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Department of Pharmaceutics & Pharmaceutical Chemistry
College of Pharmacy 301 Skaggs Hall 30 South 2000 East Salt Lake City, UT 84112 phone: (801) 581-7831 fax: (801) 581-3674 |
Newsletter
Department of Pharmaceutics and Pharmaceutical Chemistry December, 2000 Volume 2 Contents
the Chair Welcome to the second issue of our Newsletter! In the last twelve months the renewal of the Department successfully continued. In October, Dr. Bruce Yu joined our faculty as an Assistant Professor. On behalf of our faculty, students, and staff I would like to welcome Bruce in our Department and wish him success in his work. We look forward to working with you! Within the last fourteen months three new young Assistant Professors; Carol Lim, Steve Kern, and Bruce Yu joined our faculty. This bodes very well for the future of our Department. The scholarship, dedication and modern research areas of our faculty create an environment where graduate students develop their talents to the fullest and prepare for future leadership roles in the field. We have started the evaluation of graduate curriculum with the aim to improve it to match the challenges of the new millennium. Our plan is to finish the process by the end of this academic year and to implement the new curriculum in the 2002-2003 academic year. Please let us know of your experience in the life "out there". Your comments on the value and usefulness of the education you received while in Utah will be very helpful. The generosity of our donors contributes considerably to the fulfillment of one of our major goals - to continue to attract outstanding students. I am pleased to announce several new fellowships. Enzon, Inc. supports three ENZON fellowships and Novartis supports one NOVARTIS Fellowship for first year graduate students. Generous donations towards our graduate program were obtained from Abbott Laboratories Fund and Pfizer. Continuing support comes from the Dr. Dinesh and Kalpana Patel Fellowship, Higuchi Fellowship, and the Dr. Roy Kuramoto Fellowship. However, additional student support is a prerequisite for continuing success. I would like to thank all individuals who made donations toward our graduate program and to those who contributed to the Jeff Fox Memorial Fund. Your generosity is appreciated! Please continue to support us. All of your contributions help our graduate program. At present there are 34 graduate students (33 Ph.D., 1 M.S.) in the Department. In addition, 8 graduate students from other Departments (Bioengineering, Chemical Engineering) work with our faculty. The graduate students are supported by the Fellowships mentioned above and from peer reviewed grants awarded to our faculty. We shall be happy to mail a Student Directory upon request. Dr. Bradley Anderson accepted the position of Chair of the Division of Pharmaceutical Sciences at the University of Kentucky in Lexington. Best wishes for continuing success! A search committee will select a candidate to fill his position. We hope that the new faculty will join us by next July. The first issue of the Newsletter contributed to the communication with alumni and friends. Please continue to contact us with suggestions, memories, and messages throughout the year at Jindrich.Kopecek@m.cc.utah.edu. Your help and advice are needed in this time of transformation. Please visit the Department home page at www.pharmaceutics.utah.edu. The home page contains news from the Department, information on our faculty research, the Newsletter (Nos. 1 & 2), and other important information. Please visit the Department if you are in the area. We shall be happy to arrange your visit of our faculty and students if you contact us in advance. Finally, I would like to thank Sue Sawsak, the Department's Office Coordinator for the design and production of this Newsletter. The faculty, students and staff wish all alumni and friends a Wonderful Holiday Season and a Happy and Successful New Year. Jindrich (Henry) Kopecek Professor and Chair
FACULTY UPDATES
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Bruce Yu, a new faculty member, joined our department in October 2000 as a tenure-track Assistant Professor. Dr. Yu received his B.S. in Biochemistry from Peking University in 1987. In 1990, he enrolled at the then newly established Inter-departmental program in Macro-molecular Biophysics at the Johns-Hopkins University and obtained his Ph.D. in 1996. Bruce's postdoctoral work was carried out at the University of Alberta, in the field of Synthetic Peptide Chemistry, from 1997 to 2000.
Bruce's research area is protein engineering. In particular, the focus is on the different forces that determine protein structural study and specificity. Dr. Yu invented the residue shuffling approach to make peptide mutants, which has shown great potential in the study of protein energetics. He employs both experimental and theoretical approaches in his research. In the future, Bruce would like to continue to work on the fundamental questions regarding protein structure and using the knowledge gained to the design of new protein/peptide therapeutics.
