Faculty

Joseph Andrade was awarded the title of Distinguished Professor.

Jindřich Kopeček was the recipient of the 2001 Paul Dawson Biotechnology Award from the American Association of Colleges of Pharmacy.

Carol Lim received the University of Utah College of Pharmacy Research Support Grant.

Tom Cheatham received the University of Utah College of Pharmacy Research Support Grant.

Students

Matthew Fidler . Kuramoto Fellowship

Erica Gillies . Enzon Fellowship

Sivakumar Ramachandran . Novartis Fellowship

Vijay Sethuraman . Higuchi Fellowship

Ajay Taluja . Dinesh and Kalpana Patel Fellowship

Aijun Tang . Graduate Biotechnology Research Award from the AAPS 2001

Monica Tijerina . PhRMA Foundation Predoctoral Fellowship

Kevin Warner . Walter F. Enz Award from Pharmacia Corporation

Kevin Warner . Jeffrey L. Fox Memorial Award

Kevin Warner . Elected to the Academy Executive Council for APhA

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SUMMER UNDERGRADUATE PROGRAM

The year 2001 marked the 7th year of our Summer Undergraduate Research program.  This year, we received fourteen applications and six were accepted.  They came from places as far away as Turkey and as nearby as Utah.  All six finished the program.  A presentation was given by each student at the end of the program.  SAC members took the students on trips to the surroundings of Salt Lake City.  We thank Leshia Hoffman for administering the applications and arranging the events.  We are soliciting funds for next year. s program.  If you want to contribute to this wonderful program, please contact Leshia Hoffman (801-585-0070, lhoffman@deans.pharm.utah.edu).  A summary of their topics follows:

Richard Cohen (Kim lab):  . Design, Synthesis, and Characterization of a Novel Lipopolymer Systemic Gene Delivery.

Kurt Flinders (Yu lab):  . The effect of backbone/sidechain switch on protein stability.

Stephanie Mu (Kern lab):  . Dose-Response Characterization of Conopeptide SI..

Tanya Scalise (Lim lab):  . Cellular Pharmacokinetics of Drug-receptor Complexes in Living Cells.

Spencer Thomas (Kern lab):  . Contact Lenses as Tear Collection Devices.

Timucin Ugurlu (Kopeček lab):  . Synthesis and Evolution of Biodegradable Hydrogels for Colon-specific Drug Delivery.  

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INTERNATIONAL SYMPOSIUM ON DRUG DELIVERY

This year, the Tenth International Symposium on Recent Advances in Drug Delivery Systems was held February 19-22 in the Salt Lake City Marriott Hotel.  The topics covered included protein formulation and delivery, biological and physicochemical barriers for controlled drug delivery, carriers for peptide/protein delivery, gene delivery, polymeric carriers, novel drug delivery systems, future prospects of biomaterials, and clinical aspects.  The Symposium was held in honor of James M. Anderson. s 60^th birthday.  Jim is a pioneer in the area of biomaterials, drug delivery, and biocompatibility.  The Symposium was organized by the Center for Controlled Chemical Delivery and chaired by Sung Wan Kim and Henry Kopeček.  Over 300 participants from all over the world attended the outstanding meeting.

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ALUMNI NEWS

AAPS Breakfast

The annual meeting of the American Association of Pharmaceutical scientists was held in the beautiful . Mile High City. (Denver) this October. It was a very enriching experience to come together with pharmaceutical scientists from all around the globe to share views and opinions on a common platform. The fame of the University of Utah traveled far, as one of our graduate students, Aijun Tang, won a prestigious award at this meeting. The highlight of the meeting was the 2001 annual alumni breakfast, which was a huge success. It was a morning of fun, laughter, meeting past friends and colleagues, good food and nostalgic trips down memory lane. Dr. Bruce Yu was formally introduced to the gathering, as this was the first time he was attending this meeting as an assistant professor in our department.  The turnout at the breakfast year was unexpectedly high, with more than 80 people attending. Well, the more the merrier and it was a morning worth cherishing.  Till we meet again next yearkudos to the Department of Pharmaceutics & Pharmaceutical Chemistry, University of Utah!!

2001 AAPS Alumni Breakfast in Denver, CO

Alumni Highlights

Dr. Todd. Richard T. Darringtonis currently Assistant Director in Pharmaceutical Research & Development at the Groton Laboratories of Pfizer Inc., and Adjunct Associate Professor at the University of Connecticut, College of Pharmacy. He received his B.S. in Chemistry, magna cum laude, from the University of Utah in 1988, and a Ph.D. in Pharmaceutical Chemistry from the University of Utah under the tutelage of Dr. Bradley D. Anderson in 1993.

