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<v:path o:extrusionok="f" gradientshapeok="t" o:connecttype="rect"/> <o:lock v:ext="edit" aspectratio="t"/> </v:shapetype><v:shape id="Picture_x0020_2" o:spid="_x0000_s1027" type="#_x0000_t75" alt="Health Science Center" style='position:absolute;margin-left:101pt; margin-top:0;width:141pt;height:25.5pt;z-index:251657728;visibility:visible; mso-wrap-distance-left:0;mso-wrap-distance-right:0; mso-position-horizontal:right;mso-position-horizontal-relative:text; mso-position-vertical-relative:line' o:allowoverlap="f"> <v:imagedata src="http://www.pharmacy.utah.edu/pharmaceutics/images/hsc.jpg"/> <w:wrap type="square" anchory="line"/> </v:shape><![endif]--><![if !vml]><img width=188 height=34 src="http://www.pharmacy.utah.edu/pharmaceutics/images/hsc.jpg" align=right alt="Health Science Center" v:shapes="Picture_x0020_2"><![endif]></p> </td> <td width="70" style='background:white;padding:0in 11.25pt 0in 0in'> <p class=MsoNormal align=right style='margin:0in;margin-bottom:.0001pt; text-align:right'><b><span style='font-size:13.0pt;font-family:"Verdana","sans-serif"; color:#996666'>&nbsp;<o:p></o:p></span></b></p> </td> </tr> <tr style='mso-yfti-irow:1;height:3.0pt'> <td colspan=3 style='background:#993333;padding:0in 11.25pt 1.5pt 0in; height:3.0pt'> <p class=MsoNormal align=right style='margin:0in;margin-bottom:.0001pt; text-align:right;mso-line-height-alt:3.0pt'><span style='color:white'>| <a href="file:///C:\pharmaceutics\index.html"><b><span style='font-size:9.5pt; font-family:"Arial","sans-serif";color:white'>Home Page</span></b></a> | <a href="http://www.pharmacy.utah.edu/"><b><span style='font-size:9.5pt; font-family:"Arial","sans-serif";color:white'>College of Pharmacy</span></b></a> <o:p></o:p></span></p> </td> </tr> <tr style='mso-yfti-irow:2;mso-yfti-lastrow:yes'> <td colspan=3 style='background:#CCCCCC;padding:0in 0in 0in 0in'> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><strong><span style='font-size:11.5pt;font-family:"Verdana","sans-serif";color:#993333'><a href="file:///C:\pharmaceutics\facilities.html"><span style='font-family: "Arial","sans-serif"'>&nbsp;&nbsp;Facilities</span></a>&nbsp;/&nbsp; </span><span style='font-size:11.5pt;font-family:"Arial","sans-serif";color:#993333'>&nbsp;&nbsp;<a href="http://www.pharmacy.utah.edu/pharmaceutics/contacts/index.cfm?fuseaction=main.showGroups">Research <span style='font-size:12.0pt'>Groups</span><span style='font-family: "Verdana","sans-serif";mso-bidi-font-family:"Times New Roman"'>&nbsp;</span></a></span><span style='font-size:11.5pt;font-family:"Verdana","sans-serif";color:#993333'>/&nbsp; <a href="file:///C:\pharmaceutics\publications\"><span style='font-family: "Arial","sans-serif"'>Publications</span></a>&nbsp;/&nbsp; <a href="../cccd.html"><span style='font-family:"Arial","sans-serif"'>CCCD</span></a> </span></strong><span style='font-size:11.5pt;font-family:"Verdana","sans-serif"; color:#993333'><o:p></o:p></span></p> </td> </tr> </table> </div> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><span lang=EN style='display:none;mso-hide:all;mso-ansi-language:EN'><o:p>&nbsp;</o:p></span></p> <div align=center> <table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=843 style='width:579.0pt;mso-cellspacing:0in;mso-yfti-tbllook:843;mso-padding-alt: 0in 0in 0in 0in'> <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes;mso-yfti-lastrow:yes'> <td width="22%" valign=top style='width:22.0%;border:none;border-right:solid #993333 1.0pt; mso-border-right-alt:solid #993333 .75pt;background:#EEF0F0;padding:0in 11.25pt 0in 11.25pt'> <div style='margin-top:7.5pt;margin-bottom:3.0pt'> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><span style='font-size:9.5pt;font-family:"Arial","sans-serif"'><a href="file:///C:\pharmaceutics\statistics.html"><b>Department Profile</b></a> <o:p></o:p></span></p> </div> <div style='margin-top:7.5pt;margin-bottom:3.0pt'> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><span style='font-size:9.5pt;font-family:"Arial","sans-serif"'><a href="file:///C:\pharmaceutics\message.html"><b>Department Chair Message</b></a> <o:p></o:p></span></p> </div> <div style='margin-top:7.5pt;margin-bottom:3.0pt'> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><span style='font-size:9.5pt;font-family:"Arial","sans-serif"'><a href="file:///C:\pharmaceutics\admission.html"><b>Admission</b></a> <span class=menulinks3><a href="file:///C:\pharmaceutics\admission.html"><b>Admission</b></a></span><span style='display:none;mso-hide:all'><br> <span class=menulinks3><a href="file:///C:\pharmaceutics\gradAdmission.html"><b>Graduate School Information</b></a></span><br> <span class=menulinks3><a href="file:///C:\pharmaceutics\surfAdmission.html"><b>Summer Undergraduate Information</b></a></span><br> <span class=menulinks3><a href="http://www.utah.edu/graduate_school/why_utah/"><b>Why Utah?</b></a> </span></span><o:p></o:p></span></p> </div> <div style='margin-top:7.5pt;margin-bottom:3.0pt'> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><span style='font-size:9.5pt;font-family:"Arial","sans-serif"'><a href="file:///C:\pharmaceutics\facilities.html"><b>Research</b></a> <span class=menulinks3><a href="file:///C:\pharmaceutics\facilities.html"><b>Facilities</b></a></span><span style='display:none;mso-hide:all'><br> <span class=menulinks3><a href="file:///C:\pharmaceutics\cccd.html"><b>CCCD</b></a></span><br> <span class=menulinks3><a href="file:///C:\pharmaceutics\publications"><b>Publications</b></a></span><br> <span class=menulinks3><a href="file:///C:\pharmaceutics\contacts\index.cfm%3ffuseaction=main.showGroups"><b>Research Groups</b></a></span></span><o:p></o:p></span></p> </div> <div style='margin-top:7.5pt;margin-bottom:3.0pt'> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><span style='font-size:9.5pt;font-family:"Arial","sans-serif"'><a href="file:///C:\pharmaceutics\calendar.cfm"><b>Calendar</b></a> <o:p></o:p></span></p> </div> <div style='margin-top:7.5pt;margin-bottom:3.0pt'> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><span style='font-size:9.5pt;font-family:"Arial","sans-serif"'><a href="file:///C:\pharmaceutics\aboutUs.html"><b>About Us</b></a> <span class=menulinks3><a href="file:///C:\pharmaceutics\aboutUs.html"><b>About Us</b></a></span><span style='display:none;mso-hide:all'><br> <span class=menulinks3><a href="file:///C:\pharmaceutics\about.html"><b>About Pharmaceutics</b></a></span><br> <span class=menulinks3><a href="file:///C:\pharmaceutics\career.html"><b>Pharmacy Career Information</b></a></span><br> <span class=menulinks3><a href="file:///C:\pharmaceutics\history.html"><b>Department History</b></a> </span></span><o:p></o:p></span></p> </div> <div style='margin-top:7.5pt;margin-bottom:3.0pt'> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><span style='font-size:9.5pt;font-family:"Arial","sans-serif"'><a href="file:///C:\pharmaceutics\student_info\prelim.html"><b>Graduate Student Information</b></a> <span class=menulinks3><a href="file:///C:\pharmaceutics\student_info\prelim.html"><b>Preliminary Exams</b></a></span><span style='display:none;mso-hide:all'><br> <span class=menulinks3><a href="file:///C:\pharmaceutics\student_info\seminars.html"><b>Seminars</b></a></span><br> <span class=menulinks3><a href="file:///C:\pharmaceutics\student_info\coursework.html"><b>Course Work</b></a></span><br> <span class=menulinks3><a href="file:///C:\pharmaceutics\student_info\gradforms.html"><b>Graduate Forms</b></a></span><br> <span class=menulinks3><a href="file:///C:\pharmaceutics\student_info\faq.html"><b>FAQs</b></a></span><br> <span class=menulinks3><a href="file:///C:\pharmaceutics\student_info\aaps.html"><b>AAPS</b></a></span><br> <span class=menulinks3><a href="http://www.utah.edu/graduate_school/why_utah/"><b>Why Utah?</b></a> </span></span><o:p></o:p></span></p> </div> <div style='margin-top:7.5pt;margin-bottom:3.0pt'> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><span style='font-size:9.5pt;font-family:"Arial","sans-serif"'><a href="file:///C:\pharmaceutics\contacts"><b>Contact Information/<br> Directories</b></a> <span class=menulinks3><a href="file:///C:\pharmaceutics\contacts"><b>Main Contacts</b></a></span><span style='display:none;mso-hide:all'><br> <span class=menulinks3><a href="file:///C:\pharmaceutics\contacts\index.cfm%3ffuseaction=main.show_Directory&amp;usertype=1&amp;tab=2"><b>Faculty Directory</b></a></span><br> <span class=menulinks3><a href="file:///C:\pharmaceutics\contacts\index.cfm%3ffuseaction=main.show_Directory&amp;usertype=3&amp;tab=2,3"><b>Staff Directory</b></a></span><br> <span class=menulinks3><a href="file:///C:\pharmaceutics\contacts\index.cfm%3ffuseaction=main.show_Directory&amp;usertype=2&amp;tab=2,2"><b>Research Faculty</b></a></span><br> <span class=menulinks3><a href="file:///C:\pharmaceutics\contacts\index.cfm%3ffuseaction=main.show_Directory&amp;usertype=4&amp;tab=2,4"><b>Students - Pharmaceutics</b></a></span><br> <span class=menulinks3><a href="file:///C:\pharmaceutics\contacts\index.cfm%3ffuseaction=main.show_Directory&amp;usertype=5&amp;tab=2,5"><b>Students - Other Departments</b></a></span><br> <span class=menulinks3><a href="file:///C:\pharmaceutics\contacts\index.cfm%3ffuseaction=main.show_Directory&amp;usertype=6&amp;tab=2,6"><b>Research Associates</b></a></span><br> <span class=menulinks3><a href="file:///C:\pharmaceutics\contacts\index.cfm%3ffuseaction=main.showFullDirectory&amp;tab=3"><b>Full Directory</b></a> </span></span><o:p></o:p></span></p> </div> <div class="MsoNormal" style='margin-top:7.5pt;margin-bottom:3.0pt'> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><span style='font-size:9.5pt;font-family:"Arial","sans-serif"'><a href="file:///C:\pharmaceutics\news"><b>Newsletters</b></a> <span class=menulinks3><a href="file:///C:\pharmaceutics\news\2006.html"><b>2006</b></a></span><span style='display:none;mso-hide:all'><br> <span class=menulinks3><a href="file:///C:\pharmaceutics\news\2005.html"><b>2005</b></a></span><br> <span class=menulinks3><a href="file:///C:\pharmaceutics\news\2004.html"><b>2004</b></a></span><br> <span class=menulinks3><a href="file:///C:\pharmaceutics\news\2003.html"><b>2003</b></a></span><br> <span class=menulinks3><a href="file:///C:\pharmaceutics\news\2002.html"><b>2002</b></a></span><br> <span class=menulinks3><a href="file:///C:\pharmaceutics\news\2001.html"><b>2001</b></a></span><br> <span class=menulinks3><a href="file:///C:\pharmaceutics\news\2000.html"><b>2000</b></a></span><br> <span class=menulinks3><a href="file:///C:\pharmaceutics\news\1999.html"><b>1999</b></a></span></span><o:p></o:p></span></p> </div> <div style='margin-top:7.5pt;margin-bottom:3.0pt'> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><span style='font-size:9.5pt;font-family:"Arial","sans-serif"'><a href="file:///C:\pharmaceutics\gpen.html"><b>GPEN</b></a> <o:p></o:p></span></p> </div> <div style='margin-top:7.5pt;margin-bottom:3.0pt'> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><span style='font-size:9.5pt;font-family:"Arial","sans-serif"'><a href="file:///C:\pharmaceutics\courses.html"><b>Course List</b></a> <o:p></o:p></span></p> </div> <div style='margin-top:7.5pt;margin-bottom:3.0pt'> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><span style='font-size:9.5pt;font-family:"Arial","sans-serif"'><a href="file:///C:\pharmaceutics\handouts.html"><b>Handouts</b></a> <o:p></o:p></span></p> </div> <div style='margin-top:7.5pt;margin-bottom:3.0pt'> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><span style='font-size:9.5pt;font-family:"Arial","sans-serif";mso-no-proof:yes'><img border=0 width=40 height=15 id="_x0000_i1028" src="http://www.pharmacy.utah.edu/pharmaceutics/images/starry.gif" alt="http://www.pharmacy.utah.edu/pharmaceutics/images/starry.gif"></span><span style='font-size:9.5pt;font-family:"Arial","sans-serif"'><a href="file:///C:\pharmaceutics\news.html"><b>Recent News</b></a> </span><span style='font-size:9.5pt;font-family:"Arial","sans-serif";mso-no-proof:yes'><img border=0 width=40 height=15 id="_x0000_i1029" src="http://www.pharmacy.utah.edu/pharmaceutics/images/starry.gif" alt="http://www.pharmacy.utah.edu/pharmaceutics/images/starry.gif"></span><span style='font-size:9.5pt;font-family:"Arial","sans-serif"'><o:p></o:p></span></p> </div> <p class=MsoNormal style='margin-top:0in;margin-right:0in;margin-bottom:12.0pt; margin-left:0in'><span style='font-size:9.5pt;font-family:"Arial","sans-serif"'><o:p>&nbsp;</o:p></span></p> <div class=MsoNormal align=center style='margin:0in;margin-bottom:.0001pt; text-align:center'><span style='font-size:9.5pt;font-family:"Arial","sans-serif"'> <hr size=2 width="100%" noshade style='color:#993333' align=center> </span></div> <div> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><span style='font-size:9.5pt;font-family:"Arial","sans-serif";color:#666666'>Department of Pharmaceutics &amp; Pharmaceutical Chemistry<br> College of Pharmacy<br> 301 Skaggs Hall<br> 30 South 2000 East<br> Salt Lake City, UT 84112<br> phone: (801) 581-7831<br> fax: (801) 581-3674 <o:p></o:p></span></p> </div> <p class=MsoNormal style='margin-top:0in;margin-right:0in;margin-bottom:12.0pt; margin-left:0in'><span style='font-size:9.5pt;font-family:"Arial","sans-serif"'><br> <br> <br style='mso-special-character:line-break'> <![if !supportLineBreakNewLine]><br style='mso-special-character:line-break'> <![endif]><o:p></o:p></span></p> </td> <td valign=top style='background:white;padding:0in 3.75pt 0in 3.75pt'> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><o:p>&nbsp;</o:p></p> <p class=texttitle2>The Department of Pharmaceutics &amp; Pharmaceutical Chemistry<o:p></o:p></p> <div style='mso-element:para-border-div;border:solid black 1.0pt;mso-border-top-alt: .75pt;mso-border-left-alt:.25pt;mso-border-bottom-alt:.75pt;mso-border-right-alt: .25pt;mso-border-color-alt:black;mso-border-style-alt:solid;padding:2.0pt 4.0pt 2.0pt 4.0pt; background:#BB5555'> <p class=sectiontitle>Publications </div> <p class=rheaderred>Contents:<o:p></o:p></p> <ul type=disc> <li class=MsoNormal style='color:black;mso-list:l2 level1 lfo1;tab-stops: list .5in;background:whitesmoke'><a href="#A2008Publications1"><b>2008 Publications</b></a> <o:p></o:p> </li> <ul