STUDENT ACTIVITIES
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This past year the students in the Department have played an active role in raising awareness and advertising the department to potential graduate students. In addition to their activities outside the department, the SAC has organized socials and an AAPS Student Chapter to increase unity and participation in the department. A few of the most notable activities over the past year include: The election of new student leadership in the Student Advisory Committee (SAC). In December, Monica Tijerina was elected and took the place of Jonathan Benns, and in May, Mark Liddell and Ram Goteti were elected to replace Kevin Warner and Ryan Hansen.
Early in the year Anil Chhettry was instrumental in establishing the Dr. Jeff Fox Memorial Award. The first recipient was Anthony Barry. This award was established to recognize a student who exemplifies academics, research, and service to the department and/or college. The award recipient is nominated by their peers and name engraved on a plaque that hangs next to the Enz Award plaque on the third floor of Skaggs Hall (across from the Department Office). ALUMNI NEWS (top) ALUMNI AND FRIENDS BREAKFAST: A GREAT SUCCESS (top)  Meeting old friends and making new ones at the Annual Alumni Breakfast, 2000 AAPS Meeting, Indianapolis
At the recent AAPS meeting, the breakfast of the alumni and friends of the Department of Pharmaceutics and Pharmaceutical Chemistry took place at the Westin Hotel on October 31, 2000. More than 50 people were present at the breakfast. It was great seeing all of you and discussing your experiences from your professional and personal lives. We hope that you got acquainted with the present state and future plans of the Department. Please keep in touch during the year. The department faculty, students, and staff would like to know what you are doing. Thank you all for coming. We hope to see you again next year in Denver!
ALUMNI HIGHLIGHT
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Drs. Lars Hovgaard and Helle Brondsted graduated in 1987 from the Royal Danish School of Pharmacy in Copenhagen, Denmark with their Masters degree in pharmacy. As husband and wife they entered the graduate program in the Department of Pharmaceutics and Pharmaceutical Chemistry at the University of Utah in the fall of 1987. Helle Brondsted entered a very fruitful research project in the area of azo-crosslinked polymers for colon-specific drug delivery under the supervision of Professor Henry Kopecek. Lars Hovgaard focused on the mucosal transport of peptide and proteins across rat intestines They were offered individual faculty positions in the Department of Pharmaceutics at the Royal Danish School of Pharmacy, where they quickly established strong common research in the areas of crosslinked dextran polymers for colon-specific drug delivery. This resulted in a world wide patent application and the usage of Caco-2 cells for pharmaceutical screening. This resulted in a world wide patent application and the usage of Caco-2 cells for pharmaceutical screening. After obtaining tenure, Helle continued working with colon-specific drug delivery while starting a new research area of peptide formulation. In 1998 Helle moved to the Department of Analytical and Pharmaceutical Chemistry and has started new research in the area of bypass of first pass metabolism by chemical modification of drugs. Lars initiated the area of pharmaceutical formulation of DNA drugs in 1997, although not letting go of the Caco-2 cells. At this point he has established a group of 4 Ph.D. students focusing on formulations of oligonucleotides, plasmid DNA and peptide vaccines. He carries a young investigator award from the Danish Research Academy as well as significant private funding for equipment. Over the years they have both published some 30-35 original manuscripts together and apart. Helle Brondsted has supervised 2 Ph.D. students, numerous M.S. students and served on referee boards as well as scientific advisory boards. Lars Hovgaard has supervised 10 Ph.D. students, more than 35 M.S. students and scholars. He serves a referee on most pharmaceutical journals. At present, he is the head of a group consisting of 3 faculty members, 4 technicians, 1 post-doc and 8 Ph.D. students. Recently his work on formulation of genetic drugs has inspired the launch of a contract formulation start-up company in Denmark.