Dr. Darrington's first experience with the Department of Pharmaceutics and the College of Pharmacy came about during his junior year in the Chemistry program.  Hearing about a Pharmaceutics summer scholarship program, he applied, and was accepted.  During that summer, he worked with Dr. Jeff Fox on the development of a computer program to simulate a molecule. s movement through a bilayer.  This was his first exposure to the application of chemistry to the field of drug development and delivery and . I was hooked. .  During that summer he also had the opportunity to meet his future graduate advisor, Dr. Brad Anderson. Dr. Anderson convinced him to continue his education and work towards a doctoral degree in Pharmaceutics.  . Dr. Anderson has been a great mentor and I now consider him a true friend.  I still call him for advice from time to time and owe all of my accomplishments to his guidance..   . The excellent instructors who made up the department also had a lot to do with my success.  The curriculum at the University of Utah Department of Pharmaceutics was, and is, recognized as one of the best in the world..

In 1993 Dr. Darrington joined Glaxo Inc. where he focused on the development of parenteral and enteral dosage forms of small and macromolecules in the Pharmaceutical Research & Development group, Research Triangle Park, NC.

Dr. Darrington joined Pfizer in 1995. Research interests include development of novel dosage forms for human and veterinary applications, protein controlled release, prediction of protein stability from accelerated data, development of more accurate methods to predict drug degradation, kinetics and mechanisms of drug degradation, and development of formulations and manufacturing process for palatable oral dosage forms for veterinary medicine. 

Dr. Darrington and his wife, Linda, very much enjoy the Northeast and have recently taken up power and sail boating in the Long Island Sound.  . The ocean is a marginally acceptable substitute for the gorgeous Wasatch Mountain Range and the Southern Utah Deserts..   They have one Daughter, Jamie, who is in her second year of college.  Although they miss living in Utah, they do find time to return on a regular basis, and they remain committed Utah Jazz fans.  . I already have tickets for the Jazz versus Boston and New Jersey games for this season..

Dr. David Putnam  Following the defense of his thesis in January, 1996, Dr. Putnam took some time with his wife, Kathy.  They bicycled the Pacific coast from Canada to Mexico.  . Kathy dreamed of biking across the country from West to East whereas I dreamed of actually having a job.  The coast was a nice compromise, and we spent several weeks homeless and unemployed camping down the coast and meeting all sorts of great people.  The terrain spanned from the rainforest of Washington to the 110⁰ F scorch of Napa Valley.  If you ever have the opportunity for such a trip, do not pass it up!.   . Upon re-establishing ourselves with reality, we moved to Cambridge, MA where I joined the laboratory of Dr. Robert Langer in the Department of Chemical Engineering at MIT for a postdoctoral fellowship focusing on the design and synthesis of non-viral gene delivery systems.. Dr. Putnam described this experience as an excellent fit with the training he received in Dr. Kopeček. s laboratory. 

While in Dr. Langer. s laboratory, he was fortunate to help develop some ideas about how to formulate pharmaceuticals in an efficient and cost-effective manner.  The reduction of these ideas to practice in collaboration with some outstanding people from Millenium Pharmaceuticals resulted in the founding of TransForm Pharmaceuticals in October 1999. 

As time progressed, he realized he needed to make some changes in his life.  His wife Kathy decided it was time to begin a regular exercise routine. Kathy proposed taking up the sport of triathlon.  . Being essentially non-swimmers and mediocre bikers, Kathy and I began to train and eventually became able to race with limited success.  Culminating this effort, we completed Ironman USA, held in Lake Placid NY, in 1999 and 2001 and are set to race again in 2002..   Kathy also began to bike race on the collegiate circuit and finished 33^rd in the nation at the 2001 Collegiate National Cycling Championships!

In parallel to these events, Kathy decided to return to school and joined the doctoral program in Pharmacoepidemiology at the Harvard School of Public Health.  With an intriguing opportunity to help build a company, combined with his wife. s desire to further her education, he made the decision to join the company.  TransForm now employs over 50 people and is positioned for another growth phase in the very near future.

In August 2002, Dr. Putnam and his wife will move to Ithaca, NY.  He will join the Department of Chemical and Biomolecular Engineering at Cornell University as an assistant professor and Kathy will join the Division of Nutritional Sciences as a postdoctoral fellow studying the effects of food on medicine.  . There may be a trip or two stuck in somewhere along the line, but that will have to wait for next year. s . U. newsletter..