type=circle> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#YouHanBae8"><b>You Han Bae</b></a> <o:p></o:p> </li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#ThomasCheatham8"><b>Thomas Cheatham</b></a> <o:p></o:p> </li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#DavidGrainger8"><b>David Grainger</b></a> <o:p></o:p> </li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#HamidGhandehari8"><b>Hamid Ghandehari</b></a> <o:p></o:p> </li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#JamesHerron8"><b>James Herron</b></a> <o:p></o:p> </li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#WilliamHiguchi8"><b>William Higuchi</b></a> <o:p></o:p> </li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#SungWanKim8"><b>Sung Wan Kim</b></a> <o:p></o:p> </li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#JindrichKopecek8"><b>Jindrich Kopecek</b></a> <o:p></o:p> </li> <li class=MsoNormal style='color:#632423;mso-list:l2 level2 lfo1; tab-stops:list 1.0in;background:whitesmoke'><a href="#ZhengRongLu8"><b><span style='color:#632423'>Zheng-Rong Lu</span></b></a> <o:p></o:p> </li> </ul> <ul type=disc> <li class=MsoNormal style='color:black;mso-list:l2 level1 lfo1;tab-stops: list .5in;background:whitesmoke'><a href="#A2007Publications1"><b>2007 Publications</b></a><o:p></o:p></li> <ul type=circle> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#YouHanBae7"><b>You Han Bae</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#ThomasCheatham7"><b>Thomas Cheatham</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#DavidGrainger7"><b>David Grainger</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#HamidGhandehari7"><b>Hamid Ghandehari</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#JamesHerron7"><b>James Herron</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#WilliamHiguchi7"><b>William Higuchi</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#StevenKern7"><b>Steven Kern</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#SungWanKim7"><b>Sung Wan Kim</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#JindrichKopecek7"><b>Jindrich Kopecek</b></a> <o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#CarolLim7"><b>Carol Lim</b></a><o:p></o:p></li> <li class=MsoNormal style='color:#632423;mso-list:l2 level2 lfo1; tab-stops:list 1.0in;background:whitesmoke'><a href="#ZhengRongLu7"><b><span style='color:#632423'>Zheng-Rong Lu</span></b></a><o:p></o:p></li> </ul> <li class=MsoNormal style='color:black;mso-list:l2 level1 lfo1;tab-stops: list .5in;background:whitesmoke'><a href="#2006Publications1"><b>2006 Publications</b></a><o:p></o:p></li> <ul type=circle> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#YouHanBae6"><b>You Han Bae</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#ThomasCheatham6"><b>Thomas Cheatham</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#DavidGrainger6"><b>David Grainger</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#JamesHerron6"><b>James Herron</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#WilliamHiguchi6"><b>William Higuchi</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#StevenKern6"><b>Steven Kern</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#SungWanKim6"><b>Sung Wan Kim</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#JindrichKopecek6"><b>Jindrich Kopecek</b></a> <o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#CarolLim6"><b>Carol Lim</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#ZhengRongLu6"><b>Zheng-Rong Lu</b></a><o:p></o:p></li> </ul> <li class=MsoNormal style='color:black;mso-list:l2 level1 lfo1;tab-stops: list .5in;background:whitesmoke'><a href="#2005Publications1"><b>2005 Publications</b></a><o:p></o:p></li> <ul type=circle> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#YouHanBae5"><b>You Han Bae</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#ThomasCheatham5"><b>Thomas Cheatham</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#JamesHerron5"><b>James Herron</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#WilliamHiguchi5"><b>William Higuchi</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#StevenKern5"><b>Steven Kern</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#SungWanKim5"><b>Sung Wan Kim</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#JindrichKopecek5"><b>Jindrich Kopecek</b></a> <o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#CarolLim5"><b>Carol Lim</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#ZhengRongLu5"><b>Zheng-Rong Lu</b></a><o:p></o:p></li> </ul> <li class=MsoNormal style='color:black;mso-list:l2 level1 lfo1;tab-stops: list .5in;background:whitesmoke'><a href="#2004Publications1"><b>2004 Publications</b></a><o:p></o:p></li> <ul type=circle> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#YouHanBae4"><b>You Han Bae</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#ThomasCheatham4"><b>Thomas Cheatham</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#JamesHerron4"><b>James Herron</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#WilliamHiguchi4"><b>William Higuchi</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#StevenKern4"><b>Steven Kern</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#SungWanKim4"><b>Sung Wan Kim</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#JindrichKopecek4"><b>Jindrich Kopecek</b></a> <o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#CarolLim4"><b>Carol Lim</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#ZhengRongLu4"><b>Zheng-Rong Lu</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#JohnMauger4"><b>John Mauger</b></a><o:p></o:p></li> </ul> <li class=MsoNormal style='color:black;mso-list:l2 level1 lfo1;tab-stops: list .5in;background:whitesmoke'><a href="#2003Publications1"><b>2003 Publications</b></a><o:p></o:p></li> <ul type=circle> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#YouHanBae3"><b>You Han Bae</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#ThomasCheatham3"><b>Thomas Cheatham</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#JamesHerron3"><b>James Herron</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#WilliamHiguchi3"><b>William Higuchi</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#StevenKern3"><b>Steven Kern</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#SungWanKim3"><b>Sung Wan Kim</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#JindrichKopecek3"><b>Jindrich Kopecek</b></a> <o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#CarolLim3"><b>Carol Lim</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#ZhengRongLu3"><b>Zheng-Rong Lu</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#JohnMauger3"><b>John Mauger</b></a><o:p></o:p></li> </ul> <li class=MsoNormal style='color:black;mso-list:l2 level1 lfo1;tab-stops: list .5in;background:whitesmoke'><a href="#2002Publications1"><b>2002 Publications</b></a><o:p></o:p></li> <ul type=circle> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#YouHanBae2"><b>You Han Bae</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#ThomasCheatham2"><b>Thomas Cheatham</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#JamesHerron2"><b>James Herron</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#WilliamHiguchi2"><b>William Higuchi</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#StevenKern2"><b>Steven Kern</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#SungWanKim2"><b>Sung Wan Kim</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#JindrichKopecek2"><b>Jindrich Kopecek</b></a> <o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#CarolLim2"><b>Carol Lim</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#ZhengRongLu2"><b>Zheng-Rong Lu</b></a><o:p></o:p></li> </ul> <li class=MsoNormal style='color:black;mso-list:l2 level1 lfo1;tab-stops: list .5in;background:whitesmoke'><a href="#2001Publications1"><b>2001 Publications</b></a><o:p></o:p></li> <ul type=circle> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#YouHanBae1"><b>You Han Bae</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#WilliamHiguchi1"><b>William Higuchi</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#StevenKern1"><b>Steven Kern</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#SungWanKim1"><b>Sung Wan Kim</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#JindrichKopecek1"><b>Jindrich Kopecek</b></a> <o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#CarolLim1"><b>Carol Lim</b></a><o:p></o:p></li> </ul> <li class=MsoNormal style='color:black;mso-list:l2 level1 lfo1;tab-stops: list .5in;background:whitesmoke'><a href="#2000Publications1"><b>2000 Publications</b></a><o:p></o:p></li> <ul type=circle> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#JosephAndrade0"><b>Joseph Andrade</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#JamesHerron0"><b>James Herron</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#WilliamHiguchi0"><b>William Higuchi</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#StevenKern0"><b>Steven Kern</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#SungWanKim0"><b>Sung Wan Kim</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#JindrichKopecek0"><b>Jindrich Kopecek</b></a> <o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#CarolLim0"><b>Carol Lim</b></a><o:p></o:p></li> <li class=MsoNormal style='color:black;mso-list:l2 level2 lfo1;tab-stops: list 1.0in;background:whitesmoke'><a href="#JohnMauger0"><b>John Mauger</b></a><o:p></o:p></li> </ul> </ul> <p class=deptname><a name=A2007Publications1></a><a href="#A2007Publications1"><span style='mso-bookmark:A2007Publications1'><span style='mso-ascii-font-family: Verdana;mso-hansi-font-family:Verdana;mso-bidi-font-weight:normal'>2008 Publications:</span></span></a><span style='mso-bookmark:A2007Publications1'><span style='mso-bidi-font-family: Arial;font-weight:normal;mso-bidi-font-weight:bold'> <o:p></o:p> </span></span></p> <p class=deptname><a name=YouHanBae8></a><b><u><span style='font-family:"Arial","sans-serif";color:black'>You Han Bae</span></u></b></p> <p class="style6"> D. Kim, E.S. Lee, K.S. Park, I.C. Kwon, <strong>Y.H. Bae</strong>, Doxorubicin loaded pH-sensitive mixed micelle: antitumoral efficacy against ovarian A2780/DOXR tumor, <em>Pharm. Res.</em>, 25 (2008) 2074-2082. </p> <p class="style6">B.S. Jin, H.C. Kang, D. Kim, K.H. Lee, <strong>Y.H. Bae</strong>, Synthesis of poly(cystine bisamide)-PEG block copolymers grafted with 1-(3-aminopropyl) imidazole and their phase transition behaviors, <em>Polymer for Advanced Technologies</em>, (online pressed) </p> <p align="left" class="style6">E.S. Lee, Z. Gao, D. Kim, K. Park, I.C. Kwon, <strong>Y.H. Bae</strong>, Super pH-sensitive multifunctional polymeric micelle for tumor pHe specific TAT exposure and multidrug resistance,<em> J. Control. Rel.</em> 2008, <strong>129</strong>, 228-236. </p> <p align="left" class="style6">K.T. Oh, E.S. Lee, D.I. Kim, H. Yin, <strong>Y.H. Bae</strong>, L-Histidine based pH-sensitive anticancer drug carrier micelle: Reconstitution and brief evaluation of its systemic toxicity, <em>Int. J. Pharm.</em> 2008, <strong>358</strong>(1-2), 177-183. </p> <p align="left" class="style6">A. Taluja, Y.S. Youn, <strong>Y.H. Bae</strong>, Role of a novel multifunctional excipient poly(ethylene glycol)-<em>b</em>-oligo (vinyl sulfadimethoxine) in protein delivery from poly(lactide-co-glycolide) microspheres, <em>Int. J. Pharm.</em> 2008, <strong>358</strong>(1-2), 50-59.</p> <p align="left" class="style6">H. Yin, E.S. Lee, K.T. Oh, D.I. Kim, <strong>Y.H. Bae</strong>, Physicochemical properties of pH-sensitive poly(L-histidine)-<em>b</em>-poly(ethylene glycol)/ poly(L-lactide)-<em>b</em>-poly(ethylene glycol) mixed micelles, <em>J. Control. Rel.</em>, 2008, <strong>126</strong>(2), 130-138. </p> <p align="left" class="style6">V.A. Sethuraman, M.C. Lee, <strong>Y.H. Bae</strong>*, A biodegradable pH-sensitive micelle system for targeting acidic solid tumors, <em>Pharm. Res</em>. 2008, <strong>25</strong>(3), 657-666. (JIF 3.441 in 2007)</p> <p align="left" class="style6">E.S. Lee, D. Kim, Y.S. Youn, K.T. Oh, and <strong>Y.H Bae</strong>, A novel virus-mimetic nanogel vehicle, Angew. <em>Chem. Int. Ed</em>., 2008, <strong>47</strong>(13), 2418-2421.</p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <o:p></o:p></p> <p align="left"><a name=ThomasCheatham8></a><u><span class="style1">Thomas Cheatham</span></u></p> <p align="left" class="style6">In Suk Joung, and <strong>T.E. Cheatham, III. </strong>Determination of alkali and halide monovalent ion parameters for use in explicitly solvated biomolecular simulations</a>  <em>J. Phys. Chem. B</em>  112, 9020-9041 (2008). <p align="left" class="style6">H. Wang, <strong>T.E. Cheatham, III</strong>, and J. Lewis. Differential electronic states observed during the A-B DNA duplex conformational transitions.  <em>Soft Matter</em> (2008). [in review: submitted 8 Jan 08: B800462E]. <p align="left" class="style6">S. S. Pendley, Y. B. Yu, and <strong>T.E. Cheatham, III</strong>.  Molecular dynamics guided study of salt bridge length dependence in both fluorinated and non-fluorinated parallel dimeric coiled-coil proteins.  <em>Proteins</em> (2008) [in press; ASAP; DOI: 10.1002/prot.22177]. <p align="left" class="style6">D. Svozil, J.E. Sponer, I. Marchan, A. Perez, <strong>T.E. Cheatham, III</strong>, J. Luque, M. Orozco, and J. Sponer.  Geometrical and electronic structure variability of the sugar-phosphate backbone in nucleic acids.  <em>J. Phys. Chem. B </em> 112, 8188-8197 (2008). </p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <o:p></o:p></p> <o:p></o:p> <p align="left"><a name=DavidGrainger8></a><u><span class="style1">David Grainger</span></u></p> <p class="style6" style="margin-bottom:0in;margin-bottom:.0001pt">N. Ayres, D. J. Holt, C.F. Jones, L. E. Corum and <strong>D.W. Grainger*</strong>, Polymer Brushes Containing Sulfonated Sugar Repeat Units: Synthesis, Characterization and <em>In Vitro</em> Testing of Blood Coagulation Activation, 10.1002/pola.230752008, <em>J. Polym. Sci, A</em>, Polym Chem 46: 7713-7724, 2008. <p class="style6" style="margin-bottom:0in;margin-bottom:.0001pt">H. Takahashi, M. Dubey, K. Emoto, D.G. Castner, <strong>D.W. Grainger</strong>, Imaging surface immobilization chemistry: correlation with cell patterning on non-adhesive hydrogel thin films, <em>Adv. Funct. Mater</em>., 18 1-10 (2008); doi: 10.1002/adfm.200800105. <p class="style6" style="margin-bottom:0in;margin-bottom:.0001pt">P. Wu, D.G. Castner, <strong>D.W. Grainger</strong>, Diagnostic devices as biomaterials: a review of nucleic acid and protein microarray surface performance issues, <em>J. Biomat. Sci. Polym. Ed.,</em> 19(6) 725-753, (2008).