Pavla Kopeckova

UNIVERSITY OF UTAH

DEPARTMENT OF PHARMACEUTICS AND PHARMACEUTICAL CHEMISTRY

DEPARTMENT OF BIOENGINEERING

20 S 2030 E Rm 205
Salt Lake City, Utah 84112
Phone: (801) 581-7349
FAX: (801) 581-7848

EDUCATION

M.S. Organic Chemistry, Institute of Chemical Technology, Prague, Czechoslovakia, 1968

Ph.D. Macromolecular Chemistry, Institute of Macromolecular Chemistry, Czechoslovak Academy of Sciences, Prague, 1981

APPOINTMENTS

• Research Professor, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, since 1998.
• Research Associate Professor, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 1989-1997.
• Research Associate Professor, Department of Bioengineering, University of Utah, since 1989.
• Visiting Associate Professor, Department of Pharmaceutics and Pharmaceutical Chemistry, and of Bioengineering, University of Utah, October 1988-May 1989.
• Visiting Associate Professor, Department of Bioengineering, University of Utah, May-December 1987.
• Senior Research Scientific Officer, Institute of Macromolecular Chemistry, Czechoslovak Academy of Sciences, Prague, 1986-1988
• Exchange Scientist, All-Union Cardiological Center, Academy of Medical Sciences, Moscow, USSR, June-July 1985.
• Exchange Scientist, Department of Biological Sciences, University of Keele, United Kingdom, October-November 1982 and October 1984.
• Research Scientific Officer, Institute of Macromolecular Chemistry, Czechoslovak Academy of Sciences, Prague, 1981-1986.
• Ph.D. Student, Institute of Macromolecular Chemistry, Czechoslovak Academy of Sciences, Prague, 1978-1981.
• Research Assistant, Institute of Macromolecular Chemistry, Czechoslovak Academy of Sciences, Prague, 1968-1978.

SOCIETIES

• American Chemical Society
• Controlled Release Society
• American Association of Pharmaceutical Scientists

RESEARCH INTERESTS

• Bioorganic Polymer Chemistry
• Biodegradability of Polymers
• Bioconjugate Chemistry
• Drug Delivery Systems

PAVLA'S HOBBIES

• Skiing
• Hiking
• Photography
• Gardening
  

Recent Articles
(year 2008-2009)

(Revised February, 2009)

J. Liu, P. Kopeckova, P. Buhler, P. Wolf, H. Pan, H. Bauer, U. Elsasser-Beile, J. Kopecek Biorecognition and Subcellular Trafficking of HPMA Copolymer-Anti-PMSA Antibody Conjugates by Prostate Cancer Cell
Molecular Pharmaceutics, submitted

J. Callahan, P. Kopeckova, J. Kopecek
The Intracellular Trafficking and Subcellular Distribution of a Large Array of HPMA Copolymers
Biomacromolecules, submitted

S. Gao, Y. Sun, P. Kopeckova, C.M. Peterson, J. Kopecek
Antitumor Efficacy of Colon-Specific HPMA Copolymer 9-Aminocamptothecin Conjugate in Mice Bearing Human Colon Carcinoma Xenografts
J. Controlled Release submitted

E. Segal, H. Pan, P. Ofek, T. Ugadawa, P. Kopeckova, J. Kopecek, R. Satchi-Fainaro
Targeting-Angiogenesis-Dependent Calcified Neoplasms Using Combined Polymer Therapeutics
PLoS ONE, in press

R.N. Johnson, P. Kopeckova, J. Kopecek
Synthesis and Evaluation of Multivalent Branched HPMA Copolymer-Fab' Conjgates Targeted to the B-Cell Antigen
Bioconjugate Chem., 20, 129-137 (2009)

W. Yuan, J. Yang, P. Kopeckova, J. Kopecek
Smart Hydrogels Containing Adenylate Kinase: Translating Substrate Recognition into Macroscopic Motion
J. Am. Chem. Soc., 130, 15760-15761 (2008)

S.C. Miller, H. Pan, D. Wang, B.M. Bowman, P. Kopeckova, J. Kopecek
Feasibility of Using a Bone-Targeted, Macromolecular Delivery System Coupled with Prostaglandin E₁ to Promote Bone Formation in Aged, Estrogen-Deficient Rats
Pharmaceutical Res., 25, 2889-2895 (2008)

J. Hongrapipat, P. Kopeckova, J. Liu, S. Prakongpan, J. Kopecek
Combination Chemotherapy and Photodynamic Therapy with Fab' Fragment Targeted HPMA Copolymer Conjugates in Human Ovarian Carcinoma Cells
Molecular Pharmaceutics, 5, 696-709 (2008)

V. Cuchelkar, P. Kopeckova, J. Kopecek
Novel HPMA Copolymer-Bound Constructs for Combined Tumor and Mitochondrial Targeting
Molecular Pharmaceutics, 5, 776-786 (2008)

H. Pan, M. Sima, P. Kopeckova, K. Wu, S. Gao, J. Liu, D. Wang, S.C. Miller, J. Kopecek
Biodistribution and Pharmacokinetic Studies of Bone-Targeting N-(2-Hydroxypropyl)methacrylamide Copolymer-Alendronate Conjugates
Molecular Pharmaceutics, 5, 548-558 (2008)

H. Pan, J. Liu, Y. Dong, M. Sima, P. Kopeckova, M.L. Brandi, J. Kopecek
Release of Prostaglandin E₁ from N-(2-Hydroxypropyl)methacrylamide Copolymer Conjugates by Bone Cells
Macromol. Biosci., 8, 599-605 (2008)

V. Cuchelkar, P. Kopeckova, J. Kopecek
Synthesis and Biological Evaluation of Disulfide-Linked HPMA Copolymer- Mesochlorin e₆ Conjugates
Macromol. Biosci., 8, 375-383 (2008)

K. Wu, J. Yang, C. Konak, P. Kopeckova, J. Kopecek
Novel Synthesis of HPMA Copolymers Containing Peptide Grafts and their Self-Assembly into Hybrid Hydrogels
Macromol. Chem. Phys., 209, 467-475 (2008)

S.-Q. Gao, Y. Sun, P. Kopeckova, C.M. Peterson, J. Kopecek
Pharmacokinetic Modeling of Absorption Behavior of 9-Aminocamptothecin (9-AC) Released from Colon-specific HPMA Copolymer-9-AC Conjugate in Rats
Pharmaceutical Res., 25, 218-226 (2008)

J. Hongrapipat, P. Kopeckova, S. Prakongpan, J. Kopecek
Enhanced Antitumor Activity of Combinations of Free and HPMA Copolymer-bound Drugs
Int. J. Pharmaceutics, 351, 259-270 (2008)

Revised February, 2009

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