Dr. Steve Wisniewski  After receiving his Ph.D. under the advisement of Dr. Sung Wan Kim and leaving the U in 1980, Dr. Wisniewski joined the faculty at the University of Connecticut  School of Pharmacy, first as a Postdoctoral Fellow and then as Assistant Professor in Residence.  In 1982, Steve moved to Pennsylvania, beginning a 19 year career with Johnson & Johnson at McNeil Consumer Products Company. In his six years at McNeil, he focused on dermal, transdermal and long acting suspension delivery systems as well as tamper resistant packaging.   Steve received the company's highest award, The APEX  Award, for his efforts on tampering detection associated with the Tylenol poisoning in 1986.  He transferred to Johnson & Johnson Baby Products Company (currently J&J Consumer Products Companies) in 1988. 

Over the last 13 years at J&J Consumer Products Company, Steve has worked on in vitro skin permeation and in vitro release methods development, acne products claims support, wound healing, Rx dermal products preformulation and formulation, two compartment packaging, and the evaluation of transdermal drug delivery for human and veterinary use. He is a coinventor on 6 US patents. Steve currently lives in Southeastern Pennsylvania with his wife, Linda, a writer and librarian, his son, Matthew, a sixth grade student, and his stepson, Aaron, who is living on his own.   

Dr. Ping-Yang Yeh graduated in 1984 from Tamkang University, Taiwan, with a B.S. degree in Chemical Engineering.  In 1988, he entered the graduate program in Material Sciences and Engineering in the University of Utah under the supervision of Professor Joseph Andrade.  Following his M.S. in 1990, he joined Professor Kopeček's group and finished his Ph.D. in Pharmaceutics and Pharmaceutical Chemistry in 1994.  His thesis focused on the development of a colon-specific oral delivery system for protein and peptide and the understanding of transport mechanism of macromolecule across intestinal epithelium mucosa.  Afterwards, he stayed as a post doctoral fellow in Dr. Kopeček's lab, during which time he initiated a new project with the aim to understand intracellular trafficking of polymer-bound antisense oligonucleotides following uptake by hepatocytes.  In Nov 1995, he joined SmithKline Beecham Pharmaceutical R&D in the Drug Delivery Department, King of Prussia, PA.

Ping had the responsibility to work at the interfaces between pre-clinical development and discovery research on drug candidate selection.  This involved early assessment of drug molecules from three different aspects, including physicochemical properties, mechanism of intestinal transport, and drug delivery.  The goals of these efforts were to ensure the developability of drug molecule in the clinic.  Ping had a major impact on two discovery programs in terms of helping the discovery teams to identify key structural templates that would provide drug candidates with appropriate pharmaceutics and pharmacokinetic properties.  As a result, he was awarded with two Bronze Impact Awards in 1996 and 1999, respectively, given by Pharmaceutical Development R&D.  Dr. Yeh said "the solid scientific training that I received in Utah has provided me with solid scientific background to quickly pin down key issues underlying the molecules".  During his tenure in Drug Delivery Department from 1996-2000, Dr. Yeh had also published four book chapters, five journal articles, six abstracts, and given four invited presentations.  He had also supervised the thesis research of three master students from Netherlands and Denmark.

Earlier this year, Dr. Yeh moved into Biopharmaceutical Development in the newly merged company, GlaxoSmithKline Pharmaceuticals.  At present, he is an Assistant Director and leads a group of scientists with the responsibilities in formulation development for protein therapeutics as well as in the monitoring of the progress drug candidates through different phases of clinical trials (Phase I to Phase III).  In his current role, he continues to work with Discovery Research and co-lead drug discovery activities in identifying drug delivery approaches for sustained protein delivery with the goals to improve pharmacodynamic and pharmacokinetic properties of the molecule.  He was awarded the Silver Impact Award in 2000 for the recognition of his work in progressing one of such activities from idea on the bench to proof-of-concept in the pre-clinical animal models. 

Dr. Yeh is happily married with his wife, Lo-Mei, and two children, Alvin and Alice; both were born in Salt Lake City.  He shared that "the most memorable part of my life is definitely during those days in Utah.  Those memories often come back just as yesterday.  I was very fortunate to be part of Utah's program.   I not only learned about sciences but also had the opportunity to work with world first class researchers in the pharmaceutical area.  I truly believe that the multidiscipline program in Utah with the emphasis on basic understanding of physical chemistry, polymeric drug delivery, and cellular/molecular biology really equip student with broader aspects of pharmaceutics and drug delivery.  And such training also provides student with excellent knowledge asset as well as scientific network to ensure the success of their career in either academic or industry".

Dr. Anna Gutowska graduated from the University of Warsaw, Poland in 1978 with Masters degree in chemistry, specializing in polymers. The same year she started working at the Institute of Industrial Chemistry, Warsaw, Poland, in the area of medical applications of polymeric materials.

In the summer of 1987 Anna and her family moved to US, where her husband, Maciej Gutowski, accepted a postdoctoral position at the University of Utah, Chemistry Department, with Professor Jack Simons. In the fall of 1987, Anna took a position of a Research Assistant, at the Center for Controlled Chemical Delivery and Department of Pharmaceutics, University of Utah, working initially in the area of polymeric surfactants, under the guidance of Professor Sung Wan Kim and Professor Henry Kopeček.

