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Department of Pharmaceutics & Pharmaceutical Chemistry
College of Pharmacy 301 Skaggs Hall 30 South 2000 East Salt Lake City, UT 84112 phone: (801) 581-7831 fax: (801) 581-3674 |
Newsletter
Department of Pharmaceutics and Pharmaceutical Chemistry December, 2002 Also available in PDF Volume 4 Contents:
Welcome to the fourth issue of our Newsletter! I am writing this column after meeting many of you at the Department Alumni and Friends Breakfast during the AAPS meeting in Toronto and at the GPEN (Globalization of Pharmaceutical Education Network) meeting in Ann Arbor, Michigan. I hope we shall keep in touch during the next year.Numerous activities occurred this year. The new graduate curriculum, described in the last Newsletter, was successfully implemented, as well as the modified Ph.D. qualifying examination. We are now working on the joint Pharm.D./Ph.D. and M.D./Ph.D. programs and on a joint Ph.D. program in bioengineering and pharmaceutics. These changes and efforts were well received by the students; it appears that we have succeeded in further improving the rigorous preparation of our students for their jobs in academia and industry. Based on the discussions at the faculty retreat in the summer of 2001,I have charged the Strategic Planning Committee (S.W. Kim, J. Herron, and S. Kern) to address topics important for the future of the Department and have prepared a draft for discussion. I am happy to report that after several rounds of discussion, input from faculty and graduate students, the new Strategic Plan of our Department was recently approved at our faculty meeting. Examples of topics addressed are:
For the past few years the department has made an important move in the direction of basic research. Our areas of excellence are Macromolecular Therapeutics and Biomolecular and Cellular Pharmaceutics. Exciting research goes on in the Department in the areas of: delivering anticancer drugs, oligonucleotides, and genes, genetically engineered and cell-based biomaterials for drug delivery, biorecognition, imaging, cellular and membrane transport, and the mathematical modeling of cellular and subcellular processes. You will get a glimpse of what is going on in the papers published by our faculty shown at the end of this Newsletter. Before initiating the Strategic Planning process, I announced that I plan to step down as Chairman on June 30, 2004 when my current term expires. We shall appoint a Search Committee in the Spring 2003. We are aware that we will have to secure an endowed chair to attract excellent candidates. Today, there is an exciting atmosphere in the Department. The six faculty who came on board since 2000 have vitalized the Department. We have implemented a new mentoring system for young faculty to assist them in their development. At present there are 45 Ph.D. students in the Department. Thirty seven are Pharmaceutics students, 8 are students from other Departments who are mentored by our faculty. In total there are more than 100 people in the Department. This includes 17 postdoctoral fellows/research associates, research faculty, visiting faculty, exchange and rotating students, and staff. Just now there are exchange students from the Philipps University, Marburg, Germany, University of Kuopio, Finland, Kwanju Institute of Technology, Korea, and Mahidol University, Bangkok, Thailand in our laboratories. Such an excellent operation is possible only due to the effort of our faculty in securing research funding from peer-reviewed federal agencies and from industry. The faculty grant support is over $3 million per year. Based on the evaluation of recent grant proposals, this number will soon increase dramatically. The students participate in all activities of the department. Members of the Student Advisory Committee take part in faculty meetings and in the RPT (retention, promotion, tenure) evaluation process of our faculty. Seven of our graduate students took part in the GPEN conference in Ann Arbor and represented the level of education at Utah well. Numerous graduate students presented their research results at national and international scientific meetings. The summer undergraduate research program continued this summer very successfully. Nine students spent 10 weeks in our laboratories (see report below). We look forward to interactions with you during the next year. Please, support our continual efforts. I encourage you to visit our Department website at www.pharmaceutics.utah.edu. News from the Department and all previous Newsletters are accessible at this address. Finally, I would like to thank Ron Richins for the design and production of this Newsletter. The faculty, students and staff wish all alumni and friends a Merry Christmas and a Happy and Fruitful New Year. Jindřich (Henry) Kopeček Distinguished Professor and Chair (Back to the top)Collaboration with the National Cancer Institute Henry Kopeček with Drs. Y. Hallock and E. Tabibi co-organized the 2nd International Symposium on Tumor Targeted Delivery Systems held at NIH, Bethesda, Maryland, September 23-25, 2002. The Symposium was co-sponsored by the National Cancer Institute and the Controlled Release Society. About 140 leading scientists from all over the world discussed the present and future of novel methods of cancer treatment. (Back to the top)Utah International Symposium on Drug Delivery in March 2003 The Controlled Release Society Winter Symposium and the 11th International Symposium on Recent Advances in Drug Delivery Systems will be held March 3-6, 2003 in the Grand America Hotel in Salt Lake City. The Symposium is co-organized by J. Anderson, S. W. Kim, J. Kopeček, K. Park, and M. Davies. The meeting will bring together the leading academic and industrial scientists from North America, Europe, and Asia. The symposium will feature submitted and invited presentations, focusing on the advancement of drug delivery systems and future technology. The program will address the multidisciplinary needs of researchers working in the areas of pharmaceutics, polymer science, cell and molecular biology, and medicine. For more information please visit The Controlled Release Society. (Back to the top)We are grateful to all donors. Their generosity positively impacts our graduate program. The Watson Graduate Fellowships in Pharmaceutics and Pharmaceutical Chemistry is in its second year. We would like to recognize Dr. Charles Ebert, Senior Vice-President for his support. The ENZON Fellowships are in their third year. We applaud the support of Dr. Jeffery McGuire. The Novartis Fellowships are also in the third year. We appreciate the support of Dr. Yatindra Joshi. Dinesh and Kalpana Patel Fellowship We are grateful to Dr. Dinesh and Kalpana Patel for their continuing support. The Fellowship is in the fourth year. Thanks to continuous support from Pfizer we were able to establish the Pfizer Fellowship this year. We appreciate the support of Dr. Timothy A. Hagen. The Department is grateful to Dr. Kuramoto for the continuous support of the College of Pharmacy. Several times in the past years a graduate student from our Department was chosen as a fellowship recipient. (Back to the top)Thanks to a generous donation from Dr. Sung Wan Kim we have established the Distinguished Seminar Program. The first speaker (January 21, 2003) will be Dr. Milton Harris from Shearwater, Inc. Thanks to all alumni and friends individual donors. We really appreciate your support: Dr. Eric Mack Dr. Sandra Sims (matched by Pharmacia Corp.) (Back to the top)The following students joined our faculty in the Fall Semester of 2002: Chien-Wen “Jeff” Chang: Jeff graduated from National Cheng Kung University, Taiwan, in 1994 with a BS in Biology. In 1996 he graduated from National Tsing Hua University, Taiwan, with a MS in Radiation Biology. Jeff is the recipient of the Pfizer Fellowship. He is currently working in Dr. Zheng-Rong Lu’s lab. He enjoys watching movies, reading, basketball, and swimming. Han Chang Kang: Han graduated from Hanyang University, South Korea, in 1997 with a BS in Industrial Chemistry. He the graduated in 1999 with a degree in Materials Science & Engineering from Kwangju Institute of Science and Technology, South Korea. He is currently working in Dr. You Han Bae’s lab. He enjoys watching movies and surfing the Internet. Aaron Mohs: Aaron graduated in 2002 from St. John’s University with a BA in Chemistry. He is the recipient of the Enzon Fellowship and rotates through several labs. He enjoys playing golf, basketball, skiing, hiking, and traveling. Stephanie Mu: Stephanie graduated from the University of Utah in 2002 with a BS in Chemistry. She is the recipient of the Watson Fellowship and rotates through several labs. She enjoys shopping. Anagha Vaidya: Anagha graduated in 2001 from the University of Mumbai with a BS in Pharmaceutical Sciences. She is the recipient of the Patel Fellowship and rotates through several