</a> <p class="style6" style="margin-bottom:0in;margin-bottom:.0001pt"><strong>D.W. Grainger</strong>, D.G. Castner, Nanobiomaterials and nanoanalysis: how to improve the nanoscience for biotechnology , <em>Adv. Mater</em>. <em>20</em>, 867/ 877 (2008). </p> <p class=MsoNormal style6 style='margin:0in;margin-bottom:.0001pt'>&nbsp;</p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <o:p></o:p> </p> <p style="margin-bottom:0in;margin-bottom:.0001pt"><a name=HamidGhandehari8></a><b><u><span style='font-family:&quot;Arial&quot;, &quot;sans-serif&quot;; color:black'>Hamid Ghandehari</span></u></b></p> <p class="style6">K. Kitchens, R. B. Kolhatkar, P. W. Swaan, and <strong>H. Ghandehari,</strong> Endocytosis Inhibitors Prevent Poly (Amidoamine) Dendrimer Internalization and Permeability across Caco-2 Cells, <em>Molecular Pharmaceutics, </em>5: 364-369 (2008).<br> </p> <p class="style6">B. Zarabi, A. Nan, J. Zhuo, R. Gullapalli, and <strong>H. Ghandehari, </strong>A Multifunctional HPMA Copolymer Drug Delivery System: Synthesis, Characterization and In Vitro Evaluation, <em>Macromolecular Biosciences</em>, 2008 May 16. [Epub ahead of print]<br> </p> <p class="style6">A. Nan, X. Bai, S. J. Son, S. B. Lee*, and <strong>H. Ghandehari*,</strong> Cellular Uptake and Cytotoxicity of Silica Nanotubes, <em>Nano Letters, </em>accepted. <em>*Corresponding co-authors. </em><br> </p> <p class="style6">R. Kolhatkar, P. Swaan and <strong>H. Ghandehari,</strong> Potential Oral delivery of 7-Ethyl-10-Hydroxy-Camptothecin (SN-38) using Poly (Amidoamine) Dendrimers, <em>Pharmaceutical Research,</em> 25: 1723-1729 (2008).</p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <o:p></o:p></p> <p style="margin-bottom:0in;margin-bottom:.0001pt"><a name=JamesHerron8></a><b><u><span style='font-family:&quot;Arial&quot;, &quot;sans-serif&quot;; color:black'>James Herron</span></u></b></p> <p class="style6" style="margin-bottom:0in;margin-bottom:.0001pt">Suhonen, M., S. K. Li, W. I. Higuchi, and <strong>J. N. Herron</strong> (2008). A Liposome Permeability Model for Stratum<br> Corneum Lipid Bilayers Based on Commercial Lipids. Journal of Pharmaceutical Sciences 97, 4278-<br> 4293. E-publication ahead of print: January 31, 2008.</p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'>&nbsp;</p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <o:p></o:p> </p> <p style="margin-bottom:0in;margin-bottom:.0001pt"><a name=WilliamHiguchi8></a><b><u><span style='font-family:&quot;Arial&quot;, &quot;sans-serif&quot;; color:black'>William Higuchi</span></u></b></p> <p style="margin-bottom:0in;margin-bottom:.0001pt"><span class="style7"><span class="style8"><strong>W.I. Higuchi</strong>, C-S Tzeng, S-J Chang, H-J Chiang, C-L Liu.  Estimation of Cholesterol Solubilization by a Mixed Micelle Binding Model in Aqueous Tauroursodeoxycholate: Lecithin: Cholesterol Solutions, <em>J. Pharm. Sci.</em>, <u>97</u>, 340-349 (2008).</span></span></p> <p class="style6" style="margin-bottom:0in;margin-bottom:.0001pt">S.A. Molokhia, Y. Zhang, <strong>W.I. Higuchi</strong>, S.K. Li.  Iontophoretic Transport Across a Multiple Membrane System, <em>J. Pharm. Sci.</em>, <u>97</u>, 490-505 (2008).</p> <p class="style6" style="margin-bottom:0in;margin-bottom:.0001pt">M. Otsuka, A. Oshinbe, R.Z. LeGeros, Y. Tokudome, A. Ito, K. Otsuka and <strong>W.I. Higuchi</strong>.  Efficacy of the Injectable Calcium Phosphate Ceramics Suspensions Containing Magnesium, Zinc and Fluoride on the Bone Mineral Deficiency in Ovariectomized Rats, <em>J. Pharm. Sci.</em>, <u>97</u>, 421-432 (2008).</p> <p class="style6" style="margin-bottom:0in;margin-bottom:.0001pt">K. Tsutsumi, S.K. Li, R.V. Hymas, C-L. Teng, L.G. Tillman, G.E. Hardee, <strong>W.I. Higuchi</strong>, N.F.H. Ho.  Systematic Studies on the Paracellular Permeation of Model Oligonucleotides in the Rat Small Intestine with Chenodeoxycholate as Enhancer, <em>J. Pharm. Sci.</em>, <u>97</u>, 350-367 (2008). </p> <p class="style6">K.S. Warner, D.S. Shaker, S.A. Molokhia, Q. Xu, J. Hao, <strong>W.I. Higuchi</strong>, S.K. Li.  Silicone Elastomer Uptake Method for Determination of Free 1-Alkyl-2-Pyrrolidone Concentration in Micelle and Hydroxypropyl-_-Cyclodextrin Systems Used in Skin Transport Studies, <em>J. Pharm. Sci.</em>, <u>97</u>, 368-380 (2008).</p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <o:p></o:p></p> <p style="margin-bottom: .0001pt"><a name=SungWanKim8></a><strong><u><span class="style2">Sung Wan Kim</span></u></strong></p> <p class="style6">S.H. Kim, J.H. Jeong M. Ou, J.W. Yockman, <strong>S.W. Kim</strong>, and D.A. Bull, Cardiomyocyte-targeted siRNA Delivery by Prostaglandin E(2)-Fas siRNA Polyplexes Formulated with Reducible Poly(amido amine) for Preventing Cardiomyocyte Apoptosis, <em>Biomaterials</em>, <u>29:</u> 4439-46 (2008)</p> <p class="style6">M. Mossalam, J.-H. Jeong, E.D. Abel, <strong>S.W. Kim</strong>, and Y.-H. Kim, Reversal of Oxidative Stress in Endothelial Cells by Controlled Release of Adiponectin, <em>J. Control. Release</em>, <u>130:</u> 234-237 (2008)</p> <p class="style6">P. Kumar, H-S. Ban, S-S. Kim, H. Wu, T. Pearson, D.L. Greiner, A. Laouar, J. Yao, V. Haridas, K. Habiro, Y-G. Yang, J-H. Jeong, K-Y. Lee, Y-H. Kim, <strong>S.W. Kim</strong>, M. Peipp, G.H. Fey, N. Manjunath, L.D. Shultz, S-K. Lee, and P. Shankar, T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice, <em>Cell</em>, <u>134:</u> 1 (2008)</p> <p class="style6">C. He, <strong>S.W. Kim</strong>, and D.S. Lee, In Situ Gelling Stimuli-Sensitive Block Copolymer Hydrogels for drug Delivery, <em>J. Control. Release</em>, <u>127:</u> 189 (2008)</p> <p class="style6">S.H. Kim, J.H. Jeong, S.H. Lee, <strong>S.W. Kim</strong>, and T.G. Park, Local and Systemic Delivery of VEGF siRNA Using Polyelectrolyte Complex Micelles for Effective Treatment of Cancer, <em>J. Control. Release</em>, <u>129:</u> 107 (2008)</p> <p class="style6">Y. Lee, M.K. Kwon, E.S. Kang, Y.M. Park, S.H. Choi, C.W. Ahn, K.S. Kim, C.W. Park, B.S. Cha, <strong>S.W. Kim</strong>, J.K. Sung, E.J. Lee, and H.C. Lee, Adenoviral Vector-mediated Glucagon-like Peptide 1 Gene Therapy Improves Glucose Homeostasis in Zucker Diabetic Fatty Rats, <em>J. Gene Medicine</em>, <u>10:</u> 260 (2008)</p> <p class="style6">M. Ou, X-L. Wang, R. Xu, C-W. Chang, D.A. Bull, and <strong>S.W. Kim</strong>, Novel Biodegradable Poly(disulfide amine)s for Gene Delivery with High Efficiency and Low Cytotoxicity, <em>Bioconjugate Chemistry</em>, <u>19:</u> 626 (2008)</p> <p class="style6">D.P. Huynh, M.K. Nguyen, B.S. Pi, M.S. Kim, S.Y. Chae, K.C. Lee, B.S. Kim, <strong>S.W. Kim</strong>, and D.S. Lee, Functionalized Injectable Hydrogels for Controlled Insulin Delivery, <em>Biomaterials</em>, <u>29:</u> 2527 (2008)</p> <p class="style6">S. Lee, K. Kim H.A. Kim, <strong>S.W. Kim</strong>, and M. Lee, Augmentation of Erythropoietin Enhancer-Mediated Hypoxia-Inducible Gene Expression by Co-Transfection of a Plasmid Encoding Hypoxia-Inducible Factor 1a for Ischemic Tissue Targeting Gene Therapy, <em>J. Drug Targeting</em>, <u>16:</u> 43 (2008)</p> <p class="style6">C-W. Chang, L.V. Christensen, M. Lee, <strong>S.W. Kim</strong>, Efficient Expression of Vascular Endothelial Growth Factor Using Minicircle DNA for Angiogenic Gene Therapy, <em>J. Control. Release</em>, <u>125:</u> 155 (2008)</p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <o:p></o:p></p> <p class=deptname><a name=JindrichKopecek8></a><b><u><span style='font-family:"Arial","sans-serif";color:black'>Jindrich Kopecek</span></u></b></p> <p class="style6">C. Xu, <strong>J. Kopecek</strong>, Genetically Engineered Block Copolymers: Influence of the Length and Structure of the Coiled-Coil Block on Hydrogel Self-Assembly, <em>Pharmaceutical Res.</em>, 25, 674-682 (2008)</p> <p class="style6">H. Pan, <strong>J. Kopecek</strong>, Multifunctional Water-Soluble Polymers for Drug Delivery, <em>In: Multifunctional Pharmaceutical Nanocarriers (Fundamental Biomedical Technologies, Vol. 4)</em> V.P. Torchilin, Ed., Springer, New York, 2008, pp. 81-142.</p> <p class="style6"> J. Hongrapipat, P. Kopeckova, S. Prakongpan, <strong>J. Kopecek</strong>, Enhanced Antitumor Activity of Combinations of Free and HPMA Copolymer-bound Drugs, <em>Int. J. Pharmaceutics</em>, 351, 259-270 (2008) </p> <p class="style6">S.-Q. Gao, Y. Sun, P. Kopeckova, C.M. Peterson, <strong>J. Kopecek</strong>, Pharmacokinetic Modeling of Absorption Behavior of 9-Aminocamptothecin (9-AC) Released from Colon-specific HPMA Copolymer: 9-AC Conjugate in Rats, <em>Pharmaceutical Res.</em>, 25, 218-226 (2008)<br> </p> <p class="style6">J. Yang, K. Wu, C. Konak, <strong>J. Kopecek</strong>, Dynamic Light Scattering Study of the Self-Assembly of HPMA Hybrid Graft Copolymers, <em>Biomacromolecules</em>, 9, 510-517 (2008) </p> <p class="style6">K. Wu, J. Yang, C. Konak, P. Kopeckova, <strong>J. Kopecek</strong>, Novel Synthesis of HPMA Copolymers Containing Peptide Grafts and their Self-Assembly into Hybrid Hydrogels, <em>Macromol. Chem. Phys.</em>, 209, 467-475 (2008)</p> <p class="style6">V. Cuchelkar, P. Kopeckova, <strong>J. Kopecek</strong>, Synthesis and Biological Evaluation of Disulfide-Linked HPMA Copolymer- Mesochlorin e6 Conjugates, <em>Macromol. Biosci.</em>, 8, 375-383 (2008) </p> <p class="style6">H. Pan, J. Liu, Y. Dong, M. Sima, P. Kopeckova, M.L. Brandi, <strong>J. Kopecek</strong>, Release of Prostaglandin E1 from <em>N</em>-(2-Hydroxypropyl)methacrylamide Copolymer Conjugates by Bone Cells, <em>Macromol. Biosci.</em>, 8, 599-605 (2008) </p> <p class="style6">H. Pan, M. Sima, P. Kopeckova, K. Wu, S. Gao, J. Liu, D. Wang, S.C. Miller, <strong>J. Kopecek</strong>, Biodistribution and Pharmacokinetic Studies of Bone-Targeting <em>N</em>-(2-Hydroxypropyl)methacrylamide Copolymer: Alendronate Conjugates, <em>Molecular Pharmaceutics</em>, 5, 548-558 (2008)</p> <p class="style6">V. Cuchelkar, P. Kopeckova, <strong>J. Kopecek</strong>, Novel HPMA Copolymer-Bound Constructs for Combined Tumor and Mitochondrial Targeting, <em>Molecular Pharmaceutics</em>, 5, 776-786 (2008)</p> <p class="style6">J. Hongrapipat, P. Kopeckova, J. Liu, S. Prakongpan, <strong>J. Kopecek</strong>, Combination Chemotherapy and Photodynamic Therapy with Fab: Fragment Targeted HPMA Copolymer Conjugates in Human Ovarian Carcinoma Cells, <em>Molecular Pharmaceutics</em>, 5, 696-709 (2008)</p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <o:p></o:p></p> <p><a name=ZhengRongLu8></a><strong><u><span class="style2">Zheng-Rong Lu</span></u></strong></p> <p class="style6">X.-L. Wang, T. Nguyen, D. Gillespie, R. Jensen, <strong>Z.-R. Lu</strong>. A multifuncational and reversibly polymerizable carrier for efficient siRNA delivery. <em>Biomaterials</em>, 2008, 29, 15-22.</p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <o:p></o:p></p> <p style="margin-bottom: .0001pt"><a name=A2007Publications1></a><a href="#A2007Publications1"><span style='mso-bookmark:A2007Publications1'><span style='mso-ascii-font-family: Verdana;mso-hansi-font-family:Verdana;mso-bidi-font-weight:normal'>2007 Publications:</span></span></a><span style='mso-bookmark:A2007Publications1'><span style='mso-bidi-font-family: Arial;font-weight:normal;mso-bidi-font-weight:bold'> <o:p></o:p> </span></span></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><a name=YouHanBae7></a><b><u><span style='font-family:"Arial","sans-serif";color:black'>You Han Bae <o:p></o:p> </span></u></b></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'> <o:p></o:p> </span></u></b><span style='font-size:small; font-family: Arial, Helvetica, sans-serif'>V. Sethuraman</span><span style='font-size:small; font-family:Arial, Helvetica, sans-serif; mso-fareast-language:KO'>,</span><span style='font-size:small; font-family:Arial, Helvetica, sans-serif'> <strong>Y.H. Bae</strong>, TAT peptide based micelle system for active targeting of anti cancer agents to acidic solid tumors</span><span style='font-size:small; font-family:Arial, Helvetica, sans-serif; mso-fareast-language:KO'>, <em>J. Control. Rel</em>., </span><span style='font-size: small; font-family:Arial, Helvetica, sans-serif'>118</span><span style='font-size: small; font-family:Arial, Helvetica, sans-serif; mso-fareast-language:KO'>,</span><span style='font-size:small; font-family:Arial, Helvetica, sans-serif'> 216-224 </span><span style='font-size:small; font-family:Arial, Helvetica, sans-serif; mso-fareast-language: KO'>(2007). <o:p></o:p> </span></p> <p class="style6">H.C. Kang, <strong>Y.H. Bae</strong>, pH-Tunable endosomolytic oligomers for enhanced nucleic acid delivery, <em>Advanced Functional Materials</em>, 17, 1263-1272 (2007). <o:p></o:p> </p> <p class="style6"> A. Taluja, <strong>Y.H. Bae</strong>, Role of a novel excipient <span class=GramE>poly(</span>ethylene glycol)-b-poly(L-histidine) in retension of physical stability of insulin in aqueous solutions, <em>Pharm. Res.</em>, 24, 1517-1526 (2007). <o:p></o:p> </p> <p class="style6"> A. Taluja, <strong>Y.H. Bae</strong>, Role of a novel excipient poly(ethylene glycol)-<i style='mso-bidi-font-style:normal'>b</i>-poly(L-histidine) in retention of physical stability of insulin at the aqueous/organic solvent interface, <em>Mol. Pharm.</em>, 4, 561-570 (2007).<span style='mso-fareast-font-family:Batang'> <o:p></o:p> </span></p> <p class="style6"><span style='color:black'>G. Mohazer, E.S. Lee, <strong>Y.H. Bae</strong>, </span><span style='mso-fareast-font-family:Batang; color:black;layout-grid-mode:line'>Enhanced Intercellular Retention Activity of a Novel pH-sensitive</span> <span style='mso-fareast-font-family:Batang;color:black; layout-grid-mode:line'><span style='mso-spacerun:yes'>  </span></span><span style='color:black; layout-grid-mode:line'>Polymeric Micelles in </span><span style='mso-fareast-font-family:Batang; color:black;layout-grid-mode:line'>Wild</span><span style='color:black;layout-grid-mode:line'> and Multidrug Resistant <st1:stockticker w:st="on">MCF</st1:stockticker> -7 Cells, <em>Pharm. Res.