Clathria
(Thalysias) abietina J. Org.Chem. (2004) 69, 4170-76.
128. Bugni, T.S.; Janso,
J.E.; Williamson, R.T.; Feng, X. Bernan, V.S.; Greenstein, M.; Carter, G.T.;
Maiese, W.M.; Ireland, C.M. Dictyosphaeric acids A and B: Novel metabolites from an undescribed Penicillium sp. obtained from the alga Dictyosphaeria
versluyii J.
Nat. Prod. (2004) 67, 1396-99.
129. Richardson, A.D.;
Ireland, C.M. A profile of the in vitro antitumor activity of lissoclinolide Tox.
App. Pharm. (2004) 195, 55-61.
130. Bugni, T.S.; Singh, M.P.; Chen, L.; Arias, D.A.; Harper, M.K.; Greenstein,
M.; Maiese,M.M.; Concepcion, G.P.; Mangalindan, G.C.; Ireland, C.M. Kalihinols
from two Acanthella cavernosa sponges:
inhibitors of bacterial folate biosynthesis Tetrahedron (2004) 60,
6981-88.
131. Andersen, R.J.;
Ireland, C.M.; Molinski, T.F.; Bewley, C.A. Research Achievement Award-D. John Faulkner J. Nat. Prod. (2004) 67,
1239-51.
132. Jette, C.; Peterson,
P.W.; Sandoval, I.T.; Manos, E.J.; Hadley, E.; Ireland, C.M.; Jones, D.A. The
tumor suppressor adenomatous polyposis coli and caudal related homeodomain
protein regulate expression of retinol dehydrogenase L. J. Biol. Chem. (2004) 279, 34397-405.
133. Bobzin, S.C.;
Cardellina, J.H. 2nd; Gerwick, W.H.; Okuda, R.K.; Harper, M.K.; Ireland, C.M.
Special issue in honor of D. John Faulkner and Paul J. Scheuer J. Nat. Prod. (2004) 67, 1201-3.
134. Ratnayake, A.S; Davis,
R.A.; Harper, M.K.; Veltri, C.A.; Andjelic, C.D.; Barrows, L.R.; Ireland, C.M.
Aurantosides G, H, and I: three new tetramic acid glycosides from a Papua New
Guinea Theonella swinhoei. J.
Nat. Prod. (2005) 68, 104-7.
135. Richardson, A.D.,
Aalbersberg, W.; Ireland, C.M. The patellazoles inhibit protein synthesis at
nanomolar concentrations in human colon tumor cells. Anti-Cancer Drugs (2005) 16,
533-41.
136. Janso, J.E.; Bernan,
V.S.; Greenstein, M.; Bugni, T.S.; Ireland, C.M. Penicillium dravuni, a new marine-derived species from an alga in Fiji. Mycologia (2005) 97,
444-53.
137. Dijoux, M.G.; Schnabel,
P.C.; Hallock, Y.F.; Boswell, J.L.; Johnson, T.R.; Wilson, J.A.; Ireland, C.M.;
van Soest, R.; Boyd, M.R.; Barrows, L.R.; Cardellina, J.H. 2nd Antitumor activity and distribution of
pyrroloiminoquinones in the sponge genus Zyzzya. Bioorg. Med. Chem.
(2005) 13, 6035-44.
138. Chevallier, C.; Bugni,
T.S.; Feng, X.; Harper, M.K.; Orendt, A.M.; Ireland, C.M. Tedanolide C: a
potent new 18-membered ring cytotoxic macrolide isolated from the Papua New
Guinea marine sponge Ircinia sp. J. Org.Chem. (2006) 71, 2510-13.
140. Alexander, M.D;
Burkart, M.D; Leonard, M.S; Portonovo, P.; Liang, B.; Ding, X.; Joullié, M.M.;
Gulledge, B.M.; Aggen, J.B.; Chamberlin, A.R.; Sandler, J.; Fenical, W.;J
Cui,J.; Gharpure, S.J.; Polosukhin, A.; Zhang, H.R.; Evans, P.A.; Richardson,
A.D.; Harper, M.K.; Ireland, C.M.; Vong, B.G.; Brady, T.P.; Theodorakis, E.A.;
La Clair, J.J. A unified strategy for converting natural products into
fluorescent probes ChemBioChem, (2006) 7, 409-16.