labs. She enjoys trekking and reading. Furong Ye: Furong graduated in 2001 from Fudan University with a BS in Polymer Materials & Engineering. She is currently working in Dr. You Han Bae’s lab. She enjoys music and the piano. Weiwei Zhu: Weiwei graduated in 2001 from Beijing Medical University with a degree in Pharmacy. She is currently working in Dr. Bruce Yu’s lab. She enjoys volleyball and tennis. Russell Johnson: Russell is a bioengineering student in the BS/MS program. He is currently working in Dr. Jindřich Kopeček’s lab. He enjoys backpacking, mountain biking, and hiking. (Back to the top)James Cavenaugh: James was a student of Dr. Jim Herron. James’ thesis is entitled, “Quantitative Studies in T and B Cell Epitope Mimicry.” Keith Jensen: Keith was a student of Dr. Jindřich Kopeček. Keith’s thesis is entitled, “The Internalization and Fate of HPMA Copolymer and Antisense-HPMA Copolymer Conjugates in Hep G2 Cells.” Aijun Tang: Aijun was a student of Dr. Jindřich Kopeček. Aijun’s thesis is entitled, “A Lymphocyte-targeting Polymeric Drug Delivery System Mediated by Receptor-binding Epitopes: Design, Synthesis and Characterizations.” Monica Tijerina: Monica was a student of Dr. Jindřich Kopeček. Monica’s thesis is entitled, “Evaluation of Cellular Responses to Photodynamic Therapy with HPMA Copolymer-Mce6 Conjugates in Human Ovarian Carcinoma Cells.” Kevin Warner: Kevin was a student of Dr. William Higuchi. Kevin’s thesis is entitled, “Mechanistic Aspects of Chemical Skin Permeation Enhancers.” (Back to the top)Undergraduate Summer Research Fellowship Program Bruce Yu, Ph.D. Assistant Professor 2002 is the 8th year of our department’s Undergraduate Summer Research Program. This year, we received 18 complete applications. With funding support from Prof. Higuchi and the chairman’s office, 9 were accepted into the program. Of the 9 students, 3 were from Utah, 5 from other states (New York, Idaho and North Carolina) and 1 from Egypt. All 9 students, working in 8 different labs, completed the program. The 10-week program ran from June 3rd to August 9th. A mid-term luncheon was held on July 1st to introduce the students to the larger community of the Department and to provide career consultation. A final oral/poster presentation session was held on August 8th with more than 30 attendees, including the summer trainees and graduate students, postdoctoral fellows as well as faculty members from the Department. The students reported their research results at the oral/poster session and in a written report. In addition to lab research, various enrichment activities, both professional and social, were organized for the students. Specifically, the students were given tours of the University of Utah Medical School (July 12th), the Huntsman Cancer Institute (July 12th) and the Watson Laboratories (July 15th). The purpose of these profession-oriented tours is to familiarize the students with local biomedical learning, teaching, research and working environment. This year, we also took active measures to provide information and consultation regarding career development to the trainees. At the mid-term luncheon, articles on career paths in biomedical research were distributed to the students. Considering the inter-disciplinary nature of pharmaceutical research and its close relationship with medicine, these articles can provide valuable information to the trainees and will help them to make informed career choices. Throughout the summer program, participating faculty members and senior graduate students also provided career-related advice to the trainees on an individual basis. For the first time, we requested feedback from trainees in the form of an exit questionnaire. All summer students filled out this questionnaire. Overall, the responses were very positive. The trainees commented that our program enhanced their understanding of the scientific research process and identified that the strongest aspect of our training program is lab techniques. All the trainees will recommend our program to fellow students at their home institutions. We are looking forward to making next year’s program more successful based on this year’s experience. Harshit Bakshi (Yu lab): “Synthesis of Di- and Tetra-peptide Fragments for the Study of Protein Based Polymers.” Jenny Blackham (Lim lab): “Subcellular Trafficking and Transcriptional Activity Studies of PR Isoforms.” Winter Chan (Kim lab): “Modified Linear PEI: Cholesterol Conjugates for Systemic Gene Delivery.” Brendan Gordon (Bae lab): “A Study of a Block Copolymer as a Potential Gene Therapy Agent.” Todd Kaneshiro (Lu lab): “The Synthesis of Macromolecular Biodegradable Contrast Agents for the MRI.” Sarah Molokhia (Higuchi lab): “Novel Approach to Quantifying Structure-Activity Relationship of Lipophilic Chemical Permeation Enhancers.” Sam Pevzner (Kern lab): “Variability in CSF Distribution of Drugs - Limitations of ‘Well Mixed’ Models.” Rachel Ross (Kim lab): “Biodegradable N,N-Dimethylhistidine-graft-Poly(L-lysine)-Poly(ethylene glycol) Multi-Block Copolymers for Hindlim Ischemia.” Stephen Tanner (Cheatham lab): “Drug-DNA binding: Modeling the Energetics of Minor Groove Binding by Furamidine Derivatives.” (Back to the top)The SAC is committed to working with the department’s faculty in order to foster a research environment that is conducive to learning but with an emphasis on developing a more “student friendly” environment for our graduate student body. To date the present committee has worked with the faculty in supporting the Summer Undergraduate Research Fellows. SAC entertained the students with a trip to the newly constructed Gateway Mall movie theatre that was followed by lunch. In addition, the committee took the students on hiking trips as well as to their final dinner after the poster presentations. The present SAC also worked in conjunction with last year’s SAC to support the Annual Department Picnic that was held at Sugarhouse Park. SAC arranged for the design and printing of the departmental T-shirts that were distributed at the picnic and helped in the serving of the food as well as clean-up after the picnic. In addition to this year’s picnic, the SAC prepared full RPT reports for non-tenured faculty for review by the Chair of the department. Presently, the SAC is involved in several projects such as student meetings, negotiating stipend increases and incentives for the graduate students for visits to their alma mater in order to promote the University as well as the Department for the purpose of increasing graduate student enrollment. The focus of our last graduate student meeting was to gain feedback on the new formats for the written and oral preliminary exams from the students who recently took the exams. In addition, the SAC presented a couple of ideas to the students with respect to the Annual Christmas Lunch catered by the Department. SAC is concerned with the rising cost of living in the Salt Lake area and is working with the Chair to determine whether or not stipend increases are warranted to not only keep up with the competitiveness of student recruitment but also to provide the present graduate students with a “reasonable” stipend. SAC realizes the value of recruitment and the difficulty in getting students to return to their alma mater in an effort to recruit new and excellent students to the department. Thus, SAC is presently in negotiations with the Chair of the Department in developing a program that provides some sort of incentive for the student as exchange for their diplomacy for student recruitment. This year SAC would like to contribute to the Annual Christmas Lunch in developing a Christmas Party as opposed to a Luncheon. We feel that this would foster a more open and friendly environment for both the students as well as the faculty. SAC also hopes to supplement the Party with a few games and raffles in order to add a little more enjoyment and fun for the graduate students as a show of appreciation for a hard working year in the department. In addition, the SAC is applying for funding by the AAPS Student Chapter as well as trying to increase AAPS membership among our students. In an effort to obtain more funding for student activities, SAC is also making inquiries as to becoming a registered “club” in order to qualify for funding by ASUU on campus. Finally, the SAC has planned tentative activities for the coming year such as assisting in the Annual College of Pharmacy Symposium, providing an activity for the students for the Spring semester – to be finalized in the next student meeting, assist the faculty in planning for new student recruitment for next year as well as for the Summer Undergraduate Research Fellows, assist in preparations for next year’s picnic, and hold elections for next year’s SAC. (Back to the top)GPEN Meeting in Ann Arbor, Michigan The Globalization of Pharmaceutical Education Network (GPEN) meeting took place in Ann Arbor. I really like the GPEN conferences. They are organized every two years; the last one was in Uppsala, Sweden. Only graduate students give lectures and present posters, they also chair sessions, etc. There is no other meeting where so many professors from pharmaceutics departments around the world listen to lectures of graduate students! Our Department was represented by seven students; Hui Ding delivered an oral presentation, David Day, Guang Yan, Chunyu Xu, Matt Fidler, Pad Chivukula, and Ram Goteti presented posters. Three students were supported by the Department and the GPEN organization, the others by their mentors. The selection process was organized by the Department SAC. The next meeting will take place in May 2004 in Kyoto, Japan. (Back to the top)The Alumni and Friends Breakfast took place during the Annual Association of Pharmaceutical Scientists Meeting in Toronto, Canada. It was a lot of fun meeting past friends and coworkers and remembering important moments from long ago. There were over 60 attendees, an excellent turnout. Drs. You Han Bae and Thomas Cheatham were formally introduced to the alumni – it was the first time they took part in the meeting as faculty in our department. Next year the AAPS meeting is in Salt Lake City, so we shall meet on home turf!