In 1989 she was accepted as a graduate student at the Department of Pharmaceutics and Pharmaceutical Chemistry, and began studies of her favorite (to this day!) stimuli-responsive polymers under the supervision of Professor Sung Wan Kim and in collaboration with Dr.You Han Bae. She focused her thesis on heparin releasing thermosensitive hydrogels and published 4 papers in this area. After graduating in 1994, Anna remained at the Department for 1.5 more years as a Research Associate, and continued working with Professor Sung Wan Kim on hydrogels for controlled oral drug delivery.

In the winter of 1995, the whole family moved to Richland, Washington where Anna and Maciej accepted positions at the Pacific Northwest National Laboratory (PNNL). Anna joined the Materials Sciences Department, and Maciej joined the Theory, Modeling, and Simulation Group. To this day, they are both pursuing their carriers at PNNL. Anna continues to develop stimuli-responsive polymers for various medical applications and received grants for her studies from the US Department of Energy, National Institutes of Health, the US Department of Defense, and numerous PNNL/Laboratory Directed Research and Development Grants. Her research is focusing now on materials for delivery of therapeutic agents including localized delivery of medical radioisotopes, and materials for bone and cartilage repair. Over the years, she published 16 papers and co-authored 8 patent applications, from which two US and one Polish patent are granted. Anna believes that the training that she received at the University of Utah, gave her a great foundation to conduct research in the area of drug delivery and tissue engineering.

The Gutowski family enjoys living in Pacific Northwest. Their daughter Magda is a junior at the Evergreen State College in Olympia, successfully majoring in Environmental Studies, and their son Michal is a junior at Hanford High School, a member of the National Honor Society and a long-distance runner.

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ACTIVE NIH/DOD GRANTS

NIH Grant DK56884; Bioactive Polymers for Effective Islet Delivery System, Y.-H. Bae, PI.

NIH Grant HL32132; Multi-analyte Waveguide Immunosensing; J.N. Herron, PI.

NIH Grant DE06569; Quantitation of Enamel Demineralization Mechanisms, W.I. Higuchi, PI.

NIH Grant DK51689; Anti-GAD MAB Polymer Conjugates for Diabetes Treatment, S.W. Kim, PI.

NIH Grant H/L65477; Functional and Targeting Polymeric Gene Carriers, S.W. Kim, PI.

NIH Grant CA88047; Targeting to Lymphocytes Mediated by Synthetic Epitopes; J. Kopeček, PI.

NIH Grant CA51578; A Polymeric Drug Delivery System for Cancer Therapy; J. Kopeček, PI.

NIH Grant GM50839; Degradable Hydrogels for Oral Delivery of Calcitonin; J. Kopeček, PI.

NIH Grant DK39544; Bioadhesive Polymers for Treatment of Colon Disease; J. Kopeček, PI.

DOD Grant Agonist-Occupied PRA Represses PRB via Interactions with Coactivators or Corepressors; C. Lim, PI.

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PAPERS PUBLISHED IN 2001

You Han Bae

H. Gappa, M. Baudys, J.J. Koh, S.W. Kim, Y.H.Bae, "The Effect of Zinc-crystallized Glucagon-like-1 on Insulin Secretion of Encapsulated Pancreatic Islets," Tissue Eng., 7, 35-44 (2001).

N. Baek, J.H. Park, Y.H. Bae, K. Park, "Control of the Swelling Rate of Superporous Hydrogels," J. Bioactive and Compatible Polymers, 16, 47-57 (2001).

K.-H. Park, S.W. Kim, Y.H. Bae, "Interaction of Sulfonylurea-Conjugated Polymer with Insulinoma Cell Line of MIN6 and its Effect on Insulin Secretion," J. Biomed. Mater. Res., 55, 72-78 (2001).

S.I. Kang, Y.H. Bae, "pH-Temperature-Sensitive Polymer: Poly(N-isoprolyacrylamide-co-methacyloylated sulfamethoxypyridazine)," Macromol. Chem. Symp. (Korea), 14, 145-155 (2001).

J.H. Park, K.B. Lee, I.C. Kwon, Y.H. Bae, "PDMS-Based Polyurethanes with MPEG Grafts: II. Mechanical Characterization, Bacterial Repellency and Release Behavior of Rifampicin," J. Biomater. Sci., Polym. Edn., 12, 629-645 (2001).

Y.H. Bae, S.I. Kang, K. Na, "Sulfonamide Containing Polymers: A New Class of pH-Sensitive Polymers and Gels," Macromol. Symp., 172, 149-156 (2001).