Drs. Brondsted and Hovgaard believe, "There is no doubt that the strong training and the scientific network that both acquired at the University of Utah has been one of the determining factors to their success". DONOR HIGHLIGHTS (top) Diamond Donors - Fellowships $10,000 and up (top) ENZON Fellowship (top) The department is pleased to announce the establishment of three ENZON Fellowships in Pharmaceutics and Pharmaceutical Chemistry. The fellowships will assist graduate students in their first year of the Department's doctoral program. Dr. Jeffrey McGuire, Vice President of Research and Development and Chief Scientific Officer at ENZON, Inc. was very instrumental in obtaining this three-year commitment. We would like to expressly thank Dr. McGuire for all of his efforts. ENZON, Inc. is a biopharmaceutical company developing and commercializing advanced therapeutics for life-threatening diseases through the application of its proprietary drug delivery and targeting technologies, PEG Modification, Pro Drug/transport technology and Single-Chain Antigen-Binding (SCAâ) protein technology. ENZON's research activities are focused primarily in the area of oncology, with applying its technologies to enhance the performance of compounds with known therapeutic efficacy. Headquartered in Piscataway, New Jersey, ENZON, Inc. has formed strategic alliances for its proprietary technologies and products. ENZON, Inc. has two FDA approved products, as well as several products in various stages of clinical development.
The generosity of ENZON, Inc. will have a positive impact on the strength of our graduate program. We are grateful for their support.
Fellowships are integral for the success of our program. The department is very grateful for the generous donation and hopes that Novartis will continue to support our program.
We would like to once again thank Dr. William and Sets Higuchi for their continuous support of our graduate students by way of the Higuchi Fellowship. One fellowship is awarded each academic year to an outstanding graduate student.
The department would like to thank Dr. and Mrs. Patel for their continued support of our program. The Dinesh and Kalpana Fellowships assist graduate students from the Patel's native country of India during their first year of our doctoral program. One fellowship is awarded annually to a top candidate.
The department is grateful for the Kuramoto Fellowship, which has been a continuing source of support for Pharmaceutics and Pharmaceutical Chemistry graduate students. One fellowship is awarded annually to a promising first year graduate student. Acknowledgements
(top) The department would like to recognize Dr. Timothy A. Hagen and Dr. Gene Fiese of Pfizer and Dr. Peter Tarcha of Abbott Laboratories. They were instrumental in obtaining funds from their organizations. The department would also like to thank all of the individuals and companies that made donations to our funds: Graduate Student Fund (GSF) and the Jeffrey L. Fox Memorial Fund (JFMF) throughout the year 2000. The following is a list of contributors (non-fellowships):
As Dr. Kopecek indicated in his message, we are very appreciative of all of our donors. Many companies will match employee contributions, please check with your employer to see if this benefit is available. We look forward to adding your name to our donor list. Please send your contribution to: University of Utah Department of Pharmaceutics and Pharmaceutical Chemistry 30 South 2000 East, Rm. 301 Salt Lake City, Utah 84112
With your gift please indicate the fund you wish to contribute or if you would like to establish a new fellowship, please contact Dr. Kopecek at 801/581-4532 or Jindrich.Kopecek@m.cc.utah.edu
AWARDS AND HONORS 1999-2000
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Dr. Joseph Andrade was awarded an honorary doctorate (Dr.h.c.) degree from the University of Uppsala, Sweden. Dr. James Herron was appointed Director of the University's Center for Biopolymers at Interfaces this past August. Dr. William Higuchi was awarded the Millennial Pharmaceutical Scientist Award (2000). Dr. Sung Wan Kim was awarded the title of Distinguished Professor. Dr. Henry Kopecek received the Millennial Pharmaceutical Scientist Award (2000) and was elected Vice-Chair (2002) and Chair (2004) of Gordon Research Conference on Drug Carriers in Medicine and Biology.
Dr. Carol Lim received the American Association of Colleges of Pharmacy (AACP) New Investigators Program for Pharmacy Faculty Award (2000). Keith Jensen - Walter F. Enz Award from Pharmacia-Upjohn Corporation Kevin Warner - PhRMA Foundation Predoctoral Fellowship Anthony Barry - Jeffrey L. Fox Memorial Award Aijun Tang - Graduate Research Fellowship from the University of Utah Kosalaram Goteti - Dinesh and Kalpana Patel Fellowship Charu Kanwal - Kuramoto Fellowship Matthew Fidler - Higuchi Fellowship
Kevin Warner - Elected Post Graduate Officer for APhA
SUMMER UNDERGRADUATE PROGRAM
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Nathan Ackroyd (Kopecek Lab), "Polymerizable Colied-Coil Peptides Prepared by Chemical Derivatization of Terminal His-Tags" Angie Adams (Lim Lab), "Differential Localization of the Human PR: is a NES Involved?" Erica Gillies (Kern Lab), "A Comparison of Propofol in Diprivan and Propofol in Captisol: Analyzing the Bioequivalence through Pharmacokinetic Modeling" Todd Gruber(Herron Lab), "Rejection Ratio Optimization of 21 Base Pair Singe Mismatch Oligonucleotides" Richard Hymas (Higuchi Lab), "Problems with Constant Current Iontophoresis of Human Epidermal Membrane" Kongnara Papangkorn (Herron Lab), "Formulation of HEL-FAB' Construct as a Novel Antiidiotype Vaccine" The department wishes to acknowledge Dr. Higuchi for his continued generosity in funding this program. An additional thank you goes to the entire Pharmaceutics and Pharmaceutical Chemistry faculty for their added funding.