</em>, 24, 1618-1627 (2007).</span> <o:p></o:p> </p> <p class="style6">L. Qiu, <strong>Y.H. Bae</strong>, </span><span style='mso-fareast-font-family: Batang;font-weight:normal;mso-bidi-font-weight:bold'>Self-assembled p</span><span style='font-weight:normal; mso-bidi-font-weight:bold'>olyethylenimine</span><span style='mso-fareast-font-family:Batang;font-weight: normal;mso-bidi-font-weight:bold'>-</span><span style='font-weight:normal;mso-bidi-font-weight: bold'>graf</span><span style='mso-fareast-font-family:Batang;font-weight:normal;mso-bidi-font-weight:bold'>t-poly(eð-</span><span style='font-weight:normal; mso-bidi-font-weight:bold'>caprolactone</span><span style='mso-fareast-font-family:Batang;font-weight: normal;mso-bidi-font-weight:bold'>) micelles </span><span style='mso-fareast-font-family:Batang; font-weight:normal'>a</span><span style='font-weight:normal'>s </span><span style='mso-fareast-font-family:Batang;font-weight:normal'>dual c</span><span style='font-weight:normal'>arrier </span><span style='mso-fareast-font-family:Batang;font-weight:normal'>of</span> <span style='mso-fareast-font-family:Batang;font-weight:normal'>g</span><span style='font-weight:normal'>enes and </span><span style='mso-fareast-font-family:Batang;font-weight:normal'>anticancer d</span><span style='font-weight:normal'>rugs, <em>Biomaterials</em>, 28, 4132-4142 (2007). <o:p></o:p></span></p> <p class="style6">K.T. Oh, H. Yin, E.S. Lee, <strong>Y.H. Bae</strong>, Polymeric nanovehicles for anticancer drugs with triggering release mechanisms, <em>J. Mater. Chem.</em>, 17, 3987-4001 (2007). </p> <span class="style6"> <o:p></o:p> </p> A. Taluja, Y.S. Youn, <strong>Y.H. Bae</strong>, Novel approaches in microparticulate PLGA delivery systems encapsulating proteins. <em>J. Mater. Chem.</em>, 17, 4002-4014 (2007). <o:p></o:p> </span> <p class="style6"> K. Na, E.S. Lee, <strong>Y.H. Bae</strong>, Self-organized nanogels responding to tumor extracellular pH: pH-dependent drug release and in vitro cytotoxicity against <st1:stockticker w:st="on">MCF</st1:stockticker> -7 wild and resistant cells. <em>Bioconj. Chem.</em>, 18, 1568-1574 (2007).<span style='color:red'> <o:p></o:p> </span></p> <p class="style6"> E.S. Lee, K.T. Oh, D. Kim, Y.S. Youn, <strong>Y.H. Bae*</strong>, <span style='mso-fareast-font-family:Gulim; mso-bidi-font-weight:bold'>Tumor pH-responsive flower-like micelle of <span class=GramE>poly(</span>L-lactic acid)-<i style='mso-bidi-font-style:normal'>b</i>-poly(ethylene glycol)-<i style='mso-bidi-font-style:normal'>b</i>-poly(L-histidine). <em>J. Control. Rel.</em>, 123, 19-26, (2007).<b> <o:p></o:p> </b></span></p> <p class="style6"> H.C. Kang, M.H. Lee, <strong>Y.H. Bae</strong>, Polymeric gene delivery vectors, in N.A. Peppas, J. Zach Hilt, and J. Brook (Eds), Nanotechnology in Therapeutics: Current Technology and Applications, Horizon Bioscience Press. 2007, pp. 131-161. <o:p></o:p> </p> <p class="style6"> E.S. Lee, <strong>Y.H. Bae</strong>, pH-Sensitive micelles targeting tumor pH, in M. Amiji (Ed.), Nanotechnology for Cancer Therapeutics, <st1:stockticker w:st="on">CRC</st1:stockticker> Press 2007, pp. 443-464. <o:p></o:p> </p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><a name=ThomasCheatham7></a><b><u><span style='font-family:"Arial","sans-serif";color:black'>Thomas Cheatham</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><a name=DavidGrainger7></a><b><u><span style='font-family:"Arial","sans-serif";color:black'>David Grainger<o:p></o:p></span></u></b></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p> </span></u></b><span class="style6">Dandy, P. Wu, <strong>D.W. Grainger</strong>, Assay feature size influences nucleic acid capture in DNA microarrays, <em>Proc. Natl. Acad. Sci.</em>, USA, (doi:10.1073/pnas.0606), 104(20) 8223-8228, 2007.</span></p> <p class="style6"> <o:p></o:p> <o:p></o:p> D. Xue, P. Gong, <strong>D.W. Grainger</strong>, C.M. Elliott, V. Disette, C.A. Bignozzi, S. <o:p></o:p> Caramori, Electrochemical detection of DNA hybridization through catalytic oxidation of Co(II) complexes by covalently bound or intercalated Ru(II) complexes, <em>J. Am. Chem. Soc.</em>, 129(7):1854-5 (2007). <o:p></o:p> </p> <p class="style6"><o:p></o:p> C-Y Lee, P-C.T. Nguyen, <strong>D.W. Grainger</strong>, L.J. Gamble, D.G. Castner, Structure and DNA Hybridization Properties of Mixed Nucleic Acid/Maleimide-ethylene glycol monolayers, <em>Analyt. Chem.</em>, ACS ASAP DOI: 10.1021/ac0703395, published on line May, 2007: 79: 3390-3400 (2007). <o:p></o:p> </p> <o:p></o:p> <p class="style6"> I. C. Saldarriaga Fernández, H.C. van der Mei, M.J. Lochhead, <strong>D.W. Grainger</strong>, H.J. Busscher, The inhibition of the adhesion of clinically isolated bacterial strains on multi-component cross-linked poly(ethylene glycol)-based polymer coating, <em>Biomaterials</em>, doi:10.1016/j.biomaterials.2007.05.023, 28 4105-4112 (2007). <o:p></o:p> </p> <o:p></o:p> <p class="style6"> R. Kuijer, E.J.P. Jansen, P.J. Emans, S.K. Bulstra, J. Riesle, J. Pieper, <strong>D.W. Grainger</strong>, H.J. Busscher, Assessing infection risk in implanted tissue engineered devices, <em>Biomaterials</em>, doi 10.1016/j.biomaterials.2007.06.003; <o:p></o:p>28(34):5148-5154. </p> <o:p></o:p> <p class="style6">J.A. Auer, A. Goodship , S. Arnoczky, S. Pearce, J. Price, L. Claes , B. von Rechenberg, M. Hofmann-Amtenbrinck, E. Schneider, R. Muller-Terpitz, F. <o:p></o:p> Thiele, K-P. Rippe, <strong>D. W. Grainger</strong>, Refining animal models in fracture research: seeking consensus for optimization of both welfare and scientific validity for appropriate biomedical use, <em>BMC Musculoskel. Disorders</em> 8:72 2007, doi:10.1186/1471-2474-8-72, published on-line August, 2007. </p> <o:p></o:p> <p class="style6">C.Y. Lee, G.M. Harbers, <strong>D.W. Grainger</strong>, L.J. Gamble, D.G. Castner, Fluorescence, XPS and ToF-SIMS Surface Chemical State Image Analysis of DNA Microarrays, <em>J. Am. Chem. Soc.</em>, ACS ASAP 10.1021/ja071879m, 129 9429-9438 (2007). <o:p></o:p> </p> <o:p></o:p> <p class="style6">G. Harbers, K. Emoto, C. Greef. S. Metzger, <strong>D.W. Grainger</strong>, M. Lochhead, A functionalized poly(ethylene glycol) bioassay surface chemistry facilitates bio-immobilization and inhibits non-specific protein, bacterial, and mammalian cell adhesion, <em>Chem. Mater.</em>, ASAP doi 10.1021/cm070509u, 19, <o:p></o:p> 4405-4414 (2007). </p> <o:p></o:p> <p class="style6"><strong>D.W. Grainger</strong>, Peer review as professional responsibility: a quality control system only as good as the participants, <em>Biomaterials</em>, <o:p></o:p> doi:10.1016/j.biomaterials.2007.07.004 28 5199-5203 (2007). </p> <o:p></o:p> <p class="style6">F. Cheng, L.J. Gamble, <strong>D.W. Grainger</strong>, D.G. Castner, X-ray Photoelectron Spectroscopy, Time-of-flight Secondary Ion Mass Spectrometry and Principal Component Analysis of the Hydrolysis, Regeneration and Reactivity of NHS-containing Organic Thin Films, (ac0715423) <em>Analyt. Chem.</em>, 10.1021/ac0715423, 79(22) 8781-8788 (2007). <o:p></o:p> </p> <o:p></o:p> <p class="style6">H. Takahashi, D. Letourneur, <strong>D.W. Grainger</strong>, Delivery of large biopharmaceuticals from cardiovascular stents: a review, <em>Biomacromolecules</em>, 10.1021/bm700540p, published on Web 10/12/2007;  8(11) 3281-3293 2007. <o:p></o:p> </p> <o:p></o:p> <p class="style6">P. Wu, D.G. Castner, <strong>D.W. Grainger</strong>, Diagnostic devices as biomaterials: a review of nucleic acid and protein microarray surface performance issues, <em>J. Biomat. Sci. Polym. Ed.</em>, in press, 2007. <o:p></o:p> </p> <o:p></o:p> <p class="style6">M.L. Godek, R. Michel, L.M. Chamberlain, D.G. Castner, <strong>D.W. Grainger</strong>, Adsorbed serum albumin is permissive to macrophage attachment to polymer surfaces in culture, <em>J. Biomed. Mat. Res.</em>, in press, (2007). <o:p></o:p> </p> <o:p></o:p> <p class="style6">C. M. Santoro, N.L. Duchsherer, <strong>D. W. Grainger</strong>, Minimal antimicrobial efficacy and ocular cell toxicity from silver nanoparticles, in press, <em>Nanobiotechnology</em>, 2007. <o:p></o:p> </p> <o:p></o:p> <p class="style6">L.M. Chamberlain, M.L. Godek, M. Gonzalez-Juarrero, <strong>D.W. Grainger</strong>, Comparison of murine macrophage cell models for in vitro assessment of the foreign body response, in press, <em>J. Biomed. Mater. Res.</em>, 2007. <o:p></o:p> </p> <o:p></o:p> <p class="style6"><strong>D.W. Grainger</strong>, D.G. Castner, Nanobiomaterials and nanoanalysis: how to improve the nanoscience for biotechnology, in press, <em>Adv. Mater.</em>, (2007). <o:p></o:p> </p> <o:p></o:p> <p class="style6">C-Y Lee, L.J. Gamble, G.M. Harbers, P. Gong, <strong>D.W. Grainger</strong>, D.G. Castner, Multi-technique characterization of DNA-modified surfaces for biosensing and diagnostic applications in Surface Analysis and Techniques in Biology, ed. V. S. Smentkowski, Springer, New York, NY, in press, 2007. <o:p></o:p> </p> <o:p></o:p> <p class="style6"> M.L. Godek, <strong>D.W. Grainger</strong>, The Macrophage in Wound Healing Surrounding Implanted Devices, in Implantable Glucose Sensing, Wiley, NY, in press, 2007. <o:p></o:p> </p> <o:p></o:p> <p class="style6">B. von Rechenberg, L. Meinel, <strong>D.W. Grainger</strong>, M. Hofman-Amtenbrink, Introduction to Biotechnology, in AO Principles of Fracture Management, (2nd ed.), T. Ruedi, ed., AO Publishing, AO Foundation, Davos, Switzerland, pp.47-68, 2007. <o:p></o:p> </p> <p class="style6"> P. Gong, <strong>D.W. Grainger</strong>, Non-Fouling Surfaces: A Review of Principles and Applications for Microarray Capture Assay Designs in Microarrays: Methods and Protocols, 2nd Ed. (Methods in Molecular Biology), R. Rampal, ed., Humana Press, NJ, USA, pp. 59-92, 2007. <o:p></o:p> </p> <o:p></o:p> <p><span class="style6"><strong>D.W. Grainger</strong>, C.A. Greef, P. Gong, M. Lochhead, Surface Chemistry in Commercial Microarraying in Microarrays: Methods and Protocols 2nd ed., (Methods in Molecular Biology), R. Rampal, ed., Humana Press, NJ, USA, pp. <o:p></o:p> 37-57, 2007 </span><span style='mso-tab-count:1'>              </span> <o:p></o:p> </p> <p class=MsoPlainText style='tab-stops:96.0pt'><o:p></o:p> <a href="#top"><b style='mso-bidi-font-weight:normal'><span class="style6" style='color:#632423'>(B</span></b><span class="style6"><strong><span style='color:#632423'>ack to the top)</span></strong></span></a> <span class="style6"> <o:p></o:p> </span><span class="style6"> </span></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><a name=HamidGhandehari7></a><b><u><span style='font-family:"Arial","sans-serif";color:black'>Hamid Ghandehari<o:p></o:p></span></u></b></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'><o:p><span class="style6" style='text-decoration:none'>&nbsp;</span></o:p></span></u></b><span class="style6">A. Mitra, A. Nan, B. R. Line, <strong>H. Ghandehari</strong>, Polymeric Conjugates for Angiogenesis Targeted Tumor Imaging and Therapy, In Nanotechnology For Cancer Therapeutics, Amiji (Ed), </span></p> <span class="style6"> <st1:stockticker w:st="on">CRC</st1:stockticker> Press, Boca Raton, Florida, pp 159-184 (2007). <o:p></o:p> </p> </span> <p class=MsoPlainText style7 style8><o:p>&nbsp;</o:p></p> <span class="style6">A. Hatefi and <strong>H. Ghandehari</strong>, Adenoviral Gene Delivery to Solid Tumors by Recombinant Silk-Elastinlike Polymers, <em>Pharmaceutical Research</em>, 4: 773-779 (2007). <o:p></o:p> </p> </span> <p class=MsoPlainText style7 style8><o:p>&nbsp;</o:p></p> <span class="style6">R. Dandu, and <strong>H. Ghandehari</strong>, Delivery of Bioactive Agents from Recombinant Polymers, <em>Progress in Polymer Science</em>, 32: 1008/1030 (2007). <o:p></o:p> </p> </span> <p class=MsoPlainText style7 style8><o:p>&nbsp;</o:p></p> <span class="style6">K. Kitchens, A. Foraker, R. Kolhatkar, P. Swaan and <strong>H. Ghandehari</strong>, Endocytosis and Interaction of Poly (Amidoamine) Dendrimers with Caco-2 Cells, <em>Pharmaceutical Research</em>, 24:2138-2145 (2007). <o:p></o:p> </p> </span> <p class=MsoPlainText style7 style8><o:p>&nbsp;</o:p></p> <span class="style6">R. Kolhatkar, K. Kitchens, P. Swaan and <strong>H. Ghandehari</strong>, Surface Acetylation of Poly(Amidoamine) (PAMAM) Dendrimers Decreases Cytotoxicity while Maintaining Membrane Permeability, <em>Bioconjugate Chemistry</em>, 18:2054-2060 (2007). <o:p></o:p> </p> </span> <p class=MsoPlainText style7 style8><o:p>&nbsp;</o:p></p> <span class="style6">S. S. Chandran, A. Nan, D. M. Rosen, <strong>H. Ghandehari</strong>, S. R. Denmeade,  A Prostate-Specific Antigen ( <st1:stockticker w:st="on">PSA</st1:stockticker> )-Activated HPMA Copolymer Prodrug As Dual-Targeted Therapy For Prostate Cancer, <em>Molecular Cancer Therapeutics</em>, 6: 2928-2937 (2007). <o:p></o:p> </p> </span> <p class=MsoPlainText style7 style8><o:p>&nbsp;</o:p></p> <span class="style6"><strong>H. Ghandehari</strong>, Recombinant Biomaterials for Pharmaceutical and Biomedical Applications, <em>Pharmaceutical Research</em>, 2007 [Epub ahead of print]. <o:p></o:p> </p> </span> <p class=MsoPlainText style7 style8><o:p>&nbsp;</o:p></p> <span class="style6">M. Haider, J. Cappello, <strong>H. Ghandehari </strong>and K. Leong, In Vitro Chondrogenesis of Mesenchymal Stem Cells in Recombinant Silk-Elastinlike Hydrogels, <em>Pharmaceutical Research</em>, 2007 [Epub ahead of print]. <o:p></o:p> </p> </span> <p class=MsoPlainText><o:p>&nbsp;</o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><a name=JamesHerron7></a><b><u><span style='font-family:"Arial","sans-serif";color:black'>James Herron<o:p></o:p></span></u></b></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p> </span></u></b><span class="style6">Guo, J., P. Elzinga, M. Hageman and <strong>J. Herron</strong>. Rapid Throughput Solubility Screening Method for </span></p> <span class="style6"> <st1:stockticker w:st="on">BCS</st1:stockticker> Class II Drugs in Animal GI Fluids and Simulated Human GI Fluids Using a 96-well Format. <em>Journal of Pharmaceutical Science</em>.  