K.-H. Park, J.Y. Park, Y.H. Bae, "Phenotype of Hepatocyte Spheroids in Synthetic Thermo-Reversible Extracellular Matrix," Biotech. Bioproc. Eng. (Korea), 6, 264-268 (2001).

S.I Kang, Y.H. Bae, "pH-Induced Volume-Phase Transition by Reversible Crystal Formation," Macromolecules, 34, 8173-8178 (2001).

William Higuchi

K.S. Warner, S.K. Li, W.I. Higuchi, "Influences of the Alkyl Group Chain Length and the Polar Head Group on Skin Chemical Permeation Enhancement," J. Pharm. Sci., 90, 1143-1153 (2001).

H. Zhu, K.D. Peck, S.K. Li, A-H Ghanem, W.I. Higuchi, "Quantification of Pore Induction in Human Epidermal Membrane During Iontophoresis: Importance of Background Electrolyte Selection," J. Pharm. Sci., 90, 932-942 (2001).

S.K. Li, A-H Ghanem, C-L Teng, G.E. Hardee, W.I. Higuchi, "Iontophoretic Transport of Oligonucleotides Across Human Epidermal Membrane," J. Pharm. Sci., 90, 915-931 (2001).

Steve Kern

K.B. Johnson, S.E. Kern, E.A. Hamber, S. McJames, G. Gong, K. Kohnstamm, T.D. Egan, "The Influence of Hemorrhagic Shock on Remifentanil: A Pharmacokinetic and Pharmacodynamic Analysis," Anesthesiology, 94, 322-32 (2001).

S.E. Kern, R.J. Fragen, P.C. Fitzgerald, M. vanZeeland, J.O. Johnson, "Impact of Rocuronium and Pancuronium Interactions on the Maintenance of Neuromuscular Block During Surgery," Can. J. Anesthesia, 48, 129-32 (2001).

T.A. Burns, T.S. Shomaker, B.C.K. Patel, A. Crandall, N.L. Pace, S.E. Kern, N.J. Satovick, G.J.P. Meyfroidt, "A Comparison of Oral Transmucosal Fentanyl Citrate, and Intravenous Fentanyl Citrate for Perioperative Sedation/Analgesia for Cataract Surgery," Am. J. Anesthesiology, 28, 15-19 (2001).

Sung Wan Kim

L. Yu, H. Suh, J.J. Koh, S.W. Kim, "Systemic Administration of TerplexDNA System: Pharmacokinetics and Gene Expression," Pharmaceutical Research, 18, 1277 (2001).

K.S. Ko, M. Lee, J.J. Koh, S.W. Kim, "Combined Administration of IL-4 and IL-10 Plasmids to Prevent the Development of Autoimmune Diabetes in NOD Mice," Molecular Therapy, 4, 313 (2001).

J.M. Benns, A. Maheshwari, D.Y. Furgeson, R.I. Mahato, S.W. Kim, "Folate-PEG-Folate-Graft-Polyethylenimine-Based Cytokine Gene Delivery," J. Drug Targeting, 9, 123 (2001).

M. Lee, S.-O. Han, K.S. Ko, J.J. Koh, J.-S. Park, J.-W. Yoon, S.W. Kim, "Repression of GAD Autoantigen Expression in Pancreas Cell by Delivery of Antisense Plasmid/PEG-g-PLL Complex," Molecular Therapy, 4, 339 (2001).

D.S. Lee, M.S. Shim, H. Lee, I. Park, T. Chang, S.W. Kim, "Novel Thermoreversible Gelation of Biodegradable PLGA-block-PEO-block-PLGA Triblock Copolymers in Aqueous Solution," Macromolecular Rapid Communications, 22, 487 (2001).

M. Lee, S.O. Han, K.S. Ko, S.W. Kim, "Cell Type Specific and Glucose Responsive Expression of Interleukin-4 by Using Insulin Promoter and Water Soluble Lipoplymer," J. Control Release, 75, 421 (2001).

R.I. Mahato, M. Lee, S.-O. Han, A. Maheshwari, S.W. Kim, "Intratumoral Delivery of p2CMVmIL-12 Using Water-Soluble Lipopolymers," Molecular Therapy, 4, 130 (2001).

L. Yu, M. Nielsen, S.-O. Han, S.W. Kim, "TerplexDNA Gene Carrier System Targeting Artery Wall Cells," J. Control Release, 72, 179 (2001).

W. Suh, J.-K. Chung, S.-H. Park, S.W. Kim, "Anti-JL1 Antibody-Conjugated Poly (L-lysine) for Targeted Gene Delivery to Leukemia T Cells," J. Control Release, 72, 171 (2001).