INTERNATIONAL SYMPOSIUM ON DRUG DELIERY SYSTEMS
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The 10th International Symposium on Recent Advances in Drug Delivery Systems, co-chaired by S.W. Kim and J. Kopecek will take place on February 19-22, 2001 at the Salt Lake City Marriott. The Symposium will be held in honor of James M. Anderson's 60th birthday. The topics cover protein formulation and delivery, biological and physicochemical barriers for controlled drug delivery, gene delivery, novel drug delivery systems, clinical aspects of drug delivery systems, and future prospects of biomaterials. Visit the Symposium web site at: www.pharmaceutics.utah.edu/cccd
ACTIVE NIH/NSF GRANTS
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NIH Grant HL32132; Multi-analyte Waveguide Immunosensing; J.N. Herron, PI. NIH Grant DE06569; Quantitation of Enamel Demineralization Mechanisms, W.I. Higuchi, PI. NIH Grant GM/HL56098; New Biodegradable Polymers for Protein Drug Delivery; S.W. Kim, PI. NIH Grant DK56884; Bioactive Polymers for Effective Islet Drug Delivery System; S.W. Kim, Co- PI. NIH Grant CA88047; Targeting to Lymphocytes Mediated by Synthetic Epitopes; J. Kopecek, PI. NIH Grant CA51578; A Polymeric Drug Delivery System for Cancer Therapy; J. Kopecek, PI. NIH Grant GM50839; Degradable Hydrogels for Oral Delivery of Calcitonin; J. Kopecek, PI. NIH Grant DK39544; Bioadhesive Polymers for Treatment of Colon Disease; J. Kopecek, PI.
NSF Grant BES-9807287; Hybrid Hydrogels with Swelling Transitions Modulated by Protein Domains; J. Kopecek, Co-PI.
PAPERS PUBLISHED IN 2000
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Joseph Andrade (top) "Active Microneedles with Integrated Functionality", J. Brazzle, D. Barholomeusz, R. Davies, J. Andrade, R. VanWagenen, and A.B. Frazier, Solid State Sensors and Actuators Workshop, June 4-8, 2000.
"BCCP-Firefly Luciferase Immobilized on Avidin-coated Agarose Beads", J-Y. Eu and J. Andrade, Luminescence, in press. James Herron
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"Planar Waveguide Biosensor for Nucleic Acid Hybridization Reactions", J. N. Herron, S. zum Brunnen, J-X. Wang, X-L. Gao, H-K. Wang, A.H. Terry, and D.A. Christensen, SPIE Vol. 3919 (In-Vitro Diagnostics Instrumentation), 177-184 (2000). "Evanescent Planar Waveguide Detection of Biological Warfare Simulants", D.M. Sipe, K.P. Schoonmaker, J.N. Herron, and M.J. Mostert, SPIE Vol. 3913 (In-Vitro Diagnostics Instrumentation), 215-222 (2000). "Force Probe Measurements of Antibody-Antigen Interactions", D.E. Leckband, T.L. Kuhl, H-K. Wang, J.N. Herron, W. Muller, and H. Ringsdorf, Immunol. Methods 20, 329-340 (2000).
"Photopatterning of Antibodies on Biosensors", X-H. Liu, H-K. Wang, J.N. Herron, and G.D. Prestwich, Bioconjugate Chem. 11, 755-761 (2000). William Higuchi (top) "Metastable Equilibrium Solubility Behavior of Carbonated Apatites in the Presence of Solution Fluoride", H. Zhaung, A.A. Baig, J.L. Fox, Z. Wang, S.J. Colby, A. Chhettry, and W.I. Higuchi, J. Colloid Interf. Sci., 222, 90-96 (2000).