E-publication ahead of print: <st1:date ls="trans" Month="8" Day="27" Year="2007" w:st="on">August 27, 2007</st1:date> . <o:p></o:p> </p> </span> <p class=MsoPlainText style7 style8><o:p>&nbsp;</o:p></p> <span class="style6">Guo, J., P. Elzinga, M. Hageman, and <strong>J. Herron</strong>. Rapid Throughput Screening of Apparent Ksp values for Weakly Basic Drugs Using 96-Well Format. <em>Journal of Pharmaceutical Science</em>.  E-publication ahead of print: <st1:date ls="trans" Month="9" Day="18" Year="2007" w:st="on">September 18, 2007</st1:date> . <o:p></o:p> </p> </span> <p class=MsoPlainText style7 style8><o:p>&nbsp;</o:p></p> <span class="style6">Wei, A.-P and<strong> J. N. Herron</strong>. Assay Procedure Using Fluorogenic Tracers. U.S. Patent No. 7,153,654 (issued <st1:date ls="trans" Month="12" Day="26" Year="2006" w:st="on">12/26/06</st1:date> ) <o:p></o:p> </p> </span> <p class=MsoPlainText style7 style8><o:p>&nbsp;</o:p></p> <span class="style6"><strong>Herron, J. N.</strong>, D. A. Christensen, V. A. Pollak, R. D. McEachern, and E. M. Simon. Lens and Associatable Flow Cell.  U.S. Patent No. RE39,772 (Reissued 08/14/07) <o:p></o:p> </p> </span> <p class=MsoPlainText><o:p>&nbsp;</o:p></p> <p class=MsoNormal style7 style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><o:p></o:p> </p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'> <a name=WilliamHiguchi7></a><b><u><span style='font-family:"Arial","sans-serif";color:black'>William Higuchi <o:p></o:p> </span></u></b></p> <p class=MsoNormal style8 style7>S.K. Li, H. Zhu, W.I. Higuchi.&nbsp; &quot;Enhanced Transscleral Iontophoretic Transport with Ion Exchange Membrane&quot;, <u>Pharm. Res.</u>, <u>23</u>, 1857-1867 (2006).&nbsp;<o:p></o:p></p> <p class=MsoNormal style8 style7>S.A. Molokhia, E-K. Jeong, W.I. Higuchi and S.K. Li.&nbsp; &quot;Examination of Penetration Iontophoresis with Magnetic Resonance Imaging&quot;, <u>Int. J. Pharm.</u>, <u>335</u>, 46-53 (2007).<o:p></o:p></p> <p class=MsoNormal style8 style7>D. Chantasart, P. Sa-Nguandeekul, S. Prakongpan, S.K. Li, and W.I. Higuchi.&nbsp; &quot;Comparison of the Effects of Chemical Permeation Enhancers on the Lipoidal Pathways of Human Epidermal Membrane and Hairless Mouse Skin and the Mechanism of Enhancer Action&quot;, <u>J. Pharm. Sci.</u>, <u>96</u>, 2310-2326 (2007).<o:p></o:p></p> <p class=MsoNormal style8 style7>D. Wang, S.C. Miller, L.S. Shlyakhtenko, A.M. Portillo, X-M Liu, K. Papangkorn, P. Kopeckova, Y. Lyubchenko, W.I. Higuchi and J. Kopecek.&nbsp; &quot;Osteotropic Peptide that Differentiates Functional Domains of the Skeleton&quot;, <u>Bioconj. Chem.</u>, <u>18</u>, 1375-1378 (2007).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><a name=StevenKern7></a><b><u><span style='font-family:"Arial","sans-serif";color:black'>Steven Kern</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><a name=SungWanKim7></a><b><u><span style='font-family:"Arial","sans-serif";color:black'>Sung Wan Kim</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><a name=JindrichKopecek7></a><b><u><span style='font-family:"Arial","sans-serif";color:black'>Jindrich Kopecek <o:p></o:p></span></u></b></p> <p class=MsoNormal style7 style8>J. Kopecek, Hydrogel Biomaterials: A Smart Future? Biomaterials, 28, 5185-5192 (2007) <o:p></o:p></p> <p class=MsoNormal style7 style8>D. Wang, S.C. Miller, L.S. Shlyakhtenko, A.M. Portillo, X.-M. Liu, K. Papangkorn, P. Kopeckova, Y. Lyubchenko, W.I. Higuchi, J. Kopecek, Osteotropic Peptide That Differentiates Functional Domains of the Skeleton, Bioconjugate Chem., 18, 1375-1378 (2007) <o:p></o:p></p> <p class=MsoNormal style7 style8>A. Malugin, P. Kopeckova, J. Kopecek, Liberalization of Doxorubicin from HPMA Copolymer Conjugate is Essential for the Induction of Cell Cycle Arrest and Nuclear Fragmentation in Ovarian Carcinoma Cells, J. Control. Release, 124, 6-10 (2007) <o:p></o:p></p> <p class=MsoNormal style7 style8>J. Kopecek. J. Yang, Hydrogels as Smart Biomaterials, Polymer Int., 56, 1078-1098 (2007) <o:p></o:p></p> <p class=MsoNormal style7 style8>H. Pan, P. Kopeckova, J. Liu, D. Wang, S.C. Miller, J. Kopecek, Stability in Plasmas of Various Species of HPMA Copolymer-PGE1 Conjugates, Pharmaceutical Res., 24, 2270-2280 (2007) <o:p></o:p></p> <p class=MsoNormal style7 style8>S. Gao, Z.-R. Lu, P. Kopeckova, J. Kopecek, Biodistribution and Pharmacokinetics of Colon-Specific HPMA Copolymer 9-Aminocamptothecin Conjugate in Mice, J. Control. Release, 117, 179-185 (2007) <o:p></o:p></p> <p class=MsoNormal style7 style8>H. Ding, P. Kopeckova, J. Kopecek, Self-Association Properties of HPMA Copolymers Containing an Amphipatic Heptapeptide, J. Drug Targeting, 15, 465-474 (2007) <o:p></o:p></p> <p class=MsoNormal style7 style8>J. Kopecek, Polymeric Biomaterials and Drug Delivery Systems, J. Jpn. Biomat. Soc., 25, 123-135 (2007) <o:p></o:p></p> <p class=MsoNormal style7 style8>C. Xu, J. Kopecek, Self-Assembling Hydrogels, Polymer Bulletin, 58, 53-63 (2007) <o:p></o:p></p> <p class=MsoNormal style7 style8>C. Xu, J. Kopecek, Genetically Engineered Block Copolymers: Influence of the Length and Structure of the Coiled-Coil Block on Hydrogel Self-Assembly, Pharmaceutical Res., (2007) doi:10.1007/s11095-007-9343-z <o:p></o:p></p> <p class=MsoNormal style7 style8>J. Hongrapipat, P. Kopeckova, S. Prakongpan, J. Kopecek, Enhanced Antitumor Activity of Combinations of Free and HPMA Copolymer-bound Drugs, Int. J. Pharmaceutics, (2007) doi:10.1016/j.ijpharm.2007.09.018 <o:p></o:p></p> <p class=MsoNormal style7 style8>S.-Q. Gao, Y. Sun, P. Kopeckova, C.M. Peterson, J. Kopecek, Pharmacokinetic Modeling of Absorption Behavior of 9-Aminocamptothecin (9-AC) Released from Colon-specific HPMA Copolymer 9-AC Conjugate in Rats, Pharmaceutical Res., (2007) doi:10.1007/s11095-007-9465-3 <o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><a name=CarolLim7></a><b><u><span style='font-family:"Arial","sans-serif";color:black'>Carol Lim<o:p></o:p></span></u></b></p> <p class=MsoNormal><b style='mso-bidi-font-weight:normal'><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>Lim, C.S.</span></b> Organelle-specific targeting in drug delivery and design.<span style='mso-spacerun:yes'>  </span>Advanced Drug Delivery Reviews, 59(8), Aug 10, 2007.<span style='mso-spacerun:yes'>  </span>Theme editor also of this issue.<o:p></o:p></span></p> <p class=MsoNormal style='text-align:justify'>Kakar, M., Davis, J.R., Kern, S.E., and <b style='mso-bidi-font-weight:normal'>Lim, C.S.</b><span style='mso-spacerun:yes'>  </span>Optimizing the protein switch: altering nuclear import and export signals, and ligand binding domain, Journal of Controlled Release, 2007 Jul 31;120(3):220-32. Epub 2007 May 3.<o:p></o:p></p> <p class=MsoNormal style='text-align:justify'>Kakar, M., Cadwallader, A.B., Davis, J.R., and <b style='mso-bidi-font-weight:normal'>Lim, C.S.</b><span style='mso-spacerun:yes'>  </span>Signal sequences for targeting of gene therapy products to subcellular compartments:<span style='mso-spacerun:yes'>  </span>The role of <st1:stockticker w:st="on">CRM</st1:stockticker>1 in nucleocytoplasmic shuttling of the protein switch.<span style='mso-spacerun:yes'>  </span>Pharm Res, 2007 Jun 13; [Epub ahead of print]<o:p></o:p></p> <p class=MsoNormal style='text-align:justify'>Davis, J.R., Kakar, M., and <b style='mso-bidi-font-weight:normal'>Lim, C.S.</b><span style='mso-spacerun:yes'>  </span>Controlling Protein Compartmentalization to Overcome Disease.<span style='mso-spacerun:yes'>  </span><i style='mso-bidi-font-style: normal'>Pharmaceutical Research</i>, <span class=ti2><span style='mso-ansi-font-size: 10.0pt;mso-bidi-font-size:10.0pt'>24(1) January, 2007, Epub Sep 13 2006.</span></span><o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><a name=ZhengRongLu7></a><b><u><span style='font-family:"Arial","sans-serif";color:black'>Zheng-Rong Lu<o:p></o:p></span></u></b></p> <p class="style6" style='margin-bottom:0in;margin-bottom:.0001pt'>Ke, E.K. Jeong, X. Wang, Y. Feng, D.L. Parker, Z.-R. Lu, RGD targeted poly(L-glutamic acid)-cystamine-(Gd-DOTA) for MR imaging of angiogenesis. Intl. J. Nanomed.<span style='mso-spacerun:yes'>  </span>2007, 2, 191-9.</p> <p class="style6" style='margin-bottom:0in;margin-bottom:.0001pt'><span class="style6"> <o:p></o:p> </span><span class="style6">S.Q. Gao, Z.R. Lu, P. Kopeckova, J. Kopecek</span></a>, Biodistribution and pharmacokinetics of colon-specific HPMA copolymer-9-aminocamptothecin conjugate in mice.  J. Controlled Rel.  2007, 117, 179-185. <o:p></o:p> </p> <p class="style6">Y. Wang, F. Ye, E.-K. Jeong, Y. Sun, D. L. Parker, Z.-R. Lu, Noninvasive visualization of pharmacokinetics, biodistribution and tumor targeting of poly[N-(2-hydroxypropyl)methacrylamide] in mice </span>using</span> contrast enhanced <st1:stockticker w:st="on">MRI</st1:stockticker> .  Pharm. Res. 2007, 6, 1208-16. <o:p></o:p> </p> <p class="style6">A Mohs, Z.-R. Lu, Gadolinium(III)-Based Blood Pool Contrast Agents for Magnetic Resonance Imaging: Current Status and Clinical Potential. Expert Opinion on Drug Delivery.<span style='mso-spacerun:yes'>  </span>2007, 4, 149-164. <o:p></o:p> </p> <p class="style6">A. Mohs, T. Nguyen, E.-K. Jeong, Y. Feng, L. Emerson, Y. Zong, D.L. Parker, Z.-R. Lu, <o:p></o:p> Pegylation of Gd-DTPA Cystine Copolymers Improves Pharmacokinetics and Tissue Retention for Magnetic Resonance Angiography.<span style='mso-spacerun:yes'>  </span> <st1:stockticker w:st="on">MRM</st1:stockticker> . 2007, 58, 110-8. <o:p></o:p> </p> <p class="style6">T.L. Kanneshiro, X.-L. Wang, Z.-R. Lu, Synthesis and Characterization of Globular <i style='mso-bidi-font-style: normal'>L</i>-Lysine Dendrimers with a Cubic Octa(3-aminopropyl)silsesquioxane Core. Mol. Pharm. 2007, 4, 759-68. <o:p></o:p> </p> <p class="style6">R. Xu, Y. Wang, X. Wang, E.-K. Jeong, D.L. Parker and Z.-R. Lu, In Vivo Evaluation of a PAMAM-Cystamine-(Gd-DO3A) Conjugate as a Biodegradable Macromolecular <st1:stockticker w:st="on">MRI</st1:stockticker> Contrast Agent.<span style='mso-spacerun:yes'>  </span>Exp. Biol. Med. 2007, 232, 1081-9. <o:p></o:p> </p> <p class="style6">Z.-R. Lu, Application of biomedical imaging in drug discovery and development.<span style='mso-spacerun:yes'>  </span>Pharm. Res. 2007, 6, 1170-1. <o:p></o:p> </p> <p class="style6">X.L. Wang, R. Jensen, and Z.-R. Lu, An novel environment-sensitive biodegradable cationic polydisulfide for nucleic acid delivery.<span style='mso-spacerun:yes'>  </span>J. Control. Rel.<span style='mso-spacerun:yes'>  </span>2007, 120, 250-8. <o:p></o:p> </p> <p class="style6">S. Sakuma, T. Matsumoto, S. Yamashita, Y. Wang, Z.-R. Lu, Conjugation of poorly absorptive drugs with mucoadhesive polymers for the improvement of oral absorption of drugs. J. Control. Rel.<span style='mso-spacerun:yes'>  </span>2007, 123, 195-202. <o:p></o:p> </p> <span class="style6">Z.-R. Lu, F. Ye and A. Vaidya, Polymer Platform for Drug Delivery and Biomedical Imaging. J. Control. Release.  2007. 122, 269-77</span>.<span style='mso-spacerun:yes'>  </span> <o:p></o:p> <o:p></o:p> </p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'>&nbsp;</p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <o:p></o:p> </p> <p class=deptname>2006 Publications:<a name=2006Publications1></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><a name=YouHanBae6></a><b><u><span style='font-family:"Arial","sans-serif";color:black'>You Han Bae</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>H.C. Kang, M.H. Lee, Y.H. Bae, Polymeric Gene Carrier, Critical ReviewsTM in Eukaryotic Gene, Expression</span></em>, 15, 317-342 (2005).<o:p></o:p></p> <p>K. Na, K.H. Lee, D.H. Lee, Y.H. Bae, Biodegradable Thermo-sensitive Self-assembled Nanoparticles from Poly(ethylene glycol)(PEG)/poly(L-lactic acid)(PLLA) Alternating Multiblock Copolymer for Potential Anticancer Drug Delivery, Eur. J. Pharm. Sci.</span></em>, 27, 115-122 (2006).<o:p></o:p></p> <p>L. Qiu, Y.H. Bae, Polymer Architecture and Drug Delivery, Pharm. Res.</span></em>, 23, 1-30 (2006).<o:p></o:p></p> <p>W.J. Sung, YH Bae, Glucose Oxidase, Lactate Oxidase, and Galactose Oxidase Enzyme Electrode Based on Polypyrrole with Polyanion/PEG/enzyme Conjugate Dopant, Sensors and Actuators. B.</span></em>, 114, 164-169 (2006).<o:p></o:p></p> <p>W. Zhu, T. Masaki, Y.H. Bae, R. Rathi, A.K. Cheung, S.E. Kern, Development of a Sustained-release System for Perivascular Delivery of Dipyridamole, J. Biomed. Mater. Res. B. Appl. Biomater.</span></em>, 77B, 135-143 (2006).<o:p></o:p></p> <p>V.A. Sethuraman, K. Na, Y.H. Bae, pH-responsive Sulfonamide/PEI System for Tumor Specific Gene Delivery: In vitro study, Biomacromolecules</span></em>, 7, 64-70 (2006).<o:p></o:p></p> <p>J. Lee, Y.H. Bae, Y.S. Sohn, B. Jeong, Thermogelling Aqueous Solutions of Alternating Multiblock Copolymers of Poly(L-lactic acid) and Poly(ethylene glycol), Biomacromolecules</span></em>, 7, 1729-1734 (2006).<o:p></o:p></p> <p>H.C. Kang, Y.H. Bae, Polymeric Gene Transfection on Insulin-secreting Cells: Sulfonylurea Receptor-mediation and Transfection Medium Effect, Pharm. Res.</span></em>, 23, 1797-1734 (2006).<o:p></o:p></p> <p>K. Na, D.H. Lee, D.J. Hwang, K.H. Lee, Y.H. Bae, pH-Sensitivity and pH-dependent Structural Change in Polymeric Nanoparticles of Poly(vinyl sulfadimethoxine)-deoxycholic Acid Conjugate, Eur. Polym. J.</span></em>, 42, 2581-2588 (2006).<o:p></o:p></p> <p>K. Na, V. Sethuraman, Y.H. Bae, Stimuli-sensitive Polymeric Micelles as Anticancer Drug Carriers, Current Medicinal Chemistry: Anti-Cancer Agents</span></em>, 6, 525-535 (2006).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=ThomasCheatham6></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>Thomas Cheatham</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>T.E. Cheatham, III, D.A. Case, Using AMBER to Simulate DNA and RNA in <em><span style='font-family:"Arial","sans-serif"'>Computational Studies of RNA and DNA</span></em> (Springer, The Netherlands, Editors: J. Sponer, F. Lankas), 45-72 (2006)<o:p></o:p></p> <p>N. Spackova, T.E. Cheatham, III, J. Sponer, Molecular Dynamics Simulations of Nucleic Acids in <em><span style='font-family:"Arial","sans-serif"'>Computational Studies of RNA and DNA</span></em> (Springer, The Netherlands, Editors: J. Sponer, F. Lankas), 301-326 (2006)<o:p></o:p></p> <p>T. N. Truong, M. Nayak, H. Huynh, T. Cook, P. Marajan, L.T. Tran, J. Bharath, S. Jain, H.B. Pham, N. Nguyen, Y. Kim, S. Choe, T.E. Cheatham, III, J. Facelli, Computational Science and Engineering Online (CSE-Online): A Cyber-Infrastructure for Scientific Computing, <em><span style='font-family: "Arial","sans-serif"'>J. Chem. Info. Mod.