S.C. Kim, D.W. Kim, Y.H. Shim, J.S. Bang, H.S. Oh, S.W. Kim, M.H. Seo, "In Vivo Evaluation of Polymeric Micellar Paclitaxel Formulation: Toxicity and Efficacy," J. Control Release, 72, 191 (2001).

Y.J. Kim, S. Choi, J.J. Koh, M. Lee, K.S. Ko, S.W. Kim, "Controlled Release of Insulin from Injectable Biodegradable Triblock Copolymer," Pharmaceutical Research, 18, 548 (2001).

M.H. Lee, J.W. Nah, Y.M. Kwon, J.J. Koh, K.S. Ko, S.W. Kim, "Water-Soluble and Low Molecular Weight Chitosan-Based Plasmid DNA Delivery," Pharmaceutical Research, 18, 427 (2001).

S.-O. Han, R.I. Mahato, S.W. Kim, "Water-Soluble Lipopolymer for Gene Delivery," Bioconjugate Chemistry, 12, 337 (2001).

D.G. Affleck, L. Yu, D.A. Bull, S.H. Bailey, S.W. Kim, "Augmentation of Myocardial Transfection Using TerplexDNA: A Novel Gene Delivery System," Gene Therapy, 8, 349 (2001).

H. Gappa, M. Baudys, J.J. Koh, S.W. Kim, Y.H. Bae, "The Effect of Zinc-Crystallized Glucagon-Like Peptide-1 on Insulin Secretion of Macroencapsulated Pancreatic Islets," Tissue Engineering, 7, 35 (2001).

K.H. Park, S.W. Kim, "Interaction of Sulfonylurea Conjugated Polymer with Insulinoma Cells," J. Biomed. Mater. Res., 55, 72 (2001).

Jindřich (Henry) Kopeček

J. Kopeček, P. Kopečková, T. Minko, Z.-R. Lu, C.M. Peterson, "Water Soluble Polymers in Tumor Targeted Delivery," J. Contr. Rel., 74, 147-158 (2001).

J.-G. Shiah, M. Dvorak, P. Kopečková, Y. Sun, C.M. Peterson, J. Kopeček, "Biodistribution and Antitumor Efficacy of Long-Circulating N-(2-Hydroxypropyl)methacrylamide Copolymer-Doxorubicin Conjugates in Nude Mice," Eur. J. Cancer, 37, 131-139 (2001).

T. Minko, P. Kopečková, J. Kopeček, "Preliminary Evaluation of Caspases -Dependent Apoptosis Signaling Pathways of Free and HPMA Copolymer-Bound Doxorubicin in Human Ovarian Carcinoma Cells," J. Contr. Rel., 71, 227-237 (2001).

A. Tang, C. Wang, R.J. Stewart, J. Kopeček, "The Coiled Coil in the Design of Protein-Based Constructs: Hybrid Hydrogels and Epitope Displays," J. Contr. Rel., 72, 57-70 (2001).

J.-G. Shiah, Y. Sun, P. Kopečková, C.M. Peterson, R.C. Straight, J. Kopeček, "Combination Chemotherapy and Photodynamic Therapy of Targetable N-(2-Hydroxypropyl)methacrylamide Copolymer Doxorubicin/Mesochlorine₆ OV-TL16 Antibody Immunoconjugates," J. Contr. Rel., 74, 249-253 (2001).

Y. Kasuya, Z.-R. Lu, P. Kopečková, J. Kopeček, "Improved Synthesis and Evaluation of 17-Substituted Aminogeldanamycin Derivatives, Applicable to Drug Delivery Systems," Bioorg. Med. Chem. Lett., 11, 2089-2091 (2001).

Z.-R. Lu, S.-Q. Gao, P. Kopečková, J. Kopeček, "Modification of Cyclosporin A and Conjugation of its Derivative to HPMA Copolymers," Bioconjugate Chem., 12, 129-133 (2001).

C. Wang, J. Kopeček, R.J. Stewart, "Hybrid Hydrogels Crosslinked by Genetically Engineered Coiled-coil Block Proteins," Biomacromolecules, 2, 912-920 (2001).

S. Sakuma, Z.-R. Lu, P. Kopečková, J. Kopeček, "Biorecognizable HPMA Copolymer-Drug Conjugates for Colon-Specific Delivery of 9-Aminocamptothecin," J. Contr. Rel., 75, 365-379 (2001).

J. Kopeček, A. Tang, C. Wang, R.J. Stewart, "De Novo Design of Biomedical Polymers: Hybrids from Synthetic Macromolecules and Genetically Engineered Protein Domains," Macromolecular Symposia, 174, 31-42 (2001).