"Calcium-level Responsive Controlled Drug Delivery from Implant Dosage Forms to Treat Osteoporosis in an Animal Model", M. Otsuka, Y. Matsuda, A.A. Baig, A. Chhettry, and W.I. Higuchi, Adv. Drug Delivery Rev., 42, 249-258 (2000). Steve Kern
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"Impact of Rocuronium and Pancuronium Interactions on the Maintenance of Neuromuscular Block During Surgery", S.E. Kern, R.J. Fragen, P.C. Fitzgerald, M. van Zeeland, and J.O. Johnson, Can. J. Anesthesia, in press.
"The Influence of Hemorrhagic Shock on Remifentanil: A Pharmacokinetic and Pharmacodynamic Analysis", K.B. Johnson, S.E. Kern, E.A. Hamber, S. McJames, G. Gong, K. Kohnstamm, and T.D. Egan, Anesthesiology, in press. Sung Wan Kim
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"Development of Biomaterials for Gene Therapy", S-O. Han, R.I. Mahato, Y.K. Sung, and S.W. Kim, Molecular Therapy, 2, 302-317 (2000). "pH Sensitive Cationic Polymer Gene Delivery Vehicle: N-Ac-Poly(L-histidine)-Graft-Poly(L-lysine) Comb Shaped Polymer, J.M. Benns, J-S. Choi, R.I. Mahato, J-S. Park, and S.W. Kim, Bioconjugate Chem., 11, 637-645 (2000). "Soluble Biodegradable Polymer-Based Cytokine Gene Delivery for Cancer Treatment", A. Maheshwari, R.I. Mahato, J. McGregor, S-O. Han, W.E. Samlowski, J-S. Park, and S.W. Kim, Molecular Therapy, 2, 121-130 (2000). "Development of a Safe Gene Delivery System Using Biodegradable Polymer, Poly[a-(4-aminobutyl)-L-gly-colic acid], Y-B. Lim, C-H. Kim, K. Kim, J.S. Park, and S.W. Kim, J. Am. Chem. Soc., 122, 6524-6525 (2000). "Thermoreversible Copolymer Gels for Extracellular Matrix", B. Vernon, S.W. Kim, and Y.H. Bae, J. Biomed. Mat. Res., 51, 69-79 (2000). "Biodegradable Polyester, Poly [a-(4-aminobutyl)-L-Glycolic Acid], As a Non-toxic Gene Carrier", Y-B. Lim, S-O. Han, H-U. Kong, Y. Lee, J-S. Park B.M. Jeong, and S.W. Kim, Pharmaceutical Res., 17, 811-816 (2000). "Tailoring New Gene Delivery Designs for Specific Target", J.M. Benns and S.W. Kim, J. Drug Targeting, 8, 1-12 (2000). "Synthesis and Characterization of Poly(ethylene glycol)-Insulin Conjugates", K. Hinds, J.J. Koh, L. Joss, F. Liu, M. Baudys, and S.W. Kim, Bioconjugate Chem., 11, 195-201 (2000). "In-situ Gelation of PEG-PLGA-PEG Triblock Copolymer Aqueous Solutions and Degradation Thereof", B-M. Jeong, Y.H. Bae, and S.W. Kim, J. Biomed. Mater. Res., 50, 171-177 (2000). "Effect of Ionic Strength on the Loading Efficiency of Model Polypeptide/Protein Drugs in pH-/Temperature- Sensitive Polymers", C.R. Ganorkar, M. Baudys, and S.W. Kim, J. Biomater. Sci. Polymer Edn., 11, 45-54 (2000). "Drug Release form Biodegradable Injectable Thermosensitive Hydrogel of PEG-PLGA-PEG Triblock Copolymers", B-M. Jeong, Y.H. Bae, and S.W. Kim, J. Controlled Release, 63, 155-163 (2000). "Effect of Molecular Weight and Polydispersity on Kinetics of Dissolution and Release from pH/Temperature-Sensitive Polymers", C.R. Ganorkar, F. Liu, M. Baudys, and S.W. Kim, J. Biomater. Sci. Polymer Edn., 10, 1149-1161 (1999).