The next generation of Pharmaceutical Scientists at the 2002 AAPS Alumni and Friends Breakfast Harvey Jacobs. One of the hardest decisions I ever had to make was to leave Salt Lake City. Utah had been my home for over 20 years, the region where I earned my education, learned to play golf and ski, and the place where I raised my family. My social life was good in Utah, but I yearned for more in terms of academics and a career. I knew getting a tenure-track faculty position in the College of Pharmacy and being an independent researcher in the Department would be difficult. For these reasons, I looked elsewhere. I applied to several Schools of Pharmacy around the country and I was offered positions. I then discovered that my old alma mater, Wilkes University in Wilkes-Barre, Pennsylvania, was starting a Pharmacy program. Wilkes-Barre was my birthplace, and I still had many friends and family living in this area. Most of all, the thought of being one of the first faculty members of a program was exciting. I envisioned a graying, dusty picture of me 50 years later hanging in the halls. Through great detective work, I was able to track down the soon-to-be-named Dean and began the dialogue that lead to my being hired as the first full-time faculty member. Being hired was the easy part. The hard part was helping to put together the curriculum for a four-year Doctor of Pharmacy Program. We spent months reviewing the CAPE documents, establishing our outcomes and assessment tools, recruiting and interviewing faculty and students, and a thousand other tasks necessary to start a new program. We also had to plan, equip, and unpack equipment for one pharmaceutics dispensing lab and three research labs. On top of all this, I had to teach pharmaceutics! Out came Dr. Jack Cardinal’s notes (I am dating myself), along with cries of help to Dr. Jeff Fox and Dr. Kris Knutson for advice on syllabi and course content. Events were tracking into place in an ordered manner. We had students. We had faculty. We had a curriculum. We had labs. Most important, we had approval from ACPE to continue in our efforts. After the first few years of the program, a position as the Assistant Dean of the School of Pharmacy became vacant. I became the acting Dean on a temporary basis. I became responsible; enough said. The Assistant Dean is in charge of admitting students into the Pharmacy Program, awarding private scholarships to students, and enforcing the academic progression requirements in the School. This involves perhaps the hardest part of the job: advising students that they should seek another career. As the teaching and committee work eased, I began a basic research project. (As a note, Wilkes is a teaching intensive University with few graduate programs.) I had to recruit undergraduate students to perform research for class credits. As you can imagine, this was a drastic change from the research environment present in Utah. My first project was to study the controlled release of drugs from very simple biopolymers, such as starch and ligninn. I presented the results at several local meetings and at AAPS in 1998. Another project in which I am currently involved is investigating the binding properties of carbohydrates and antibodies to the bacteria causing gastric ulcers. Ultimately, I would like to prevent the binding and adherence of the bacteria to the GI lining and also target drugs directly to the site. The thrust behind this article was the question by Dr. Kopeček about “how your life has been since graduating, where your career has gone, and what is your research?” I hope you can tell from this narrative that everything is just fine. I truly believe that Dr. Sung Wan Kim, the Department of Pharmaceutics, and the University of Utah provided me with the academic and research skills necessary to succeed in my career. I will always be grateful. Hamid Ghandehari. I was doubly lucky to obtain both my BS in Pharmacy (1989) and PhD in Pharmaceutics and Pharmaceutical Chemistry (1991-1996) from the University of Utah in the beautiful foothills of Salt Lake City. After finishing my dissertation in the laboratory of Dr. Kopeček, I joined the faculty of the University of Mississippi School of Pharmacy as an Assistant Professor of Pharmaceutics. During the first year of my appointment at the University of Mississippi, with the support of my chairman and colleagues, I had the opportunity to take a short sabbatical to learn the techniques of genetic engineering of protein-based polymers at the Department of Molecular Biology of Protein Polymer Technologies in San Diego, California. These experiences helped me establish the three main areas of ongoing research in our laboratory. These include development of new polymers for drug delivery using genetic engineering techniques, exploring new applications for the existing chemically synthesized water-soluble polymeric carriers, and examining the structural factors that influence the transport of polymers across biological barriers. In July 1999 I moved to the University of Maryland School of Pharmacy, Department of Pharmaceutical Sciences where I am currently an Associate Professor. Wonderful and hard working graduate students in our lab, with tremendous advice from our collaborators, so far have shown: a) with strategic placement of amino acids in genetically engineered silkelastin-like block copolymers it is possible to control, in a precise fashion, the physicochemical properties of these polymers important for controlled drug and gene delivery, b) N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer – antileishmanial drug conjugates with appropriate side chains and targeting moieties are effective in the treatment of visceral leishmaniasis (a parasitic disease), and c) cationic dendrimers of appropriate size and concentration show appreciable oral bioavailability with limited toxicity. On the teaching front to professional PharmD students, having worked in the past as a full-time pharmacist in the greater Salt Lake valley for two years (1989-1991), I have tried to link the relevance of controlled drug delivery to pharmacy practice - in fact I have developed a new elective course entitled “Controlled Drug Delivery: Relevance to Pharmacy Practice”. It has been a great teaching experience. With the support of a wonderful family (my wife Mitra also a graduate of University of Utah - age undisclosed!, daughter Setareh - 19, and son Alborz - 14), great education and mentors in Utah, and the best graduate students in the world (OK I am just a little bit biased, but they are really good!), the long hours in academia seem short and enjoyable. Visit our website at: http://www.pharmacy.umaryland.edu/faculty/hghandeh/. Come visit us when you are in the Baltimore-Washington area. Although I can’t promise you the beauty and height of the mountains surrounding Salt Lake, indeed Fall colors in Western Maryland and Shenandoah Valley close to us are breathtaking! David Grainger received his Ph.D. from the Department of Pharmaceutical Chemistry at the University of Utah in 1987. He worked under Prof. Sung Wan Kim on a project that involved synthesis and testing of new polymers immobilized with anticoagulants to prevent blood clotting in surgical implants. These materials were eventually tested in the human artificial heart model under development in Utah at that time and were of interest to improve clinical performance of blood oxygenator and dialysis membranes, and blood-contacting catheters. After contemplating further pursuit of an M.D. degree at Utah, Grainger instead chose postdoctoral research work under Prof. Ringsdorf in Germany with support from a Humboldt postdoctoral fellowship.