L. Varticovski, Z.-R. Lu, I. De Aos, K. Mitchell, R. Christensen, J. Kopeček, "A Water-Soluble HPMA Copolymer Wortmannin Conjugate Retains Phosphoinositide 3-Kinase Inhibitory Activity In Vitro and In Vivo," J. Contr. Rel., 74, 275-281 (2001).

Y. Kasuya, Z.-R. Lu, P. Kopečková, T. Minko, S.E. Tabibi, J. Kopeček, "Synthesis and Characterization of HPMA Copolymer Aminopropylgeldanamycin Conjugates," J. Contr. Rel., 74, 203-211 (2001).

K.D. Fowers, J. Callahan, P. Byron, J. Kopeček, "Preparation of Fab from Murine IgG_2a for Thiol Reactive Conjugation," J. Drug Targeting, 9, 281-294 (2001).

S. Wroblewski, B. Rihova, P. Rossmann, T. Hudcovicz, Z. Rehakova, P. Kopečková, J. Kopeček, "The Influence of a Colonic Microbiota on HPMA Copolymer Lectin Conjugates Binding in Rodent Intestine," J. Drug Targeting, 9, 85-94 (2001).

M. Tijerina, P. Kopečková, J. Kopeček, "The Effects of Subcellular Localization of N-(2-Hydroxypropyl)methacrylamide Copolymer-Mce₆ Conjugates in a Human Ovarian Carcinoma," J. Contr. Rel., 74, 269-273 (2001).

S. Wroblewski, M. Berenson, P. Kopečková, J. Kopeček, "The Effects of Subcellular Localization of N-(2-Hydroxypropyl)methacrylamide Copolymer-Mce₆ Conjugates in a Human Ovarian Carcinoma," J. Contr. Rel., 74, 283-293 (2001).

Z.-R. Lu, J.-G. Shiah, P. Kopečková, J. Kopeček, "Preparation and Biological Evaluation of Polymerizable Antibody Fab Fragment Targeted, Polymeric Drug Delivery System," J. Contr. Rel., 74, 263-268 (2001).

C. Wang, R.J. Stewart, J. Kopeček, "Genetically Engineered Protein Domain as Crosslinks in Hydrogels," In: Polymeric Drugs & Delivery Systems, (R.M. Ottenbrite, S.W. Kim, Eds.), Technomics Publishing Co., Lancaster, PA, 131-143 (2001).

Z.-R. Lu, P. Kopečková, J. Kopeček, "Semitelechelic Poly[N-(2-hydroxypropyl)methacrylamide] for Biomedical Applications," In: Polymeric Drugs & Delivery Systems, (R.M. Ottenbrite, S.W. Kim, Eds.), Technomics Publishing Co., Lancaster, PA, 1-14 (2001).

T. Minko, P. Kopečková, J. Kopeček, "Mechanism of Anticancer Action of HPMA Copolymer-Bound Doxorubicin," Macromolecular Symposia, 172, 35-47 (2001).

A. David, P. Kopečková, A. Rubinstein, J. Kopeček, "Enhanced Biorecognition and Internalization of HPMA Copolymers Containing Multi- or Multivalent Carbohydrate Side-Chains by Human Hepatocarcinoma Cells," Bioconjugate Chem., 12, 890-899 (2001).

Carol Lim

C.T. Baumann, H. Ma, R. Wolford, J. Reyes, P. Maruvda, C. Lim, P.M. Yen, M.R. Stallcup, G.L. Hager, "The Glucocorticoid Receptor Interacting Protein 1 (GRIP1) Localizes in Discrete Nuclear Foci that Associate with ND10 Bodies and Are Enriched in Components of the 26S Proteasome," Molecular Endocrinology, 15, 485-400 (2001).

Bruce Yu

Y.B. Yu, K.C. Wagschal, C.T. Mant, R.S. Hodges, "Trapping the Monomeric a-Helical State During Unfolding of Coiled-coils by Reversed-Phase Liquid Chromatography," J. Chromatogr. A, 890, 81-94 (2000).

J. Taylor, B. Wu, N.J. Greenfield, Y.B. Yu, P.L. Privalov, "A Calorimetric Study of the Helix-Coil Transition Using a Side-Chain Bridged Peptide that Folds and Unfolds Cooperatively," In: Peptides for the New Millennium, (G.B. Fields, J.P. Tam & G. Barany, Eds.), Kluwer Academic, Dordrecht, The Netherlands, 280-282 (2000).

Y.B. Yu, P.L. Privalov, R.S. Hodges, "Contribution of Translational and Rotational Motions to Molecular Association in Aqueous Solution," Biophys. J., 81, 1632-1642 (2001).

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FACULTY TRAVEL

On the Road

Dr. Steven Kern was invited to a presentation on Response Surface Remodeling at the International Society for Anaesthesia Pharmacology meeting in New Orleans, LA in October.  He also attended a course in Modeling Complex System in Molecular Biology at Santa Fe Institute this summer.

