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 Thanks for finding us online! We have a new look, updated information, and many exciting developments detailed in our new Pharmaceutics website!
Upcoming Events, February 8 thru february 12 Seminars February 8, 2010 College of Pharmacy Special Guest Lecturer  Kim Janda, Ph.D. Click here for details. February 10, 2010 Bioengineering Seminar Series  You Han Bae, Ph.D. February 11, 2010 Priscilla M. Mayden Lecture  Joyce Mitchell, Ph.D., FACMI, FACMG http://library.med.utah.edu/or/pmayden/pmayden.php
 Michael Raghunath, Ph.D. http://www.bioen.utah.edu/seminars/presentation.php?id=263 |
 "Toxicity of Silver Nanoparticles"
Darin Y. Furgeson, PhD (Assistant Professor of Pharmaceutics and Pharmaceutical Chemistry) was recently featured for his silver nanoparticle toxicity work in Scientific American. This nanotoxicology research is currently focused on establishing a correlative and predictive nanotoxicity model with zebrafish. Zebrafish are an established and validated model with similar organs to humans (including the liver, kidney, spleen, and blood brain barrier); possess 80-85% homology to the human genome; and provide an integrated multi-cellular system, vastly superior to the current paradigm of in vitro cell culture assays. Furgeson studies the physical chemistry of nanomaterials, such as particle size, shape, and surface charge, and associated nanotoxicity-induced perturbations in gene expression, signal paths, and cell mechanisms. This work is part of a larger research project in Furgeson's lab broadly stated as Zebrafish Development as a Model for Pediatric Environmental Health. This multi-disciplinary project is in collaboration with Joseph Yost, PhD (Professor of Cell Biology and Neurobiology), David Grainger, PhD (Professor and Chair of Pharmaceutics and Pharmaceutical Chemistry), and Ed Clark, MD (Professor and Chair of Pediatrics, CMO of PCMC). Read story » {Title}
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ADMISSIONS
Research
 The Department of Pharmaceutics and Pharmaceutical Chemistry occupies approximately 24,000 square feet of space in the College of Pharmacy and two nearby locations, all proximal to the Health Sciences Center and Health Sciences Library. Read story » Publications
To view all publications, click here.
V. Nadithe, Y.H. Bae, "Low p50 hemoglobin conjugated with antioxidant enzymes via poly (ethylene glycol) cross-linker (Hb-SOD-CAT) for protection of isolated cells in hypoxia". Biomacromol (submitted)
R. Lavery, K. Zakrzewska, D.L. Beveridge, T.C. Bishop, D.A. Case, T.E. Cheatham, III, S. Dixit, B. Jayaram, F. Lankas, C. Laughton, J.H. Maddocks, A. Michon, R. Osman, M. Orozco, A. Perez, T. Singh, N. Spackova, and J. Sponer. "A systematic molecular dynamics study of nearest-neighbor effects on base pair and base pair step conformations and fluctuations in B-DNA". Nuc. Acids Res. (2009) [In press].
O Bar-Ilan, RA Albrecht, VE Fako, and DY Furgeson."Toxicity assessments of multi-sized gold and silver nanoparticles in zebrafish embryos". Small (2009) 5(16):1897-1910.
K. Kitchens, and H. Ghandehari, "PAMAM Dendrimers as Nanoscale Oral Drug Delivery Systems", in Nanotechnology in Drug Delivery, M.M. deVilliers, P. Aramwit, and G.S. Kwon (Eds), Springer Science, New York, NY, pp. 423-459 (2009)
C. Jones and D.W. Grainger, "In vitro assays and experimental models of nanomaterial toxicity", Adv. Drug Del. Rev., 61 438-456;
Christensen, D. A. and J. N. Herron, "Optical System Design for Biosensors Based on CCD Detection. In: Biosensors and Protocols, Volume 1: Optical-Based Detectors (Rasooly, A. and Herold, K. E., eds.). Series": Methods in Molecular Biology, Vol 503. Humana Press, Totowa, NJ., pp. 239-258 (2009).
Steimer JL, Dahl S, De Alwis D, Gundert-Remy U, Karlsson M, Martinkova J, Aarons L, Ahr HJ, Clairambault J, Freyer G, Friberg L, Kern S, Ludwig WD, De Nicolao G, Rocchetti M, Troconiz I: "Modelling the genesis and treatment of cancer: the potential role of physiologically-based pharmacodynamics". Eur J Cancer, 2009 in press
K. Dušek, M. Dušková-Smrčková, J. Yang, J. Kopeček, "Coiled-Coil Hydrogels. Effect of Grafted Copolymer Composition and Cyclization on Gelation", Macromolecules 42, 2265-2274 (2009) Cadwallader, A., Lim, C.S., and Rollins, D.E., "Activity of Abused Steroids in a Cell Based Biological Assay", submitted, Molecular Pharmaceutics More publications, click here. |
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