Grainger pauses on his annual spring ascent and ski descent of the north face of Mt. Hood, Oregon (Mt. St. Helens, left, and Mt. Adams, right, in background). (photo credit: Jeff Schuh, Shutter-Up Enterprises).
Grainger at work in the general chemistry classroom where he enjoys the challenges of teaching large classes. (photo credit: Connie Young, Young Communiqué). Dr. Grainger's experience in Europe expanded his knowledge of surface chemistry in biological applications, particularly cell membrane surfaces and their interactions with proteins. After nearly two years in Germany, Grainger returned to become an assistant professor of chemistry at the Oregon Graduate Institute, the biomedical engineering arm of the Oregon Health Sciences University. There, funded by both private and public sources, he was able to rapidly develop a research group with projects focused on biomembrane models for biotechnology, and new polymer surfaces as improved biomaterials.He also developed a new interest in fluorinated surfaces similar to Dupont’s Teflon™. In 1994, he moved his family and research effort to Colorado State University’s Department of Chemistry as an Associate Professor. His research innovations in fluorinated surface chemistry attracted awards from Dupont and 3M. Grainger has also won several teaching awards for his pedagogical talent in large classroom science education and was promoted early to full professor at CSU in 1998. He has spent time overseas as an invited guest professor in Japan and France, working on molecular aspects of biomaterials response to human biology, including inflammation and rejection. A special leave-of-absence from CSU allowed Grainger several years ago to spend time in a biotechnology start-up company in Washington, D.C. for over a year. This intensive training experience brought Grainger desired expertise in formulating new protein drugs, including the increasingly popular lines of humanized antibodies entering clinical trials as new molecular entities (NMEs). He considers this a very valuable, formative experience in his ability to train students for technical jobs in industry. Grainger currently heads a group of 10 student researchers at CSU spread over chemistry, chemical engineering, microbiology and molecular biology. He is also helping to develop the campus’ biomedical engineering interdisciplinary graduate degree program. Nationally visible, Grainger has recently organized several major scientific symposia in the biomaterials area, including the internationally prominent Gordon Research Conference on Biomaterials and an NIH-sponsored Bioengineering Consortium meeting on biosensing. He currently serves on a National Institutes of Health review panel and editorial boards for several scientific journals, chairs a NASA advisory panel, and consults for several biotechnology companies. His research efforts have evolved to study the influence of biomaterials surfaces on cell signaling and bacterial adhesion, incorporating significant components of molecular and cell biology, and organismal physiology. Additionally, Grainger’s new research is focused on improving the technology of DNA and protein microarrays used for high-throughput advanced clinical assays and diagnostics. “My doctoral training with visionary, accomplished mentors at Utah set certain benchmarks for my career,” Grainger states. “I was always taught to seize opportunity. Given the rapid and interdisciplinary progress in biotechnology, it is difficult to keep up and know what’s important for the future. My broad training has optimized my ability to remain conversant with many aspects of medicine and biotechnology.” In his spare time, Dr. Grainger enjoys mountaineering, skiing and fly-fishing. Sandra M. Sims received her Ph.D. from the Department of Pharmaceutics, University of Utah in 1990. She worked with Dr. William I. Higuchi to examine the mechanism of transport of ions and small neutral molecules across skin during iontophoresis. After graduation, Dr. Sims chose a postdoctoral position at The Upjohn Company working with Dr. Norman F.H. Ho and his collaborators in Animal Health Parasitology Research. This project involved measuring and modeling the transport of ions across nematode cuticle and gave Dr. Sims the opportunity to pick worms from sheep stomach and to help introduce pharmaceutics into animal health research. “Working with Dr. Ho was tough but a lot of fun and we had a very productive 2 years together!” After completion of her postdoc in 1992, Dr. Sims chose to stay on at The Upjohn Company as a scientist in the Pharmaceutics Group. This was an exciting time as she was assigned to work with the Oxazolidinone discovery group providing physical chemical data for discovery compounds and formulation development for lead compounds. She had the great fortune to take one of these compounds (Zyvox) through discovery, formulation development, scale-up, regulatory filing, and market launch. Dr. Sims then spent two years as a project manager and group leader before accepting her current position of Associate Director for Animal Health Development in Global Pharmaceutical Sciences at Pharmacia Corporation (formerly Pharmacia & Upjohn). “It’s a joy to return to the U whenever I can and meet old and new faculty, meet the new students, and see the changes at the U and in the city.” Dr. Sims and her husband, Ben Maxey, are the proud (and exhausted) parents of two boys: Camden , age 5 years and Branden, age 2 years. Xiaoling Li. After their graduation from Dr. Kim’s group in 1991, the two University of Utah alumni, Xiaoling Li and Xinghang Ma, moved to the east coast with their one-year old son, Richard. Xiaoling pursued a post doctoral training at Ciba-Geigy (now part of Novartis) and Xinghang was employed by Emisphere as a research scientist. Two years later, the family made another move from New York, heading all the way across the country to California. Xiaoling took an assistant professor position at University of the Pacific, and Xinghang joined Cygnus and worked on development of transdermal drug delivery systems. Their second son, Louis, was born in 1994. Xinghang moved to Bayer Corp. in 1996, working in the area of freeze-drying and protein