</span></em>, 46, 971-984 (2006)<o:p></o:p></p> <p>F. Paesani, W. Zhang, D.A. Case, T. E. Cheatham, III, G. A. Voth, An Accurate and Simple Quantum Model for Liquid Water, <em><span style='font-family:"Arial","sans-serif"'>J. Chem. Phys.</span></em>, 125, 184507 (2006)<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=DavidGrainger6></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>David Grainger<o:p></o:p></span></u></b></p> <p>P. Wu, P. Hogrebe, D.W. Grainger, DNA and Protein Microarray Printing on Silicon Nitride Waveguide Surfaces, Biosens. Bioelectron</span></em> 21(7), 1252-1263 (2006). <o:p></o:p></p> <p>P. Wu, D.W. Grainger, Drug/Device Combinations for Local Drug Therapies and Infection Prophylaxis, Biomaterials</span></em> 27, 2450 (2006). <o:p></o:p></p> <p>R.J. Christie, D.J. Findley, M. Dunfee, R.D. Hansen, S.C. Olsen, D.W. Grainger, Photopolymerized Hydrogel Carriers for Live Vaccine Ballistic Delivery, Vaccine</span></em> 24, 1462 (2006). <o:p></o:p></p> <p>S.C. Olsen, R.J. Christie, D.W. Grainger, W.S. Stoffregen, Immunologic Responses of Bison to Vaccination with Brucella abortus strain RB51: Comparison of Parenteral to Ballistic Delivery via Compressed Pellets or Photopolymerized Hydrogels, Vaccine</span></em> 24, 1346-1353 (2006). <o:p></o:p></p> <p>P. Gong, G.M. Harbers, D.W. Grainger, Multi-technique Comparison of Immobilized and Hybridized Oligonucleotide Surface Density on Commercial Amine-Reactive Microarray Slides, Analy. Chem.</span></em> 78:7, 2342-2351 (2006). <o:p></o:p></p> <p>C-Y Lee, P. Gong, L.J. Gamble, D.G. Castner, D.W. Grainger, Hybridization Behavior of Mixed DNA/Alkylthiol Monolayers on Gold: Characterization by SPR and 32P Radiometric Assay, Analy. Chem.</span></em>, 78, 3316-3325 (2006). <o:p></o:p></p> <p>P. Gong, C-Y Lee, G.M. Harbers, D.G. Castner, D.W. Grainger, L.J. Gamble, Comparison of Immobilized DNA Orientation and Density Using NEXAFS, XPS, and Fluorescence Intensity Measurements on Gold, Analy. Chem.</span></em>, 78, 3326-3334 (2006) <o:p></o:p></p> <p>M.L. Godek, G.S. Malkov, E.R. Fisher, D.W. Grainger, Macrophage Serum-based Adhesion to Surface Chemistry is Distinct from that Exhibited by Fibroblasts, Plasma Proc. Polymers</span></em>, 3, 485-497, (2006). <o:p></o:p></p> <p>M.L. Godek, J.A. Sampson, N.L. Duchsherer, Q. McElwee, D.W. Grainger, Rho GTPase Protein Expression and Activation in Murine Monocyte/Macrophages is not Modulated by Model Biomaterial Biomaterial Culture Surfaces, J. Biomat. Sci. Polym. Ed.</span></em>, 17(10), 1141-1158 (2006). <o:p></o:p></p> <p>C-Y Lee, L.J. Gamble, D.W. Grainger, D.G. Castner, Mixed DNA/Oligoethylene Glycol Functionalized Gold Surfaces Improve DNA Hybridization in Complex Media, BioInterphases</span></em>, 1, 83-92 2006. <o:p></o:p></p> <p>D.W. Grainger, R. J. Christie, Delivery at a Distance: Degradable Ballistic Formulations for Vaccinating Wildlife, Controlled Release Society Newsletter</span></em>, September, 2005, p. 7. <o:p></o:p></p> <p>D.W. Grainger, AOs Biotechnology Advisory Board: Update on AO-sponsored research in biotechnology, AO Dialogue</span></em> (AO Foundation international newsletter), Vol. 1 (March) 2006. <o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><span style='font-size: 10.0pt;font-family:"Arial","sans-serif";color:black'><a href="file:///K:\Pharmaceutics\Nicoles%20Documents\website\stage\pharmaceutics\publications\index.html#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a></span><b><u><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></u></b></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>James Herron</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>J. N. Herron, S. E. Tolley, R. S. Smith, D. A. Christensen, Rapid Single Nucleotide Polymorphism Detection for Personalized Medicine Applications using Planar Waveguide Fluorescence Sensors. Proceedings SPIE</span></em>, Vol. 6080 (Advanced Biomedical and Clinical Diagnostic Systems IV), 60800Z (2006).<o:p></o:p></p> <p>J. N. Herron, D. A. Christensen, H.-K. Wang, K. D. Caldwell, V. Janatova, S.-C. Huang, Apparatus and Methods for MultiAnalyte Homogeneous Fluoroimmunoassays, U.S. Patent 6,979,567 (issued 12/27/05).<o:p></o:p></p> <p>J. N. Herron, D. A. Christensen, K. Caldwell, V. Janatova, S.-C. Huang, H.-K. Wang, Waveguide Immunosensor with Coating Chemistry and Providing Enhanced Sensitivity, U.S. Patent 7,022,515 (issued 4/04/06).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=WilliamHiguchi6></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>William Higuchi</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>G. Yan, S.K. Li, W.I. Higuchi, Evaluation of Constant Current Alternating Current Iontophoresis for Transdermal Drug Delivery, J. Controlled Rel.</span></em>, 110, 141-150 (2005).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=StevenKern6></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>Steven Kern</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>G.J. Noh, K.M. Kim, Y.B. Jeong, S.W. Jeong,H.S. Yoon, S.M. Jeong, S.H. Kang, O. Linares, S.E. Kern, Electroencephalographic Approximate Entropy Changes in Healthy Volunteers During Remifentanil Infusion, Anesthesiology</span></em>, 104, 921-932 (2006).<o:p></o:p></p> <p>M.L. Fidler, S.E. Kern, Flexible Interaction Model for Complex Interactions of Multiple Anesthetics, Anesthes.</span></em>,105, 286-296 (2006).<o:p></o:p></p> <p>K. Goteti, T. Masaki, T. Kuji, J.K. Leypoldt, A.K. Cheung, S.E. Kern, Perivascular Tissue Pharmacokinetics of Dipyridamole, Pharm. Res.</span></em> 23, 718-728 (2006).<o:p></o:p></p> <p>E. Witter, S.E. Kern, The Role of Morphines Metabolites in Analgesia:Concepts and Controversies, AAPS J.</span></em> 8, E348-E352 (2006).<o:p></o:p></p> <p>W. Zhu, Maskaki, A.K. Cheung, S.E. Kern, Cellular Pharmacokinetics and Pharmacodynamics of Dipyridamole in Vascular Smooth Muscle Cells, Biochem. Pharmacol.</span></em>, 72, 956-964 (2006).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=SungWanKim6></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>Sung Wan Kim</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>M. Lee, S. Oh, C.H. Ahn, S.W. Kim, B.D. Rhee, K.S. Ko, An Efficient GLP-1 Expression System Using Two-Step Transcription Amplification, J. Controlled Rel.</span></em>, 115, 316-321 (2006).<o:p></o:p></p> <p>S. Jo, J. Kim, S.W. Kim, Reverse Thermal Gelation of Aliphatically Modified Biodegradable Tri-block Copolymers, Macromolecular Rapid Comm.</span></em>, 6, 923-928 (2006).<o:p></o:p></p> <p>M. Lee, D. Choi, M. Choi, J.H. Jeong, W.J. Kim, S. Oh, Y.-H. Kim, D. Bull, S.W. Kim, Hypoxia-inducible Gene Expression System Using the Erythropoietin Enhancer and 3-untranslated Region for the VEGF Gene Therapy, J. Control. Rel.</span></em>, 115, 113-119 (2006).<o:p></o:p></p> <p>M.M. Janat-Amsbury, J.W. Yockman, M.L. Anderson, D.G. Kieback, S.W. Kim, Combination of Local, Non-viral IL-12 Gene Therapy and Systemic Paclitaxel Chemotherapy in an Syngeneic ID8 Mouse Model for Human Ovarian Cancer, Anticancer Res.</span></em>, 5A, 3223-3228 (2006).<o:p></o:p></p> <p>M.M. Janat-Amsbury, J.W. Yockman, M.L. Anderson, D.G. Kieback, S.W. Kim, Comparison of ID8 Mose and VEGF-modified ID8 Cell Lines in an Immunocompetent Animal Model for Human Ovarian Cancer, Anticancer Res.</span></em>, 26, 2785 (2006).<o:p></o:p></p> <p>W.J. Kim, J.W. Yockman, J.H. Jeong, L.V. Christensen, M. Lee, Y.H. Kim, S.W. Kim, Anti-angiogenic Inhibition of Tumor Growth by Systemic Delivery of PEI-g-PEG-RGD/pCMV-sFlt-1 Complexes in Tumor-bearing Mice, J. Control. Rel.</span></em>, 114, 381 (2006).<o:p></o:p></p> <p>L.V. Christensen, C-W. Chang, W.J. Kim, S.W. Kim, Reducible Poly(amido ethylenimine)s Designed for Triggered Intracellular Gene Delivery, Bioconj. Chem.</span></em>, 17, 1233 (2006).<o:p></o:p></p> <p>J.H. Park, M. Lee, S.W. Kim, Non-Viral Adiponectin Gene Therapy into Obese Type 2 Diabetic Mice Ameliorates Insulin Resistance, J. Control. Rel.</span></em>, 114, 118 (2006).<o:p></o:p></p> <p>W.J. Kim, L.V. Christensen, S.B. Jo, J.W. Yockman, J.H. Jeong, Y-H. Kim, S.W. Kim, Cholesteryl Oligoarginine Delivering Vascular Endothelial Growth Factor siRNA Effectively Inhibits Tumor Growth in Colon Adenocarcinoma, Mol. Ther.</span></em>, 14, 343 (2006).<o:p></o:p></p> <p>T.G. Park, J.H. Jeong, S.W. Kim, Current Status of Polymeric Gene Delivery Systems, Advanced Drug Delivery Reviews</span></em>, 58, 467 (2006).<o:p></o:p></p> <p>W.S. Shim, S.W. Kim, D.S. Lee, Sulfonamide-Based pH- and Temperature-Sensitive Biodegradable Block Copolymer Hydrogels, Biomacromolecules</span></em>, 7, 1935 (2006).<o:p></o:p></p> <p>W.S. Shim, S.W. Kim, E-K. Choi, H-J. Park, J-S. Kim, D.S. Lee, Novel pH Sensitive Block Copolymer Micelles for Solvent Free Drug Loading, Macromolecular Bioscience</span></em>, 6, 179 (2006).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=JindrichKopecek6></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>Jindrich Kopecek</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>J. Yang, C. Xu, C. Wang, J. Kopecek, Refolding Hydrogels Self-Assembled from HPMA Graft Copolymers by Antiparallel Coiled-Coil Formation, Biomacromolecules</span></em>, 7, 1187-1195 (2006). <o:p></o:p></p> <p>A. Malugin, P. Kopecková, J. Kopecek, HPMA Copolymer-Bound Doxorubicin Induces Apoptosis in Ovarian Carcinoma Cells by the Disruption of Mitochondrial Function, Molecular Pharmaceutics</span></em>, 3, 351-361 (2006). <o:p></o:p></p> <p>H. Pan, P. Kopecková, D. Wang, J. Yuan, S. Miller, J. Kopecek, Water-Soluble HPMA Copolymer Prostaglandin Conjugates Containing a Cathepsin K Sensitive Spacer, J. Drug Targeting</span></em>, 14, 425-435 (2006). <o:p></o:p></p> <p>J. Yang, C. Xu, P. Kopecková, J. Kopecek, Hybrid Hydrogels Self-Assembled from HPMA Copolymers Containing Peptide Grafts, Macromol. Biosci.</span></em>, 6, 201-209 (2006). <o:p></o:p></p> <p>J. Callahan, J. Kopecek, Semitelechelic HPMA Copolymers Functionalized with Triphenylphosphonium as Drug Carriers for Membrane Transduction and Mitochondrial Localization, Biomacromolecules</span></em>, 7, 2347-2356 (2006). <o:p></o:p></p> <p>H. Ding, W.M. Prodinger, J. Kopecek, Identification of CD21-Binding Peptides with Phage Display and Investigation of Binding Properties of HPMA Copolymer Peptide Conjugates, Bioconjugate Chem.</span></em>, 17, 514-523 (2006). <o:p></o:p></p> <p>H. Ding, W.M. Prodinger, J. Kopecek, Two-Step Fluorescence Screening of CD21-Binding Peptides with One-Bead One-Compound Library and Investigation of Binding Properties of HPMA Copolymer-Peptide Conjugates, Biomacromolecules</span></em>, 7, 3037-3046 (2006). <o:p></o:p></p> <p>M. Oman, J. Liu, J. Chen, D. Durrant, H.-S. Yang, Y. He, P. Kopecková, J. Kopecek, R.M. Lee, Using N-(2-Hydroxypropyl)methacrylamide Copolymer Drug Bioconjugate as a Novel Approach to Deliver a Bcl-2-Targeting Compound HA14-1 In Vivo, Gene Ther. Mol. Biol.</span></em> 10, 113-122 (2006). <o:p></o:p></p> V. Cuchelkar, J. Kopecek, Polymer-Drug Conjugates, Polymers in Drug Delivery</span></em>, I.F. Uchegbu, A.G. Sch</span><span style='font-size:10.0pt;color:black'>:M</span><span style='font-size:10.0pt;font-family:"Arial","sans-serif";color:black'>lein, Eds., CRC Press, Boca Raton, Florida, 155-182 (2006). <o:p></o:p></span></p> <p>D. Wang, M. Sima, R.L. Mosley, J.P. Davda, N. Tietze, S.C. Miller, P.R. Gwilt, P. Kopecková, J. Kopecek, Pharmacokinetic and Biodistribution Studies of a Bone-targeting Drug Delivery System Based on N-(2-Hydroxypropyl)methacrylamide (HPMA) Copolymers, Molecular Pharmaceutics</span></em>, 3, 717 (2006). <o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=CarolLim6></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>Carol Lim</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>J.R. Davis, M. Kakar, C.S. Lim, Controlling Protein Compartmentalization to Overcome Disease, Pharmaceutical Research</span></em>, 2006, Sep 13; [Epub ahead of print].<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=ZhengRongLu6></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>Zheng-Rong Lu</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>Z.-R. Lu, A.M. Mohs, Y. Zong, Y. Feng, Polydisulfide Gd(III) Chelates as Biodegradable Macromolecular Magnetic Resonance Imaging Contrast Agents, Intl. J. Nanomed.</span></em>, 1, 31-40 (2006).<o:p></o:p></p> <p>S.Q. Gao, Z.R. Lu, B. Petri, P. Kopeckova, J. Kopecek, Colon-specific 9-aminocamptothecin-HPMA Copolymer Conjugates Containing a 1,6-elimination spacer, J. Control. Release</span></em>, 110, 323-331 (2006).<o:p></o:p></p> <p>T. Kaneshiro, T. Ke, EK Jeong, D.L. Parker, Z.-R. Lu, (Gd-DTPA)-(L-cystine bisalkylamide) Copolymers as Novel Biodegradable Macromolecular Contrast Agents for MR Blood Pool Imaging, Pharm. Res.</span></em>, 23, 1285-1294 (2006).<o:p></o:p></p> <p>Y. Zong, T. Ke, A.M. Mohs, J. Guo, D.L. Parker, Z.-R. Lu, Effect of Size and Charge on in vivo MRI Contrast Enhancement of Polydisulfide Gd(III) Complexes, J. Control. Release</span></em>, 112, 350-356 (2006).<o:p></o:p></p> <p>Y. Feng, Y. Zong, T. Ke, Z.-R. Lu, Pharmacokinetics and Blood Pool Contrast Enhancement of Gd-DTPA Cystine Copolymers and Gd-DTPA Cystine Diethyl Ester Copolymers, Pharm. Res.</span></em>, 23, 1736-1742 (2006).<o:p></o:p></p> <p>T. Ke, Y. Feng, J. Guo, D. L. Parker, Z.-R. Lu, Biodegradable Cystamine Spacer Facilitates the Clearance of Gd(III) Chelates in Poly(glutamic acid) Gd-DOTA Conjugates for Contrast Enhanced MR Imaging, MRI</span></em>, 24, 931-940 (2006).<o:p></o:p></p> <p>A. Vaidya, Y. Sun, T. Ke, E.K. Jeong, Z.-R. Lu, MRI Guided Photodynamic Therapy for Specific Cancer Treatment, MRM</span></em>, 56, 761-767 (2006).<o:p></o:p></p> <p>Z.-R. Lu, What Can You See with Imaging in Pharmaceutical Research? Mol. Pharm.</span></em>, 3, 471 (2006).<o:p></o:p></p> <p>T. D. Nguyen, P. Spincemaille, A. Vaidya, M. R. Prince, Z.-R. Lu, Y. Wang, Biodegradable Intravascular (Gd-DTPA)-cystamine Copolymer for Contrast-enhanced Steady-state Free Precession Magnetic Resonance Angiography: Comparison with MS-325 in a Swine Model, Mol. Pharm.