"New Biodegradable Polymers for Injectable Drug Delivery Systems", B-M. Jeong, Y.K. Choi, Y.H. Bae, G. Zentner, and S.W. Kim, J. Controlled Release, 62, 109-114 (1999). Jindrich (Henry) Kopecek
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"HPMA Copolymer - Anticancer Drug Conjugates: Design, Activity, and Mechanism of Action", J. Kopecek, P. Kopeckova, T. Minko, and Z-R. Lu , Eur. J. Pharmaceutics Biopharm., 50, 61-81 (2000). "Antitumor Activity of HPMA Copolymer-Meso Chlorin e6 and Adriamycin Conjugates in Combination Treatments", J-G. Shiah, Y. Sun, C.M. Peterson, R.C. Straight, and J. Kopecek, Clin. Cancer Res., 6, 1008-1015 (2000). "Efficacy of Chemotherapeutic Action of HPMA Copolymer-Bound Doxorubicin in a Solid Tumor Model of Ovarian Carcinoma", T. Minko, P. Kopeckova, and J. Kopecek, Int. J. Cancer, 86, 108-117 (2000). "The Influence of Cytotoxicity of Macromolecules and of VEFG Gene Modulated Vascular Permeability on the Enhanced Permeability and Retention Effect in Resistant Solid Tumor", T. Minko, P. Kopeckova, V. Pozharov, K. Jensen, and J. Kopecek, Pharmaceutical Res., 17, 505-514 (2000). "Self-Assembled Peptides Exposing Epitopes Recognizable by Human Lymphoma Cells", A. Tang, C. Wang, R. Stewart, and J. Kopecek, Bioconjugate Chem., 11, 363-371 (2000). "Synthesis of Bioadhesive Lectin - HPMA Copolymer - Cyclosporin Conjugates", Z-R. Lu, S-Q. Gao, P. Kopeckova, and J. Kopecek, Bioconjugate Chem., 11, 3-7 (2000). "Biorecognition of HPMA Copolymer-Lectin Conjugates as an Indicator of Differentiation of Cell-Surface Glycoproteins in Development, Maturation and Diseases of Human and Rodent Gastrointestinal Tissues", S. Wroblewski, M. Berenson, P. Kopeckova, and J. Kopecek, J. Biomed. Mater. Res., 51, 329-342 (2000). "HPMA Copolymer - Anticancer Drug - OV-TL16 Antibody Conjugates. 3. The Effect of Free and Polymer-bound Adriamycin on the Expression of Some Genes in the OVCAR-3 Human Ovarian Carcinoma Cell Line", K. Kunath, P. Kopeckova, T. Minko, and J. Kopecek, Eur. J. Pharmaceutics Biopharm., 49, 11-15 (2000). "Chronic Exposure of Human Ovarian Carcinoma Cells to Free or HPMA Copolymer-Bound Mesochlorin e6 Does Not Induce P-Glycoprotein Mediated Multidrug Resistance", M. Tijerina, K. Fowers, P. Kopeckova, and J. Kopecek, Biomaterials, 21, 2203-2210 (2000). "Synthesis of Star-Like N-(2-Hydroxypropyl)-methacrylamide Copolymers - Potential Drug Carriers", D. Wang, P. Kopeckova, T. Minko, V. Nanayakkara, and J. Kopecek, Biomacromolecules, 1, 313-319 (2000). "HPMA Copolymer-Modified Avidin: Immune Response", P.R. Hart, P. Kopeckova, V. Omelyanenko, E. Enioutina, and J. Kopecek, J. Biomat. Sci., Polym. Ed., 11, 1-12 (2000). "Photodynamic Crosslinking of Proteins. V. Nature of the Tyrosine-Tyrosine Bonds Formed in the FMN-Sensitized Intermolecular Crosslinking of N-Acetyl-L-Tyrosine", H-R. Shen, J.D. Spikes, C.J. Smith, and J. Kopecek, J. Photochem. Photobiol., A: Chem., 133, 115-122 (2000). "Responsive Hybrid Hydrogels with Volume Transitions Modulated by a Titin Immunoglobulin Module", L. Chen, J. Kopecek, and R.J. Stewart, Bioconjugate Chem., 11, 734-740 (2000).