formulation. Xiaoling has been with the University of the Pacific since 1993. He was promoted to associate professor, and awarded tenure in 1999. His research focus in the past nine years has been in the areas of transbuccal drug delivery, novel polymers for pharmaceutical application, and targeting drug delivery. He has had a total of 59 presentations and publications after he joined the University of the Pacific. Five Ph.D. students have graduated under his direction. In 2000, he was appointed director of the Pharmaceutical and Chemical Sciences Graduate Program, a merged graduate program of the School of Pharmacy and the Department of Chemistry at the University of the Pacific. He started to serve as a chair of the Department of Pharmaceutics and Medicinal Chemistry in 2001. Between family and work, the couple is busy but content everyday. They enjoy every moment of their life in California, where they watch their sons grow and develop their careers, in addition to beautiful California sunshine. Whenever they have had any achievement in their career, they have always been grateful for being able to study under the superb supervision of Dr. Kim and feel that they are blessed by the fundamental training that they acquired in the Department of Pharmaceutics at the University of Utah. (Back to the top)Jindřich Kopeček was awarded the title of Distinguished Professor. Sung Wan Kim received the Volwiler Research Achievement Award from the American Association of Colleges of Pharmacy. Charu Kanwal - Walter F. Enz Award from the Pharmacia Corporation. Monica Tijerina – Jeffrey L. Fox Memorial Award Erica Wittwer – accepted to University of Utah Medical School. Erica will continue to pursue her Ph.D. degree. She is also the recipient of the Roy Kuramoto Fellowship. Chien-Wen “Jeff” Chang – Pfizer Fellowship. Aaron Mohs – Enzon Fellowship. Stephanie Mu – Watson Fellowship. Anagha Vaidya – Patel Fellowship. (Back to the top)NIH Grant DK56884; Bioactive Polymers for Effective Islet Delivery System, Y.-H. Bae, PI. NIH Grant HL32132; Multi-analyte Waveguide Immunosensing; J.N. Herron, PI. NIH Grant DE06569; Quantitation of Enamel Demineralization Mechanisms, W.I. Higuchi, PI. NIH Grant H/L65477; Functional and Targeting Polymeric Gene Carriers, S.W. Kim, PI. NIH Grant CA88047; Targeting to Lymphocytes Mediated by Synthetic Epitopes; J. Kopeček, PI. NIH Grant CA51578; A Polymeric Drug Delivery System for Cancer Therapy; J. Kopeček, PI. NIH Grant GM50839; Degradable Hydrogels for Oral Delivery of Calcitonin; J. Kopeček, PI. DOD Grant; Agonist-Occupied PRA Represses PRB via Interactions with Coactivators or Corepressors; C. Lim, PI. Pharmaceutical Research and Manufacturers of America (PhRMA) Foundation 2002 Research Starter Grant in Pharmaceutics; C. Lim, PI. PhRMA Foundation 2003 Research Starter Grant in Pharmaceutics; Y. B. Yu, PI. University of Utah Research Committee; Characterization of Pair Wise Interactions in Unfolded Polypeptide Chains; Y. B. Yu, PI. International Anesthesia Research Society Grant; Impact of Morphine Metabolites on Morphine Analgesia; S. Kern, P.-I. NSF Grant CHE-0218739; Multiscale Simulation of Biomolecular Assemblies on a Computational Grid, T. Cheatham, Co-P.-I. (Back to the top)Publications of our Faculty in 2002 You Han Bae S.Y, Chae, S.W. Kim, Y.H. Bae, “Bioactive Polymers for Biohybrid Artificial Pancreas,” J. Drug Targeting, 9(6), 473-484 (2001). B. Jeong, S.W. Kim, Y.H. Bae, “Thermosensitive Sol-gel Reversible Hydrogels,” Adv. Drug Del. Rev., 54, 37-51 (2002). J.H. Park, Y.H. Bae, “Hydrogels Based on Poly(ethylene oxide) and Poly(tetramethylene oxide) or Poly(dimethyl siloxane): Synthesis, Characterization and in vitro Protein and Platelet Adhesion,” Biomaterials, 23, 1797-1808 (2002). S.I Kang, Y.H. Bae, “pH-Induced Solubility Transition of Sulfonamide Based Polymers,” J. Control. Release, 80, 145-155 (2002). K. Na, Y.H. Bae, “ Self-assembled Hydrogel Nanoparticles Responsive to Tumor Extracellular pH from Pullulan Derivative/sulfonamide Conjugate: Characterization, Aggregation and Adriamycin Release in vitro,” Pharm. Res., 19, 681-688 (2002). C.H. Ahn, S.Y. Chae, Y.H. Bae, S.W. Kim, “Biodegradable Poly(ethyleneimine) for Plasmid DNA Delivery,” J. Control. Rel., 80, 273-282 (2002). S.Y. Chae, S.W. Kim, Y.H. Bae, “The Effect of Crosslinked Hemoglobin on Functionality and Viability of Microencapsulated Pancreatic Islets,” Tissue Eng., 8, 379-394 (2002). J.H. Park, Y.H. Bae, “Assessment of PEO/PTMO Multiblock Copolymer/segmented Polyurethane Blends as Coating Materials for Urinary Catheters: in vitro Bacterial Adhesion and Encrustation Behavior,” Biomaterials, 23, 3991-4000 (2002).H.C. Kang, Y.H. Bae, “Preparation and Characterization of New Immunoprotecting Membrane Coated with Amphiphilic Multiblock Copolymer,” Macromol. Res. (Korea),10, 67-74 (2002). J.H. Park, Y.H. Bae, “Physicochemical Properties and in vitro Biocompatibility of PEO/PTMO Multiblock Copolymer/segmented Polyurethane Blends,” J. Biomater. Sci. Polym. Ed., 13, 527-542 (2002). J.H. Park, Y.H. Bae, “Host Responses to Biomaterials,” Biomaterials Res. (Korea), 6(2), 53-64 (2002). Z. Zhong, P.J. Dijkstra, J. Feijen, Y.-Mi. Kwon, Y.H Bae, S.W. Kim, “Synthesis and Aqueous Phase Behavior of Thermoresponsive Biodegradable Poly(D,L-3-methyl glycolide)-b-poly(ethylene glycol)-b-poly(D,L-3-methyl glycolide) Triblock Copolymers,” Macromol. Chem. Phys., 203, 1797-1803 (2002). Thomas Cheatham F. Lankas, T. E. Cheatham, III, P. Hobza, J. Langowski, N. Spackova, J. Sponer, "Critical Effect of the N2 Amino Group on Structure, Dynamics and Elasticity of DNA Polypurine Tracts" Biophys. J., 82, 2592-2609 (2002). J. P. Lewis, J. Pikus, T. E. Cheatham, III, E. B. Starikov, H. Wang, J. Tomfohr, O. F. Sankey. "A Comparison of Electronic States in Periodic and Aperiodic poly(dA)-poly(dT) DNA." Phys. Stat. Sol. (b), 233, 90-100 (2002). James Herron A.-P. Wei, J. N. Herron, “Bifluorophoric Molecules as Fluorescent Beacons for Antibody-antigen Binding,” Journal Molecular Recognition, 15, 311-320 (2002). J.N. Herron, D. A. Christensen, K. D. Caldwell, V. Janatova, S.-C. Huang, H.-K. Wang (2002). “Apparatus for Multichannel Fluorescent Immunoassays.” U.S. Patent 6,340,598 (issued 1/22/02).