</span></em>, 3, 558-565 (2006).<o:p></o:p></p> <p>F. Ye, T. Ke, E.-K. Jeong, M. Johnson, Z.-R. Lu, Visualization of Size Effect of Poly(L-glutamic acid) in Drug Delivery with Contrast Enhanced MR Imaging, Mol. Pharm.</span></em>, 3, 507-515 (2006).<o:p></o:p></p> <p>Z.-R. Lu, Y. Wang, F. Ye, A. Vaidya, E.-K. Jeong, Paramagnetic Polymer Conjugates for Non-invasive Evaluation of in vivo Drug Delivery, Nanotechnology for Cancer Therapy</span></em>, M.M. Amiji, Ed., Taylor and Francis Group, LLC, Boca Raton, FL, 2006.<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <o:p></o:p></p> <p class=deptname>2005 Publications:<a name=2005Publications1></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><a name=YouHanBae5></a><b><u><span style='font-family:"Arial","sans-serif";color:black'>You Han Bae</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>J.-H. Kim, Y.H. Bae, Albumin Loaded Microsphere of Amphiphilic Poly(ethylene glycol)/aliphatic poly(ester) Multiblock Copolymer, Eur. J. Pharm. Sci.</span></em>, 23, 245-251 (2004).<o:p></o:p></p> <p>S. Kim, S.W. Kim, Y.H. Bae, Synthesis, Bioactivity, and Specificity of Glucagons-like Peptide-1/polymer Conjugate, Biomaterials</span></em>, 26, 3597-3606 (2005).<o:p></o:p></p> <p>E.S. Lee, K. Na, Y.H. Bae, Ultra pH-sensitive Multifunctional Polymeric Micelles, Nano Lett.</span></em>, 5, 325-329 (2005).<o:p></o:p></p> <p>E.S. Lee, K. Na, Y.H. Bae, Doxorubicin Loaded Smart Polymeric Micelles for Reversal of Resistant MCF-7 Tumor, J. Control. Release</span></em>, 103, 405-418 (2005).<o:p></o:p></p> <p>M.I. Whang, J.M. Suh, Y.H. Bae, S.W. Kim, B. Jeong, Caprolactonic Poloxamer Analogue, PEG-PCL-PEG, Biomacromolecules</span></em>, 6, 885-890 (2005).<o:p></o:p></p> <p>H.C. Kang, S. Kim, M. Lee, Y.H. Bae, Polymeric Gene Carrier for Insulin Secreting Cells: Poly(L-lysine)-g-sulfonylurea for Receptor Mediated Transfection, J. Control. Release</span></em>, 105, 164-176 (2005).<o:p></o:p></p> <p>B. Jeong, S.J. Bae, J.M. Suh, Y.H. Bae, S.W. Kim, Thermogelling Poly(caprolactone-b-ethylene glycol-b-caprolactone) Aqueous Solution, Macromolecues</span></em>, 38, 5260-5265 (2005).<o:p></o:p></p> <p>W.J. Sung, Y.H. Bae, Glucose Oxidase, Lactate Oxidase, and Galactose Oxidase Enzyme Electrode Based on Polypyrrole with Polyanion/PEG/enzyme Conjugate Dopant, Sensors and Actuators. B. Chemical</span></em> (in press).<o:p></o:p></p> <p>Y.Y. Kim, S.Y. Chae, S. Kim, Y.R. Byun, Y.H. Bae, Improved Phenotype of Macroencapsulated Rat Islets by Co-encapsulation with Cross-linked Hb, J. Biomater. Sci. Polym. Ed.</span></em> (submitted 09/15/04, revised 03/01/05, accepted 05/13/05, in press).<o:p></o:p></p> <p>W.S. Shim, J.S. Yoo, Y.H. Bae, D.S. Lee, Novel Injectable pH and Temperature Sensitive Block Copolymer Hydrogel, Biomacromolecules</span></em>, 6, 2930-2934 (2005).<o:p></o:p></p> <p>Z.G. Gao, D.H. Lee, D.I. Kim, Y.H. Bae, Doxorubicin Loaded pH-sensitive Micelle Targeting Acidic Extracellular pH of Human Ovarian A2780 Tumor in Mice, J. Drug Target.</span></em>, 13, 391-397 (2005).<o:p></o:p></p> <p>J.-H. Kim, A. Taluja, K. Knutson, Y.H. Bae, Stability of Bovine Serum Albumin Complexed with PEG-poly(L-histidine) Diblock Copolymer in PLGA Microspheres, J. Control. Release</span></em>, 109, 86-100 (2005).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=ThomasCheatham5></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>Thomas Cheatham</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>T.E. Cheatham, III, Molecular Modeling and Atomistic Simulation of Nucleic Acids, in Annual Reports in Computational Chemistry</span></em>, Edited by D. Spellmeyer., Elsevier Press, Vol. 1, pp. 75-89 (2005).<o:p></o:p></p> <p>D. A. Case, T.E. Cheatham, III, T.A. Darden, H. Gohlke, R. Luo, K. M. Merz, Jr., A. Onufriev, C. Simmerling, B. Wang, R. Woods, The AMBER Biomolecular Simulation Programs, J. Comp. Chem.</span></em>, 26, 1668-1688 (2005).<o:p></o:p></p> <p>T.E. Cheatham, III, D.A. Case, Applying AMBER Biomolecular Simulation Methods to DNA and RNA: Insight into the Dynamics, Interactions and Energetics of Varied Nucleic Acid Structures, in Computational Studies of DNA and RNA</span></em>, Edited by J. Sponer, Wiley Press, (in press) (2006).<o:p></o:p></p> <p>S.B. Dixit, D.L. Beveridge, D.A. Case, T.E. Cheatham III, E. Giudice, F. Lankas, R. Lavery, J. Maddocks, R. Osman, H. Sklenar, K.M. Thayer, P. Varnai, Molecular Dynamics Simulations of the 136 Unique Tetranucleotide Sequences of DNA Oligonucleotides. II. Sequence Context Effects on the Dynamical Structures of the 10 Unique Dinucleotide Steps, Biophys. J.</span></em>, 89, 3721-3740 (2005).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=JamesHerron5></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>James Herron</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>W. Jiskoot, A.J.W.G. Visser, J.N. Herron, M. Sutter, Fluorescence Spectroscopy, in Methods for Structural Analysis of Protein Pharmaceuticals</span></em>, Edited by W. Jiskoot and D. Crommelin, AAPS Press, Arlington, VA, pp. 27-82 (2005).<o:p></o:p></p> <p>J.N. Herron, H.-K. Wang, L. Tan, S.Z. Brown, A.H. Terry, J.D. Durtschi, S.E. Tolley, E.M. Simon, M.E. Astill, R.S. Smith, D.A. Christensen, Planar Waveguide Biosensors for Point-Of-Care Clinical and Molecular Diagnostics, in Fluorescence Sensors and Biosensors</span></em>, Edited by R.B. Thompson, Taylor &amp; Francis CRC Press, New York, pp. 283-332 (2005).<o:p></o:p></p> <p>W.M. Reichert, J.N. Herron, D.A. Christensen, H.-K. Wang, J. D. Durtschi, Composite Waveguide for Solid Phase Binding Assays, U.S. Patent 6,911,344 (issued on 6/28/05).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=WilliamHiguchi5></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>William Higuchi</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>W.M. Reichert, J.N. Herron, D.A. Christensen, H.-K. Wang, J. D. Durtschi, Composite Waveguide for Solid Phase Binding Assays, U.S. Patent 6,911,344 (issued on 6/28/05).<o:p></o:p></p> <p>G. Yan, K.D. Peck, H. Zhu, W.I. Higuchi, S.K. Li, Effects of Electrophoresis and Electroosmosis during Alternating Current Iontophoresis across Human Epidermal Membrane, J. Pharm. Sci.</span></em>, 94, 547-558 (2005).<o:p></o:p></p> <p>N. He, K.S. Warner, W.I. Higuchi, S.K. Li, Model Analysis of Flux Enhancement Across Hairless Mouse Skin Induced by Chemical Permeation Enhancers, Int. J. Pharm.</span></em>, 297, 9-21 (2005).<o:p></o:p></p> <p>S.K. Li, Y. Zhang, H. Zhu, W.I. Higuchi, H.S. White, Influence of Asymmetric Donor-Receiver Ion Concentration upon Transcleral Iontophoretic Transport, J. Pharm. Sci.</span></em>, 94, 847-860 (2005).<o:p></o:p></p> <p>D.D. Heslop, Y. Bi, A.A. Baig, M. Otsuka, W.I. Higuchi, A Comparative Study of the Metastable Equilibrium Solubility Behavior of Low-Crystallinity and High-Crystallinity Carbonated Apatites using pH and Solution Strontium as Independent Variables, J. Colloid Interface Sci.</span></em>, 289, 14-25 (2005).<o:p></o:p></p> <p>S. K. Li, W.I. Higuchi, Mechanistic Studies of Permeation Enhancers, in Percutaneous Penetration Enhancers</span></em>, Edited by E.W. Smith and H.I. Maibach, CRC Press, Inc., Boca Raton, FL (2005).<o:p></o:p></p> <p>S. K. Li, W.I. Higuchi, Quantitative Structure-Enhancement Relationships and the Microenvironment of the Enhancer Site of Action, in Percutaneous Penetration Enhancers</span></em>, Edited by E.W. Smith and H.I. Maibach, CRC Press, Inc., Boca Raton, FL (2005).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=StevenKern5></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>Steven Kern</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>R.A. Lugo, S.E. Kern, The Pharmacokinetics of Oxycodone, J. Pain Palliat. Care Pharmacother.</span></em>, 18, 17-30 (2004).<o:p></o:p></p> <p>T. Masaki, R. Rathi, G. Zentner, J.K. Leypoldt, S.F. Mohammad, G.L. Burns, L. Li, S. Zhuplatov, T. Chirananthavat, S.J. Kim, S. Kern, J. Holman, S.W. Kim, A.K. Cheung, Inhibition of Neointimal Hyperplasia in Vascular Grafts by Sustained Perivascular Delivery of Paclitaxel, Kidney Int.</span></em>, 66, 2061-2069 (2004).<o:p></o:p></p> <p>M. Bikram, M. Lee, C.W. Chang, M.M. Janat-Amsbury, S.E. Kern, S.W. Kim, Long-circulating DNA-complexed Biodegradable Multiblock Copolymers for Gene Delivery: Degradation Profiles and Evidence of Dysopsonization, J. Control. Release</span></em>, 103(1), 221-233 (2005).<o:p></o:p></p> <p>S.R. Arain, S. Kern, D.J. Ficke, T.J. Ebert, Variability of Duration of Action of Neuromuscular-blocking Drugs in Elderly Patients, Acta Anaesthesiol. Scand.</span></em>, 49(3), 312-315 (2005).<o:p></o:p></p> <p>M.M. Janat-Amsbury, J.W. Yockman, M. Lee, S. Kern, D.Y. Furgeson, M. Bikram, S.W. Kim, Local, Non-viral IL-12 Gene Therapy Using a Water Soluble Lipopolymer as Carrier System Combined with Systemic Paclitaxel for Cancer Treatment, J. Control. Release</span></em>, 101(1-3), 273-285 (2005).<o:p></o:p></p> <p>S. Sikharam, T.D. Egan, S.E. Kern, Cyclodextrins as New Formulation Entities and Therapeutic Agents, Curr. Opin. Anaesthesiol.</span></em>, 18, 392-395 (2005).<o:p></o:p></p> <p>P.A. Murphy, S.E. Kern, F.Z. Stanczyk, C.L. Westfoff, Interaction of St. John's Wort with Oral Contraceptives: Effects on the Pharmacokinetics of Norethindrone and Ethinyl Estradiol, Ovarian Activity and Breakthrough Bleeding, Contraception</span></em>, 71, 402-408 (2005).<o:p></o:p></p> <p>S.E. Kern, D. Jaron, Complementary and Alternative Medicine in the Technology Age. Applying Bioengineering to Understand and Evaluate the Efficacy of Age-old Remedies, IEEE Eng. Med. Biol. Mag.</span></em>, 24, 28-29 (2005).<o:p></o:p></p> <p>W. Zhu, T. Masaki, Y.H. Bae, R. Rathi, A.K. Cheung, S.E. Kern, Development of a Sustained-release System for Perivascular Delivery of Dipyridamole, J. Biomed. Mater. Res. B Appl. Biomater.</span></em>, in press (2005).<o:p></o:p></p> <p>R.A. Lugo, K.L. Satterfield, S.E. Kern, The Pharmacokinetics of Methadone, J. Pain Palliat. Care Pharmacother.</span></em> in press (2005).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=SungWanKim5></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>Sung Wan Kim</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>S. Choi, S. Oh, M. Lee, S.W. Kim, Glucagon-Like Peptide-1 Plasmid Construction and Delivery for the Treatment of Type 2 Diabetes, Molecular Therapy</span></em>, 12, 885-891 (2005).<o:p></o:p></p> <p>J.H. Jeong, S. H. Kim, S.W. Kim, T.G. Park, In Vivo Tumor Targeting of ODN-PEG-Folic Acid/PEI Polyelectrolyte Complex Micelles, J. Biomater. Sci. Polym. Ed.</span></em>, 16, 1409-1420 (2005).<o:p></o:p></p> <p>J.H. Jeong, M. Lee, W.J. Kim, J.W. Yockman, T.G. Park, Y.H. Kim, S.W. Kim, Anti-GAD Antibody Targeted Non-Viral Gene Delivery to Islet Beta Cells, J. Control. Release</span></em>, 107, 562-570 (2005).<o:p></o:p></p> <p>W.J. Kim, J.W. Yockman, M. Lee, J.H. Jeong, Y.-H. Kim, S.W. Kim, Soluble Flt-1 Gene Delivery Using PEI-g-PEG-RGD Conjugate for Anti-angiogenesis, J. Control. Release</span></em>, 106, 224-234 (2005).<o:p></o:p></p> <p>M. Lee, J.-K. Ryu, S.-M. Oh, E. Lee, H.-Y. Shin, S.U. Song, S.W. Kim, J.-K. Suh, Water Soluble Lipopolymer as a Gene Carrier to Corpus Cavernosum, Int. J. Impotence Res.</span></em>, 17, 326-334 (2005).<o:p></o:p></p> <p>J.H. Jeong, S.H. Kim, S.W. Kim, T.G. Park, Polyelectrolyte Complex Micelles Composed of c-raf Antisense Oligodeoxynucleotide-Poly(ethylenimine): Effect of Systemic Administration on Tumor Growth, Bioconjugate Chem.</span></em>, 16, 1034-1037 (2005).<o:p></o:p></p> <p>S.H. Kim, J.H. Jeong, K.C. Cho, S.W. Kim, T.G. Park, Target-Specific Gene Silencing by siRNA Plasmid DNA Complexed with Folate-Modified Poly(ethylenimine), J. Control. Release</span></em>, 104, 223-232 (2005).<o:p></o:p></p> <p>J.J. Hwang, J.M. Suh, Y.H. Bae, S.W. Kim, B. Jeong, Caprolactonic Poloxamer Analog: PEG-PCL-PEG, Biomacromolecules</span></em>, 6, 885-890 (2005).<o:p></o:p></p> <p>S.J. Bae, J.Y. Suh, Y.S. Sohn, Y.H. Bae, S.W. Kim, B. Jeong, Thermogelling Poly(caprolactone-b-ethylene glycol-b-caprolactone) Aqueous Solutions, Macromolecules</span></em>, 38, 5260-5265 (2005).<o:p></o:p></p> <p>M. Bikram, M. Lee C.-W. Chang, M.-M.J. Amsbury, S.E. Kern, S.W. Kim, Long-Circulating DNA-Complexed Biodegradable Multiblock Copolymers for Gene Delivery: Degradation Profiles and Evidence of Dysopsonization, J. Control. Release</span></em>, 103, 221-233 (2005).<o:p></o:p></p> <p>Y.H. Kim, J.H. Park, M. Lee, Y.H. Kim, T.G. Park, S.W. Kim, Polyethylenimine with Acid-Labile Linkages as a Biodegradable Gene Carrier, J. Control. Release</span></em>, 103, 209-219 (2005).<o:p></o:p></p> <p>S. Kim, S.W. Kim, Y.H. Bae, Synthesis, Bioactivity and Specificity of Glucagons-Like Peptide-1 (7-37/Polymer Conjugate to Isolated Rat Islets, Biomaterials</span></em>, 26, 3597-3606 (2005).<o:p></o:p></p> <p>Y. Yi, J.H. Kim, H-W. Kang, H.S. Oh, S.W. Kim, M. H. Seo, A Polymeric Nanoparticle Consisting of mPEG-PLA-Toco and PLMA-COONa as a drug Carrier: Improvements in Cellular Uptake and Biodistribution, Pharm. Res.</span></em>, 22, 200-208 (2005).<o:p></o:p></p> <p>M. Lee, S.W. Kim, Polyethylene Glycol Conjugated Copolymers for Plasmid DNA Delivery, Pharm. Res.</span></em>, 22, 1-11 (2005).<o:p></o:p></p> <p>M.M. Janat, J.W. Yockman, M. Lee, S. Kern, D.Y. Furgeson, M. Bikram, S.W. Kim, Local, Non-viral IL-12 Gene Therapy Using a Water Soluble Lipopolymer as Carrier System Combined with Systemic Paclitaxel for Cancer Treatment, J. Control. Release</span></em>, 101, 273-285 (2005).<o:p></o:p></p> <p>K.C. Cho, J.H. Jeong, H.J. Chung, C.O. Jeo, S.W. Kim, T.W. Park, Folate Receptor-Mediated Intracellular Delivery of Recombinant Caspase-3 for Inducing Apoptosis, J. Control. Release</span></em>, 108, 121-131 (2005).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=JindrichKopecek5></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>JindYich Kope ek</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>C. Xu, V. Breedveld, J. Kope ek, Reversible Hydrogels from Self-Assembling Genetically Engineered Protein Block Copolymers, Biomacromolecules</span></em>, 6, 1739-1749 (2005).<o:p></o:p></p> <p>A. Nori, J. Kope ek, Intracellular Targeting of Polymer-Bound Drugs for Cancer Chemotherapy, Adv. Drug Delivery Rev.</span></em>, 57, 609-636 (2005).