"Time- and Concentration-Dependent Apoptosis and Necrosis Induced by Free and HPMA Copolymer-Bound Doxorubicin in Human Ovarian Carcinoma Cells", M. Demoy, T. Minko, P. Kopeckova, and J. Kopecek, J. Controlled Release, 69, 185-196 (2000). Carol Lim
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"Trafficking of Nuclear Receptors in Living Cells", G.L. Hager, C.S. Lim, C. Elbi, and C.T. Baumann, J. Steroid Biochem. Mol. Biol., in press. John Mauger
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"Experimental Methods to Evaluate Diffusion Coefficients and Investigate Transport Processes of Pharmaceutical Interest", J. Mauger, In: Transport Processes in Pharmaceutical Systems, G.L. Amidon, P.I. Lee, and E. M. Topp, Eds. Marcel Dekker, 87-108 (2000). Bruce Yu
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"Rotamer Number Revealed as Another Parameter to Gauge the Quality of Packing in Folded Protein", Y.B. Yu, P. Lavigne, P.L. Privalov, and R.S. Hodges, In: Peptides for the New Millennium, G.B. Fields, J.P. Tam, and G. Barany, Eds., Kluwer Academic, Dordrecht, The Netherlands, 318-319 (2000).
FACULTY TRAVEL
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On the Road... Dr. Joe Andrade and his wife Barbara, traveled to Upsalla, Sweden in late May as the guests of Dr. Karin Caldwell, Professor of Biochemistry and Director of the Biotechnology Institute. Dr. Caldwell was formally Professor and Chair of the Department of Bioengineering at the University of Utah. Joe received an honorary doctorate degree from the University of Upsalla. He also lectured at the university's Biotechnology Institute and at the nearby BiaCore Company. In mid May, Joe traveled to Bethesda to participate in the National Center for Research Resources (NCRR) Council meeting. NCRR is a part of the National Institute of Health. The council meets three times per year to review study section and staff recommendations and to deal with other issues. On June 5th, he participated in a small meeting at Stanford University to help generate ideas and recommendations for Stanford's new Bioengineering Program, funded by the recent $150 million gift from former Stanford professor and University of Utah Computer Science alumnus, Jim Clark, the founder of Silicon Graphics, Netscape, and Healtheon. Joe also participated in the Prague Microsymposium on Biomedical Polymers, which also celebrated Professor Kopecek's 60th birthday. Joe led a panel discussion on the Future of Biomedical Polymers. On July 24th he attended the World Congress of Bioengineering and Medical Physics in Chicago, with Dr. Steve Kern. Joe presented a progress report on the Whitaker/NSF Cost Reducing Health Care Technologies project: Biosensors for the management of chronic metabolic diseases. From August 20-22 Joe participated in the International Congress on Biomedical Polymers and Drug Delivery in honor of Dr. S.W. Kim's 60th birthday on Cheju Island, Korea. Joe again led a panel discussion on the Future of Biomedical Polymers. He presented three posters on his group's current work at both the Prague and Cheju meetings. In early September he traveled to London to participate in the semiannual Scientific Advisory Panel meeting of the Smith and Nephew Corp. On October 16-17 he participated in the NIH Consensus Conference on phenylketonuria (PKU). On October 26th he went to Winona, Minnesota where he gave a lecture on the Biologization of Engineering Education to faculty and students at Winona State University. On October 27th he lectured at the Mayo Clinic in Rochester, Minnesota, on Your Private Biochemical Individuality-Development of ChemChips for Metabolome Measurement and Management. On December 8-10, Joe together with several other members of the Department of Bioengineering faculty will participate in the Whitaker Foundation summit conference on the Future of Bioengineering Education. Further information is available at: http://summit.whitaker.org/reg.html Joe is also pleased to announce that his group has located to a newly remodeled laboratory complex in the Merrill Engineering Building, which they are calling the Lab for the Modeling, Measurement, and Management of the Metabolome-the 4M Lab. Further information will be available at www.bioen.utah.edu/faculty/jda. Dr. James Herron organized and chaired a session on optical biosensors at the annual meeting of the Biomedical Optics Society (BiOS 2000). The meeting was held January 22-28, 2000 in San Jose, California. Professor Herron