J.N. Herron, D. A. Christensen, V. A. Pollak, R. D. McEachern, E. M. Simon (2002). “Lens and Associatable Flow Cell.” U.S. Patent 6,356,676 (issued 3/12/02).
W.M. Reichert, J. N. Herron, D. A. Christensen, H.-K. Wang (2002). “Integrated Optic Waveguide Immunosensor.” U.S. Patent 6,350,413 (issued 2/26/02)
A.-P. Wei, J. N. Herron (2002). “Immunoassay Procedure Utilizing Fluorogenic Tracer Antigens.” U.S. Patent 6,482,655 (issued 11/19/2002). William Higuchi A.B. Barry, A.A. Baig, S.C. Miller, W.I. Higuchi, “Effect of Age on Rat Bone Solubility and Crystallinity,” Calcif. Tissue Int., 71, 67-171 (2002). Y. Song, S.K. Li, K.D. Peck, H. Zhu, A.H. Ghanem, W.I. Higuchi, “Human Epidermal Membrane Constant Conductance Iontophoresis: Alternating Current to Obtain Reproducible Enhanced Permeation and Reduced Lag Times of a Nonionic Polar Permeant,” Int. J. Pharm., 232, 45-57 (2002). H. Zhu, S.K. Li, K.D. Peck, D. Miller, W.I. Higuchi, “Improvements on Conventional Constant DC Iontophoresis: a Study Using Constant Conductance AC Iontophoresis,” J. Controlled Rel., 82, 249-261 (2002). C-L Liu, W.I. Higuchi, “Cholesterol Crystallite Nucleation in Supersaturated Model Biles from a Thermodynamic Standpoint,” Biochim. Biophys. Acta., 1588, 15-25 (2002). H. Zhuang, A.A. Baig, N. Zhang, A. Chhettry, W.I. Higuchi, “Relationships Involving Metastable Equilibrium Solubility, Surface Complexes, and Crystallite Disorder with Carbonated Apatites,” Calcif. Tissue Int., 69, 343-349 (2001). Steven Kern R.A. Lugo, S.E. Kern, “Clinical Pharmacokinetics of Morphine,” J Pain Palliative Care Pharmacotherapy, 16, 5-18 (2002). Sung Wan Kim W. Suh, S.-O. Han, L. Yu, S.W. Kim, “An Angiogenic, Endothelial-Cell-Targeted Polymeric Gene Carrier,” Molecular Therapy, 6, 664-672 (2002). Z. Zhong, P.J. Dijkstra, J. Feijen, Y.-M. Kwon, Y.H. Bae, S.W. Kim, “Synthesis and Aqueous Phase Behavior of Thermoresponsive Biodegradable Poly(D,L-3-methylglycolide)-Block-Poly(ethylene glycol)-Block-Poly(D,L-3-methyl glycolide) Triblock Copolymers,” Macromol. Chem. Phys., 203, 1797-1803 (2002). A. Maheshwari, S. Han, R.I. Mahato, S.W. Kim, “Biodegradable Polymer-Based Interleukin-12 Gene Delivery: Role of Induced Cytokines, Tumor Infiltrating Cells and Nitric Oxide in Anti-Tumor Activity,” Gene Therapy, 9, 1075-1084 (2002). S.Y. Chae, S.W. Kim, Y.H. Bae, “Effect of Cross-Linked Hemoglobin on Functionality and Viability of Microencapsulated Pancreatic Islets,” Tissue Engineering, 8, 379-394 (2002). M.S. Shim, H.T. Lee, W.S. Shim, I. Park, H. Lee, T. Chang, S.W. Kim, D.S. Lee, “Poly(D, L-lactic acid-co-glycolic acid)-b-poly(ethylene glycol)-b-Poly(D, L-lactic acid-co-glycolic acid) Triblock Copolymer and Thermoreversible Phase Transition in Water,” J. Biomed. Mater. Res., 61, 188-196 (2002). C.-H. Ahn, S.Y. Chae, Y.H. Bae, S.W. Kim, “Biodegradable poly(ethylenimine) for Plasmid DNA Delivery,” J. Control. Release, 80, 273-282 (2002). D.Y. Furgeson, R.N. Cohen, R.I. Mahato, S.W. Kim, “Novel Water Insoluble Lipoparticulates for Gene Delivery,” Pharmaceutical Res., 19, 382-390 (2002). M. Lee, J.J. Koh, S.-O. Han, K.S. Ko, S.W. Kim, “Prevention of Autoimmune Insulitis by Delivery of Interleukin-4 Plasmid Using a Soluble and Biodegradable Polymeric Carrier,” Pharmaceutical Res., 19, 246-249 (2002). J.M. Benns, R.I. Mahato, S.W. Kim, “Optimization of Factors Influencing the Transfection Efficiency of Folate-PEG-Folate-Graft-Polyethylenimine,” J. Control. Release, 79, 255-269 (2002). K. Sagara, S.W. Kim, “A New Synthesis of Galactose-Poly(ethyleneglycol)-Polyethylenimine for Gene Delivery to Hepatocytes,” J. Control. Release, 79, 271-281 (2002). J.-W. Nah, L. Yu, S.O. Han, C.-H. Ahn, S.W. Kim, “Artery Wall Binding Peptide-Poly(ethylene glycol)-Grafted-Poly(L-lysine)-based Gene Delivery to Artery Wall Cells,” J. Control. Release, 78, 273-284 (2002). S.Y, Chae, S.W. Kim, Y.H. Bae, “Bioactive Polymers for Biohybrid Artificial Pancreas,” J. Drug Targeting, 9(6), 473-484 (2001). B. Jeong, S.W. Kim, Y.H. Bae, “Thermosensitive Sol-gel Reversible Hydrogels,” Adv. Drug Del. Rev., 54, 37-51 (2002). Jindřich Kopeček A. Tang, J. Kopeček, “Presentations of Epitopes on Peptide Scaffolds and Selection of Lymphoma-Targeting Moieties Based on Epitope Recognition,” Biomacromolecules, 3, 421-431 (2002). D. Wang, M. Pechar, W. Li, P. Kopečková, D. Brömme, J. Kopeček, “Inhibition of Cathepsin K with Lysosomotropic Macromolecular Inhibitors,” Biochemistry, 41, 8849-8859 (2002). J. Kopeček, “Swell Gels,” Nature, 417, 388-391 (2002). M. Pechar, P. Kopečková, L. Joss, J. Kopeček, “Associative Diblock Copolymers of Poly(Ethylene Glycol) and Coiled Coil Peptides,” Macromol. Biosci., 2, 199-206 (2002). Y. Kasuya, Z.-R. Lu, P. Kopečková, S.E. Tabibi, J. Kopeček, “Influence of the Structure of Drug Moieties on the In Vitro Efficacy of HPMA Copolymer-Geldanamycin Derivative Conjugates,” Pharmaceutical Res., 19, 115-123 (2002). K.D. Jensen, P. Kopečková, J. Kopeček, “Antisense Oligonucleotides Delivered to the Lysosome Escape and Actively Inhibit the Hepatitis B Virus,” Bioconjugate Chem., 13, 975-984 (2002). T. Merdan, K. Kunath, D. Fischer, J. Kopeček, T. Kissel, “Intracellular Processing of Poly(ethyleneimine)/Ribozyme Complexes Can Be Observed in Living Cells Using Confocal Laser Scanning Microscopy and Inhibitor Experiments,” Pharmaceutical Res., 19, 140-146 (2002). Z.-R. Lu, J.-G. Shiah, S. Sakuma, P. Kopečková, J. Kopeček, “Design of Novel Bioconjugates for Targeted Drug Delivery,” J. Contr. Rel., 78, 165-173 (2002). K.D. Jensen, P. Kopečková, J.H.B. Bridge, J. Kopeček, “The Cytoplasmic Escape and Nuclear Accumulation of Endocytosed and Microinjected HPMA Copolymers and a Basic Kinetic Study in HepG2 Cells,” AAPS PharmSci, Volume 3, Issue 4, paper 32 (2002). http://www.aapspharmsci.org/scientificjournals/pharmsci/journal/01_32.html A. David, P. Kopečková, J. Kopeček, A. Rubinstein, “The Role of Galactose, Lactose and their Three-Dimensional Arrangement in the Biorecognition of HPMA Copolymers by Human Colon Adenocarcinoma Cells,” Pharmaceutical Res., 19, 1114-1122 (2002). Y. Luo, N.J. Bernshaw, Z.