141. Ratnayake, A.S.; Bugni,
T.S.; Veltri, C.A.; Skalicky, J.J.; Ireland, C.M. Chemical transformation of
prostaglandin-A2: a novel series of C-10 halogenated, C-12 hydroxylated
prostaglandin-A2 analogues Org Lett.
(2006) 8, 2171-4.
142. Shelton, D.N.;
Sandoval, I.T.; Eisinger. A.; Chidester, S.; Ratnayake, A.; Ireland, C.M.;
Jones, D.A. Up-regulation of CYP26A1 in adenomatous polyposis coli-deficient
vertebrates via a WNT-dependent mechanism: implications for intestinal cell
differentiation and colon tumor development. Cancer Res. (2006) 66, 7571-7.
Books
and Monographs
1. Ireland,
C. "The Chemistry of Some
Opisthobranch Molluscs."
Ph.D. thesis, University of California, 1977, pp. 137.
2. Faulkner,
D.J. and Ireland, C. "The
Chemistry of Some Opisthobranch Molluscs." In D.J. Faulkner and W.H. Fenical (eds.), Marine Natural
Products Chemistry. New York: Plenum Press, 1977, pp. 23.
3. Ireland,
C. M.; Molinski, T. F.; Roll, D. M.; Zabriskie, T. M.; McKee, T. C.; Swersey,
J. C. and Foster, M. P.
"Natural Product Peptides from Marine Organisms." In P. J. Scheuer (ed.), Bioorganic
Marine Chemistry, Vol. 3. New York: Springer-Verlag, 1989, pp. 46.
4. Ireland,
C.M. “Marine Natural Products in the 21st Century: The Importance of
Maintaining Bio-Diversity and Promoting Biotechnology for Developing
Pharmaceuticals from the Sea” Environment, Science and Technology: The
Challange of the 21st Century
(Proceeding of The Second Princess Chulabhorn Science Congress, Vol. 1)
Bangkok, Chulabhorn Research Institute, 1992, pp.539-50.
5. Ireland,
C.M.; Copp, B.R.; Foster, M.P.; McDonald, L.A.; Radisky, D.C.; Swersey,
J.C. "Biomedical Potential of
Marine Natural Products" in D.H. Attaway and O.R. Zaborsky (eds.), Marine
Biotechnology, Vol. 1. New York: Plenum
Press, 1993, pp. 43.
6. Ireland,
C.M.; Copp, B.R.; Foster, M.P.; McDonald, L.A.; Radisky, D.C.; Swersey,
J.C. "Bioactive Compounds
from the Sea" in R.E. Martin, E.P. Carter, L. M. Davis and G. J. Flick Jr.
(eds.), Marine and Freshwater Products Handbook, Lancaster: Technomic Publishing, 2000, pp. 641-62.
7. Harper,
M.K.; Bugni, T.S.; Copp, B.R.; James, R.D.; Lindsay, B.S.; Richardson, A.D.;
Schnabel, P.C.; Tasdemir, D.; VanWagoner, R.M.; Verbitski, S.M.; Ireland, C.M.
“Introduction to the Chemical Ecology of Marine Natural Products” in J.B.
McClintock and B.J. Baker (eds.), Marine Chemical Ecology, Boca Raton: CRC Press, 2001, pp. 3-69.
8. Bugni,
T.S.; Ireland, C.M. “Marine-Derived Fungi: A Chemically and Biologically Diverse Group of
Microorganisms” in Natural Products Reports (2004) 21, 143-163.
Patents
1. Ireland,
C.M. “Novel Patellazoles” (1994)
US Patent #383,739
2. Ireland,
C.M.; Radisky, D.C.; Barrows, L.R.; Kramer, R.A. Antineoplastic and Antibacterial Pyrrolo[4,3,2-DE]
quinolin-8(1H)-ones (1995) US
Patent #5,414,001.
3. McDonald,
L.A.; Maiese, W.W.; Ireland, C.M.
Namenamicin, a New Enediyne Antitumor Antibiotic from the Marine
Ascidian Polysyncraton lithostrotum (October
20, 1995) Provisional US Patent.
Full patent application filed October 1996.
4. Fernandez,
A., Ireland, C.M. Vitilevuamide, A
Cyclic Peptide Antitumor Agent. Full patent application filed September 25,
1996.
5. Naamidine
A Extracted from Sea Sponges and Methods for its use as an Anti-Tumor Agent
(November 12, 1996) US patent #5574057.