Dr. Sung Wan Kim took sabbatical leave in the Fall semester of 2001.  He initiated collaborative research with clinicians at Seoul National University Hospital, Seoul, Korea.

Dr. Henry Kopeček traveled extensively this year. In February he traveled to Bethesda, MD to take part in the meeting of the NIH Surgery and Bioengineering Study Section.  The same month Henry and Sung Wan Kim co-organized the Tenth International Symposium on Recent Advances in Drug Delivery Systems in Salt Lake City. 

In March Henry traveled to Paris to present a lecture at the symposium  . New Trends in Polymers for Oral and Parenteral Administration: From Design to Receptors. organized by the European Federation of Pharmaceutical Sciences.  From Paris Henry and Pavla went to Prague to pursue collaborative work in the Czech Academy of Sciences. 

In May Henry gave four lectures at a course for graduate students at the Royal Danish School of Pharmacy in Copenhagen.  The highlight of this stay was the interaction with Danish graduate students and the discussion of their Ph.D. thesis topics and progress.  At the end of May Henry presented a lecture on genetically engineered biomaterials at the . 4^th International Meeting on the Frontiers in Biomedical Polymers. in Williamsburg, Virginia.

In June Henry and all coworkers took part in the . 28th International Symposium on Controlled Release of Bioactive Materials. in San Diego, California.  Henry and Pavla gave invited lectures; posters of three students, J. Callahan, H. Ding, and A. Nori were selected for podium presentations.  During the meeting we organized a dinner for present and past lab members.  Thirty-five people took part . it was great to see all.

In July Henry took part in the American Association of Colleges of Pharmacy 2001 Meeting, in Toronto, Canada to accept the Paul Dawson Biotechnology Award and to present a lecture.  From Toronto Henry and Pavla continued to New London, New Hampshire where Henry lectured at the Gordon Research Conference on Polymers.

In October, Henry lectured at the 16^th Annual Meeting of the American Association of Pharmaceutical Scientists in Denver, Colorado. Aijun Tang from our laboratory received the Graduate Biotechnology Award.  Many members of our Department took part in the meeting and in the Alumni and Friends breakfast (see above).

At the end of the year Henry traveled to Geltex in Waltham, Massachusetts and to Access Pharmaceuticals in Dallas, Texas.

Dr. Carol Lim traveled to the 2001 AAPS National Meeting in Denver, CO to present a poster entitled . Differential Localization of the Human Progesterone Receptor: Is a Nuclear Export Signal Involved?.

Dr. James Herron  attended, in Janaury 2001, BiOS 2001 (annual meeting of the Biomedical Optics Society).  At the meeting, he chaired a podium session entitled . Optical Biosensor Systems..  

During March 2001, Prof. Herron visited Prof. Monty Reichert at Duke University, where he gave a presentation entitled . Rapid Medical Diagnostic Assays using Planar Waveguide Fluorescent Sensors..  

On the way back from Duke, he stopped off in Minneapolis-St. Paul for a few days to visit UUtah alumni Drs. Ai-ping Wei and Jie Liu, who both work at 3M Corporation.  While at 3M, Prof. Herron gave a presentation entitled . Mix and Read Fluorescent Immunoassays based on Synthetic Peptide Antigens..   While in Minnesota, Prof. Herron also visited Medtronic, Inc. and gave a presentation entitled . Rapid Medical Diagnostic Assays using Planar Waveguide Fluorescent Sensors..  

In October, Jermey Guo (a graduate student in Herron. s group) presented a poster entitled . Rapid Throughput Screening of K_sp Values for Weakly Basic Drugs Using 96-well Format. at the annual AAPS meeting in Denver.  This work resulted from Jeremy. s industrial internship at Pharmacia Corporation in Kalamazoo, MI.  Drs. Paul Elzinga and Michael Hageman from Pharmacia were co-authors of the poster.  Dr. Hageman is an Adjunct Professor of Pharmaceutics at UUtah and also a member of Jeremy. s supervisory committee.

Dr. Bruce Yupresented a poster entitled "Contribution of Translational and Rotational Motions to Molecular Association in Aqueous Solution" at the 2001 AAPS National Meeting in Denver in October.

Bruce Yu accompanied Kevin Warner (student of Dr. William Higuchi) to Kalamazoo, Michigan in early November.  Kevin Warner is the recipient of 2001 Enz Award in Pharmaceutics.  Kevin gave a talk entitled "Understanading the Contributions of the Alkyl Group Chain Length and the Polar Head Group on Chemical Skin Permeation Enhancement" which was well received.

Pharmaceutics & Pharmaceutical Chemistry

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Salt Lake City, UT 84112

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