-R. Lu, J. Kopeček, G.D. Prestwich, “Targeted Delivery of HPMA Copolymer – Hyaluronan – Doxorubicin Bioconjugates,” Pharmaceutical Res., 19, 396-402 (2002). D. Wang, K. Dusek, P. Kopečková, M. Smrckova-Duskova, J. Kopeček, “Novel Aromatic Azo-Containing pH-Sensitive Hydrogels: Synthesis and Characterization,” Macromolecules, 35, 7791-7803 (2002). C. Konak, B. Ganchev, M. Teodorescu, K. Matyjaszewski, P. Kopečková, J. Kopeček, “Poly[N-(2-Hydroxypropyl)methacrylamide-block-n-Butyl Acrylate] Micelles in Water/DMF Mixed Solvents,” Polymer, 43, 3735-3741 (2002). S. Sakuma, Z.-R. Lu, B. Pecharova, P. Kopečková, J. Kopeček, “N-(2-Hydroxypropyl)methacrylamide Copolymer – 9-Aminocamptothecin Conjugate: Colon-Specific Delivery in Rats,” J. Bioact. Comp. Polym., 17, 305-319 (2002). T. Merdan, J. Kopeček, T. Kissel, “Prospects for Cationic Polymers in Gene and Oligonucleotide Therapy against Cancer,” Adv. Drug Delivery Rev., 54, 715-758 (2002). C. Xu, L. Joss, C. Wang, M. Pechar, J. Kopeček “The Influence of Fusion Sequence on the Thermal Stabilities of Coiled-Coil Proteins” Macromol. Biosci., 2, 395-401 (2002). Carol Lim C. Kanwal, H. Li, and C. S. Lim, “Model
System to Study Classical Nuclear Export Signals,” AAPS
Pharm. Sci., 4(3), 18
(2002).
(http://www.aapspharmsci.org/scientificjournals/pharmsci/journal/ps040318.htm)
Zheng-Rong Lu Y. Kasuya, Z.-R. Lu, P. Kopečková, S. E. Tabibi, J. Kopeček, “Influence of the Structure of Drug Moieties on the in vitro Efficacy of HPMA Copolymer-geldanamycin Derivative Conjugates,” Pharm. Res., 19, 115-123, (2002).
Bruce Yu Yu, Y.B., “Coiled-coils: Stability, Specificity, and Drug Delivery Potentials,” Adv. Drug Delivery Rev. 54, 1113-1129 (2002). (Back to the top)You Han Bae You Han was an invited speaker at the 7th European Symposium on Controlled Drug Delivery, Noordwijk, ann Zee in The Netherlands in April and he traveled to Taipei, Taiwan in the same month to present an invited lecture at the 3rd Asian International Symposium on Polymeric Biomaterials Science and Drug Delivery. You Han visited the Department of Pharmaceutics, University of Minnesota to deliver a seminar in June and to NaPro BioTherapeutics, a company located in Boulder, CO to give a seminar in July. He traveled to Washington D.C. for review of NIH SBIR proposals between June and July. In July, You Han made a trip to Korea for multiple purposes: to visit Kwangju Inst. Sci. & Tech (K-JIST) to see and discuss with his K-JIST students, to visit Seoul National University for a seminar and to attend the 29th CRS meeting with various activities (session chair, JCR editorial board meeting, Board of Scientific Advisor meeting, best paper pick up). In August You Han traveled to D.C. for a NIH NIDDK proposal review meeting. For the third visit D.C. in 2002, You Han presented a paper at the 2nd International Symposium on Tumor Targeted Delivery Systems, Rockville, MD in September. In between October and November he visited Korea to present seminars at Boryong Pharm. Co. and SungKyunKwan University and to deliver an invited talk at the 11th Functional Polymer Materials Workshop on Nanobiomaterials for drug, gene and cell therapy, Daejeon. You Han attended AAPS meeting in November, Toronto, Canada for Pharm. Res. editorial board meeting and presentation of 4 papers. In December You Han will make the last trip in this year to Kobe, Japan to present a keynote lecture at the 5th International Meeting of the Tissue Engineering Society International in conjunction with the Japanese Society for Tissue Engineering and to Kwangju, Korea to attend defense presentations of his K-JIST master students, and to attend a symposium at Maui to celebrate Prof. Allan Hoffman accomplishments where he will present an invited talk. Thomas Cheatham In addition to quarterly travel to various locals to serve on the Alliance Allocations Board and National Resource Allocations Committee review panels for large grants of computer time at the national computer centers, Cheatham has been moderately busy with travel this year. Starting on a somber, but also celebratory note, he helped organize and spoke at the Biophysical Society/UCSF sponsored Peter Kollman Memorial Symposia in San Francisco in March. Next came travel to New England for an AMBER developers force field meeting and the Computational Chemistry Gordon conference in early July. Back to Boston in August for an invited talk at the American Chemical Societies National Meeting, most recently he traveled to the University of Michigan to give a Pfizer Seminar in Medicinal Chemistry. James Herron In Janaury 2002, Prof. Herron attended BiOS 2002, the annual meeting of the Biomedical Optics Society. At the meeting, he was the co-chair of a conference entitled “Clinical Diagnostic Systems: Technologies and Instrumentation” and chaired a podium session entitled “Diagnostic Sensor Technologies.” In June 2002, Prof. Herron attended the 5th International Weber Symposium on Innovative Fluorescence Methodologies in Biochemistry and Medicine in Lihue, Hawaii (on the island of Kaua'i). At the meeting he chaired a session and presented a poster entitled “Single Chain Polymorphism Analysis in Long Qt Syndrome using Planar Waveguide Fluorescent Biosensors”. Prof. Herron also organized and presided over two semiannual meetings of the Center for Biopolymers at Interfaces held in May and October 2002, and also entertained two visiting scientists from Sweden—Dr. Ove Öhman, Åmic AB, Uppsala and Prof. Fredrik Nikolajeff, Uppsala University. William Higuchi In March, 2002 Dr. William Higuchi attended the International/American Association of Dental Research. In November, 2002, Dr. Higuchi presented an invited lecture in a symposium on Dermal and Transdermal Drug Delivery in Ann Arbor, Michigan. From there he continued on to Toronto for the AAPS Annual Meeting. Steven Kern In May, I traveled to Philadelphia to visit Drexel University Department of Bioengineering where I worked with Dr. Dov Jaron on an upcoming special