co-chaired a session on biosensors and presented a talk entitled "Detection of Clinical Analytes in Plasma and Whole Blood using Planar Waveguide Biosensors" at the Sixth World Biomaterials Congress. The meeting was held May 15-20, 2000 in Kamuela, Hawaii. Professor Herron visited Pharmacia in Kalamazoo, Michigan June 29th and presented a talk entitled "Fluorescent Sensing using Injection-molded Planar Waveguides". Dr. William I. Higuchi traveled extensively this past year. The highlight of his travels, was the trip to Thailand. He gave an Honorary Lecture at Mahidol University on November 24th, celebrating that University's 30th anniversary. Also while in Thailand he gave a plenary lecture at Chulalongkorn University on December 1st. Dr. Steve Kern was a Session Organizer of Children's Health Issues at the American Association for the Advancement of Science Meeting. The meeting was in Washington, D.C., February 2000. In March Steve traveled to Honolulu, Hawaii to make a presentation at the International Anesthesia Research Society Meeting on Conopeptides. In June Steve was invited to give a presentation on Transmucosal Drug Delivery at the World Congress of Anesthesia, in Montreal, Canada. During the month of July, Dr. Kern was a Session Organizer on the Cost of Healthcare Issues for World Congress in Medical Physics and Engineering, held in Chicago, Illinois. He was also a Visiting Professor at the University of Missouri, Department of Anesthesiology in Columbia, Missouri. In September, Steve traveled to Cornell University in Ithaca, New York as a Visiting Professor participating in the university's Program in Bioengineering. In October he made a presentation in the Journal Symposium at the American Society of Anesthesiologist Annual Meeting in San Francisco, California. Steve also made a presentation at the AAPS Annual meeting in November. The meeting was held in Indianapolis, Indiana. Dr. Sun Wang Kim traveled to Prague as a main lecturer for the 40th Microsymposium on Biomedical Polymers, which also celebrated Dr. Jindrich Kopecek's 60th birthday. In August a special scientific meeting was held in honor of Dr. Kim's 60th birthday in Cheju Island, Korea. The International Symposium on Biomaterials and Drug Delivery dedicated to Dr. Kim, focused on his specific contributions and seminal work in the biomedical community. Dr. Henry Kopecek was co-chair of the International Symposium on Tumor Targeted Delivery Systems held September 2000 at the National Cancer Institute in Bethesda, Maryland. Dr. Kopecek has traveled extensively this past year to participate in the following seminars, symposia, and meetings: he presented invited lectures at the Gordon Conference on Drug Carriers in Medicine and Biology in Ventura, at the University Paris-North during a two week stay as a Visiting Professor, at the Millennial World Congress of Pharmaceutical Sciences in San Francisco, at the Sixth European Symposium on Controlled Drug Delivery, Noordwijk aan Zee, The Netherlands, and at the International Symposium on Biomaterials and Drug Delivery Systems, Cheju Island, Korea (honoring Dr. S.W. Kim's 60th birthday). Henry also delivered a plenary lecture at the World Polymer Congress IUPAC MACRO 2000, Warsaw, Poland; from there he traveled to Prague to take part in the 40th Microsymposium on Biomedical Polymers, which honored his 60th birthday. He gave four lectures at a course for graduate students at the Royal Danish School of Pharmacy in Copenhagen, and lectured at Light Sciences in Seattle, Washington. In addition Henry traveled to the NIH Bioengineering and Surgery Section Meeting in Washington, D.C., and took part in the Globalization of Pharmaceutical Education Network (GPEN) meeting at the University of Uppsala, Sweden. In November Henry and his co-workers took part in the AAPS meeting in Indianapolis, Indiana. Further information on Kopecek's lab is available at: www.pharmaceutics.utah.edu/kopecek Dr. Carol Lim gave a talk in the Molecular Biology Seminar Series at BYU in February. In August, Carol traveled to NIH in Bethesda, Maryland to do some collaborative work with scientists at the NCI. In October, Carol traveled to Kalamazoo, Michigan for the Pharmacia/Upjohn Enz and Reilly Award presentations. Shortly after this, she traveled to Indianapolis, Indiana for the AAPS Annual Meeting where she presented a poster.  Wishing you Happy Holidays And a peaceful and prosperous New Year! |
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