issue of the Engineering in Medicine and Biology Magazine. During the visit, I attended a minor league baseball game with my dad where I was chosen to through out the first pitch. (see picture from the local newspaper below) As is evident from my form, I should not give up my day job with dreams of becoming a professional baseball player. I was an invited lecturer in Caracas Venezuela this past summer where I gave two lectures at the University of Central Venezuela, Caracas, Venezuela on Closed loop drug delivery for anesthetic and analgesic agents and Cone snails as sources of pharmacologic agents. I spent four days in Caracas with my student Olinto Linares who was a tremendous host in Venezuela. In the Fall, I was an invited participant at the International working symposium on Pain and Analgesia: a cross species approach, sponsored by the Mayday Fund. This was held in Warrenton VA in September 2002.
Dr. Steven Kern—baseball’s MVP. Sung Wan Kim During 2002, Sung Wan Kim presented numerous interesting lectures at prestigious meetings throughout the world. This is a highlight of those travels. In April, at the 7th European Symposium on Drug Delivery, Netherlands, Sung Wan presented Intratumoral Delivery of P2CMVmIL-12 Gene Using Water Soluble Lipopolymers. At the Annual Controlled Release Society Meeting, July, Seoul, Korea, Sung Wan presented a plenary lecture entitled Gene Delivery: From Uncertainty to Reality. Moreover, Sung Wan traveled to Kansas City where he received the 2002 Volwiler Research Achievement Award at the annual meeting of the American Association of Colleges of Pharmacy (AACP), where he addressed Pharmaceutical Approach For Gene Therapy. This award recognizes outstanding research achievement by an AACP pharmacy educator. October found Sung Wan in Boston at the ACS Prospectives Conference discussing VEGF Gene Delivery for the Treatment of Ischemic Myocardium; and, later that month he presented Nanobiomaterials for Drug Delivery at the Korea Advanced Institute of Science and Technology. New Biodegradable Polymers for Delivery of Bioactive Agents was Sung Wan's topic at the IUPAC conference in Kyoto, Japan, early December. Sung Wan will join Henry Kopeček, among other distinguished colleagues, to honor Professor Allan Hoffman, at the UWEB Symposium, in Maui, Hawaii, and will continue his stimulating lectures on local gene delivery with polymer carrier. Jindřich (Henry) Kopeček Henry traveled to Ventura, California in February where he was Vice-Chair of the Gordon Conference on “Drug Carriers in Medicine and Biology”. In March Henry gave lectures at the University of Maryland in Baltimore and at the University of Alabama in Huntsville. In April he presented an invited lecture at the 7th European Symposium on Drug Delivery in Noordwijk aan Zee in The Netherlands. In June Henry lectured at the Cancer Institute of the University of California in San Diego, followed by an invited lecture at the International Conference in Advances in Biomaterials for Reconstructive Medicine, in Capri, Italy. In July Henry was invited speaker at the World Polymer Congress IUPAC MACRO 2002, Beijing, China, and at the 29th International Symposium on Controlled Release of Bioactive Materials, in Seoul, Korea. In September, Henry co-organized the 2nd International Symposium on Tumor Targeted Delivery Systems in Bethesda (see special report) and was invited to lecture at the 11th International Pharmaceutical Technology Symposium “Intelligent Drug Delivery Systems“, in Istanbul, Turkey. After the meeting Henry and Pavla spent three days in Asia Minor and visited numerous Greek and Roman historical sites. One of the most impressive places was the town of Ephesus. A library built in the 2nd century is shown in the picture below. In October Henry lectured at the American Chemical Society Conference “Future Directions in Drug Delivery Technologies“ in Boston, Massachussetts. In November Henry traveled with department students to the GPEN Conference in Ann Arbor, Michigan (see special report) and to the AAPS Meeting in Toronto, Canada. In December Henry will lecture at the Symposium honoring Prof. A. Hoffman’s 70th birthday in Maui, Hawaii.
Library in Ephesus, Turkey built about 1,850 years ago. Zheng-Rong Lu Zheng-Rong traveled to San Francisco, California in April where he presented at the Annual Meeting of American Association for Cancer Research. In August Zheng-Rong presented his work on novel magnetic resonance imaging contrast agents at the First Annual Meeting of Molecular Imaging in Boston, Massachusetts. Bruce Yu Bruce Yu attended the Western Biocalorimetry Conference held on Sep. 20th, 2002 at San Francisco State University as an invited speaker. The title of his talk was "Contribution of Translational and Rotational Motions to Molecular Association in Aqueous Solution". From Nov. 18th to 22nd, Bruce Yu traveled to
Baltimore to carry out some collaborative work at the Johns Hopkins
University. He was also invited by the Department of Pharmaceutical
Sciences of the University of Maryland for a visit and gave a
presentation entitled, "Contribution of Translational and
Rotational Motions to Molecular Association in Aqueous Solution".
He also visited the University of Maryland Institute of
Biotechnology and discussed potential collaborations. Carol Lim In October Carol Lim traveled to Washington, DC
to attend a conference sponsored by the Laboratory of Receptor
Biology and Gene Expression, NCI, NIH: "From DNA to Chromatin to
Cell Biology." She presented a seminar titled "Drug-Receptor
Trafficking: Import Kinetics and Export Mechanisms." ANNUAL GIVING As Dr. Kopeček indicated in his message, your financial support is greatly needed if we are going to continue to attract outstanding graduate students and further increase the level of scientific excellence. We hope that you can respond generously. YOUR CONTRIBUTION IS VITAL! SEND TO: INDICATE: Department of Pharmaceutics and Pharmaceutical Chemistry MATCH: Many companies match employees contributions (Back to the top) |