<o:p></o:p></p> <p>T. Merdan, K. Kunath, H. Petersen, U. Bakowsky, K.H. Voigt, J. Kope ek, T. Kissel, PEGylation of Poly(ethylene imine) Affects Stability of Complexes with Plasmid DNA Under In Vivo Conditions in a Dose-Dependent Manner after Intravenous Injection into Mice, Bioconjugate Chem.</span></em>, 16, 785-792 (2005).<o:p></o:p></p> <p>S.C. Miller, D. Wang, P. Kope ková, J. Kope ek, Biopolymer-Based Delivery System for Advanced Imaging and Skeletal Tissue-Specific Therapeutics, J. Bone Miner. Metab.</span></em>, 23(suppl), 103-108 (2005).<o:p></o:p></p> <p>D. Wang, S. Miller, P. Kope ková, J. Kope ek, Bone-Targeting Macromolecular Therapeutics, Adv. Drug Delivery Rev.</span></em>, 57, 1049-1076 (2005).<o:p></o:p></p> <p>P. Chivukula, K. Dusek, D. Wang, M. Duskova-Smrckova, P. Kope ková, J. Kope ek, Synthesis and Characterization of Novel Aromatic Azo Bond-Containing pH-Sensitive and Hydrolytically Cleavable IPN Hydrogels, Biomaterials</span></em>, 27, 1140-1151 (2006).<o:p></o:p></p> <p>S. Gao, Z.-R. Lu, B. Petri, P. Kope ková, J. Kope ek, Colon-specific 9-Aminocamptothecin-HPMA Copolymer Conjugates Containing a 1,6-Elimination Spacer, J. Control. Release</span></em>, 110, 323-331 (2006).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=CarolLim5></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>Carol Lim</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>H. Li, M.L. Fidler, C.S Lim, Effect of Initial Subcellular Localization of Progesterone Receptor on Import Kinetics and Transcriptional Activity, Molecular Pharmaceutics</span></em>, in press,(2005).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=ZhengRongLu5></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>Zheng-Rong Lu</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>Z.-R. Lu, Stability of Proteins and Nucleic Acids, Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids</span></em>, R. I. Mahato, Ed., CRC Press, New York, NY, 352-377 (2005).<o:p></o:p></p> <p>Y. Zong, X. Wang, K. C. Goodrich, A.M. Mohs, D. L. Parker, Z.-R. Lu, Contrast Enhanced Tumor MRI with New Biodegradable Macromolecular Gd(III) Complexes in Mice, Magn. Reson. Med.</span></em>, 53, 835-842 (2005).<o:p></o:p></p> <p>X. Wang, H.Y. Feng, T. Ke, M. Schable, Z.-R. Lu, Pharmacokinetics and Long-term Gd Tissue Accumulation of (Gd-DTPA)-cystamine Copolymers, a Biodegradable Macromolecular MRI Contrast Agent, Pharm. Res.</span></em>, 22, 596-601 (2005).<o:p></o:p></p> <p>A.M. Mohs, Y. Zong, J. Guo, D. L. Parker, and Z.-R. Lu, PEG-g-Poly(GdDTPA-co-L-cystine): Effect of PEG Chain Length on in vivo Contrast Enhancement in MRI, Biomacromolecules</span></em>, 6, 2305-2311 (2005).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <o:p></o:p></p> <p class=deptname>2004 Publications:<a name=2004Publications1></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><a name=YouHanBae4></a><b><u><span style='font-family:"Arial","sans-serif";color:black'>You Han Bae</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>S.I. Kang, K, Na, Y.H. Bae, Physicochemical Characteristics and Doxorubicin-release Behaviors of pH/temperature Sensitive Nanoparticles, Colloids and Surfaces A: Physicochem. Eng. Aspects</span></em>, 231, 103-112 (2003).<o:p></o:p></p> <p>S.Y. Chae, M. Lee, S.W. Kim, Y.H. Bae, Protection of Insulin Secreting Cells from Nitric Oxide Induced Cellular Damage by Incorporation of Cross-linked Hemoglobin, Biomaterials</span></em>, 25(5), 843-850 (2004).<o:p></o:p></p> <p>J.W. Yi, K. Na, Y.H. Bae, Ionic Strength/temperature-induced Gelation of Aqueous Poly(N-isopropylacrylamide-co-vinylimidazole) Solution, Macromol. Symp.</span></em>, 207, 131-137 (2004).<o:p></o:p></p> <p>K. Na, K.H. Lee, Y.H. Bae, pH-Sensitivity and pH-dependent Interior Structural Change of Self-assembled Hydrogel Nanoparticles of Pullulan Acetate/oligosulfonamide Conjugate, J. Control. Release</span></em>, 97, 513-525 (2004).<o:p></o:p></p> <p>C.-H. Ahn, S.Y. Chae, Y.H. Bae, S.W. Kim, Synthesis of Biodegradable Multi-block Copolymers of Poly(L-lysine) and Poly(ethylene glycol) as a Non-viral Gene Carrier, J. Control. Release</span></em>, 97, 567-574 (2004).<o:p></o:p></p> <p>W.J. Sung, K. Na and Y.H. Bae, Biocompatibility and Interference Eliminating Property of Pullulan Acetate/PEG/heparin Membrane for the Outer Layer of an Amperometric Glucose Sensor, Sensors and Actuators. B. Chemical</span></em>, 99, 393-398 (2004).<o:p></o:p></p> <p>E.S. Lee, J.H. Park, G. Wallace, Y.H. Bae, In situ Formed Processable Polypyrrole Nanoparticles/amphiphilic Elastomer Composites and Their Properties, Polym. Intern.</span></em>, 53, 400-405 (2004).<o:p></o:p></p> <p>Y.H. Bae, Caged Pancreatic Islet for IDDM (a short review), Yonsei Medical J.</span></em>, 45 (Suppl), 56-60 (2004).<o:p></o:p></p> <p>S.Y. Chae, Y.Y. Kim, S.W. Kim, Y.H. Bae, Prolonged Glucose Normalization of Streptozotocin-induced Diabetic Mice by Transplantation of Rat Islets Co-encapsulated with Crosslinked Hemoglobin, Transplantation</span></em>, 78, 392-397 (2004).<o:p></o:p></p> <p>S.I. Kang, Y.H. Bae, pH-Dependent Elution Profiles of Selected Proteins in HPLC Having Stationaly Phase Modified with pH-sensitive Sulfonamide Polymers, J. Biomater. Sci. Polym. Ed.</span></em>, 15(7), 879-894 (2004).<o:p></o:p></p> <p>S. Kim, S.W. Kim, Y.H. Bae,  Long-term Insulinotropic Activity of Glucagon-like Peptide-1/polymer Conjugate on Islet Microcapsules, Tissue Eng.</span></em>, 10, 1607-1616 (2004).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=ThomasCheatham4></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>Thomas Cheatham</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>R. Stefl, T. E. Cheatham, III, N. `pa ková, E. Fadrna, I. Berger, J. Koca, J. Sponer, Folding Pathways of a Guanine-quadruplex DNA Revealed by Molecular Dynamics and Thermodynamical Analysis of the Substates, Biophys. J.</span></em>, 85, 1787-1804 (2003).<o:p></o:p></p> <p>F. Lankas, J. Sponer, J. Langowski, T. E. Cheatham, III, DNA Base-pair Step Deformability Inferred from Molecular Dynamics Simulation, Biophys. J.</span></em>, 85, 2872-2883 (2003).<o:p></o:p></p> <p>F. Lankas, J. Sponer, J. Langowski, T. E. Cheatham, III, DNA Deformability at the Base Pair Step, , 126, 4124-4125 (2004).<o:p></o:p></p> <p>E. Fadrna, N. `pa ková, R. Stefl, J. Koca, T.E. Cheatham, III, J. Sponer,  Molecular Dynamics Simulations of Guanine Quadruplex Loops: Advances and Force Field Limitations, <em><span style='font-family:"Arial","sans-serif"'>Biophys. J.</span></em>, 85, 2872-2883 (2004).<o:p></o:p></p> <p>T.E. Cheatham, III,  Simulation and Modeling of Nucleic Acid Structure, Dynamics and Interactions, <em><span style='font-family:"Arial","sans-serif"'>Curr. Opin. Struct. Biol.</span></em>, 14, 360-367 (2004).<o:p></o:p></p> <p>D.L. Beveridge, G. Barreiro, K.S. Byun, D.A. Case, T.E. Cheatham III, S.B. Dixit, E. Giudice, F. Lankas, R. Lavery, J. Maddocks, R. Osman, E. Seibert, H. Sklenar, G. Stoll, K.M. Thayer, P. Varnai, M.A. Young,  Molecular Dynamics Simulations of the 136 Unique Tetranucleotide Sequences of DNA Oligonucleotides. I. Research Design, Informatics, and Results on d(CpG) Steps, <em><span style='font-family:"Arial","sans-serif"'>Biophys. J.</span></em>, 87, 3799-3813 (2004).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=JamesHerron4></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>James Herron</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>S. Terzyan, P.A. Ramsland, E.W. Voss, Fr., J.N. Herron, A.B. Edmundson,  Three-dimensional Structures of Idiotypically Related Fabs with Intermediate and High Affinity for Fluorescein, <em><span style='font-family:"Arial","sans-serif"'>J. Mol. Biology</span></em>, 339, 1141-1151 (2004).<o:p></o:p></p> <p>J.S. Cavenaugh, H.-K. Wang, J. Sha, C. Hansen, K. Papangkorn, R.S. Smith, J.N. Herron,  An Investigation into How Well an Idiotope Peptide Mimic Can Replace its Parent Idiotype, <em><span style='font-family:"Arial","sans-serif"'>Pharm. Res.</span></em>, 21, 1480-1488 (2004).<o:p></o:p></p> <p>Y. Liu, J. Bishop, L. Williams, S. Blair, J. Herron,  Biosensing Based upon Molecular Confinement in Metallic Nanocavity Arrays, <em><span style='font-family:"Arial","sans-serif"'>Nanotechnology</span></em>, 15, 1368-1374 (2004).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=WilliamHiguchi4></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>William Higuchi</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>S.K. Li, W.I. Higuchi, H. Zhu, S.E. Kern, D.J. Miller, M.S. Hastings,  In Vitro and In Vivo Comparisons of Constant Resistance AC Iontophoresis and DC Iontophoresis, <em><span style='font-family:"Arial","sans-serif"'>J. Control. Release</span></em>, 91, 327-344 (2003).<o:p></o:p></p> <p>D.D. Heslop, Y. Bi, A.A. Baig, W.I. Higuchi,  Metastable Equilibrium Solubility Behavior of Carbonated Apatite in the Presence of Solution Strontium, <em><span style='font-family:"Arial","sans-serif"'>Calcif. Tissue Int.</span></em>, 74, 72-85 (2004).<o:p></o:p></p> <p>D. Chantasart, S.K. Li, N. He, K.S. Warner, S. Prakongpan, W. I. Higuchi,  Mechanistic Studies of Branched Chain Alkanols as Skin Permeation Enhancers, <em><span style='font-family:"Arial","sans-serif"'>J. Pharm. Sci.</span></em>, 93, 762-779 (2004).<o:p></o:p></p> <p>S.K. Li, W.I. Higuchi, R.P. Kochambilli, H. Zhu,  Mechanistic Studies of Flux Variability of Neutral and Ionic Permeants during Constant Current DC Iontophoresis with Human Epidermal Membrane, <em><span style='font-family: "Arial","sans-serif"'>Int. J. Pharm.</span></em>, 273, 9-22 (2004).<o:p></o:p></p> <p>N. He, K.S. Warner, D. Chantasart, D.S. Shaker, W.I. Higuchi S.K. Li,  Mechanistic Study of Chemical Skin Permeation Enhancers with Different Polar and Lipophilic Functional Groups, <em><span style='font-family:"Arial","sans-serif"'>J. Pharm. Sci.</span></em>, 93., 1415-1430 (2004).<o:p></o:p></p> <p>M. Otsuka, Y. Ohshita, S. Marunaka, Y. Matsuda, A. Ito, N. Ichinose, K. Otsuka, W.I. Higuchi,  Effect of Controlled Zinc Release on Bone Mineral Density from Injectable Zn-Containing -Tricalcium Phosphate Suspension in Zinc-Deficient Diseased Rats, <em><span style='font-family:"Arial","sans-serif"'>J. Biomed. Mater. Res.</span></em>, 69A, 552-560 (2004).<o:p></o:p></p> <p>G. Yan, W.I. Higuchi, A. Szabo, S.K. Li,  Correlation of Transdermal Iontophoretic Phenylalanine and Mannitol Transport: Test of the Internal Standard Concept Under DC Iontophoresis and Constant Resistance AC Iontophoresis Conditions, <em><span style='font-family:"Arial","sans-serif"'>J. Control. Release</span></em>, 98, 127-138 (2004).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=StevenKern4></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>Steven Kern</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>T.D. Egan, S.E. Kern, K.T. Muir, J. White,  Remifentanil by Bolus Injection: A Safety, Pharmacokinetic, Pharmacodynamic, and Age Effect Investigation in Human Volunteers, <em><span style='font-family:"Arial","sans-serif"'>Br. J. Anaesth.</span></em>, 92, 335-343 (2004).<o:p></o:p></p> <p>S.E. Kern, G. Xie, J.L. White, T.D. Egan,  Opioid-hypnotic Pharmacodynamic Synergy: A Response Surface Analysis of Propofol-remifentanil Pharmadodynamic Interactions in Volunteers, <em><span style='font-family:"Arial","sans-serif"'>Anesthesiology</span></em>, 100, 1373-81 (2004).<o:p></o:p></p> <p>A. Ratka, E. Wittwer, L. Baker, S. Kern,  Pharmacokinetics of Morphine, Morphine-3-glucuronide, and Morphine-6-glucurominde in Healthy Older Men and Women, <em><span style='font-family:"Arial","sans-serif"'>AJPM</span></em>, 14, 45-55 (2004).<o:p></o:p></p> <p>K.B. Johnson, T.D. Egan, S.E. Kern, S.W. McJames, M.L. Cluff, N.L. Pace,  Influence of Hemorrhagic Shock Followed by Crystalloid Resuscitation on Propofol: A Pharmacokinetic and Pharmacodynamic Analysis, <em><span style='font-family: "Arial","sans-serif"'>Anesthesiology</span></em>, 101, 647-59 (2004).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=SungWanKim4></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>Sung Wan Kim</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>S.Y. Chae, Y.Y. Kim, S.W. Kim, Y.H. Bae,  Prolonged Glucose Normalization of Streptozotocin-induced Diabetic Mice by Transplantation of Rat Islets Coencapsulated with Crosslinked Hemoglobin, <em><span style='font-family: "Arial","sans-serif"'>Transplantation</span></em>, 78, 392-397 (2004).<o:p></o:p></p> <p>J.S. Lee, M. Lee, S.W. Kim,  A New Potent hFIX Plasmid for Hemophilia B Gene Therapy, <em><span style='font-family:"Arial","sans-serif"'>Pharm. Res.</span></em>, 21, 1229-1232 (2004).<o:p></o:p></p> <p>C. Ahn , S.Y. Chae, Y.H. Bae, S.W. Kim,  Synthesis of Biodegradable Multi-Block Copolymers of Poly(L-Lysine) and Poly(ethylene glycol) as a Non-Viral Gene Carrier, <em><span style='font-family:"Arial","sans-serif"'>J. Control. Release</span></em>, 97, 567-574 (2004).<o:p></o:p></p> <p>D. Y. Furgeson, J.W. Yockman, M.-M. Janat, S.W. Kim,  Tumor Efficacy and Biodistribution of Linear Polyethylenimine-Cholesterol/DNA Complexes, <em><span style='font-family:"Arial","sans-serif"'>Molecular Therapy</span></em>, 9, 837-845 (2004).<o:p></o:p></p> <p>M.-M. Janat, J.W. Yockman, D. Furgeson, M. Lee, S. Kern, S.W. Kim,  Combination of Local, Nonviral IL-12 Gene Therapy and Systemic Paclitaxel Treatment in a Metastatic Breast Cancer Model, <em><span style='font-family:"Arial","sans-serif"'>Molecular Therapy</span></em>, 9, 829-836 (2004).<o:p></o:p></p> <p>M. Lee, M. Bikram, S. Oh, D.A. Bull, S.W. Kim,  Sp1-Dependent Regulation of the RTP801 Promoter and Its Application to Hypoxia-Inducible VEGF Plasmid for Ischemic Disease, <em><span style='font-family:"Arial","sans-serif"'>Pharm. Res.</span></em>, 21, 736-741 (2004).<o:p></o:p></p> <p>S. Choi, M. Baudys, S.W. Kim,  Control of Blood Glucose by Novel GLP-1 Delivery Using Biodegradable Triblock Copolymer of PLGA-PEG-PLGA in Type 2 Diabetic Rats, <em><span style='font-family:"Arial","sans-serif"'>Pharm. Res.</span></em>, 21, 827-831 (2004).<o:p></o:p></p> <p>M. Bikram, C.-H. Ahn, S.Y. Chae, M. Lee, J.W. Yockman, S.W. Kim,  Biodegradable Poly(ethylene glycol)-co-Poly(L-lysine)-g-histidine Multiblock Copolymers for Nonviral Gene Delivery, <em><span style='font-family:"Arial","sans-serif"'>Macromolecules</span></em>, 37, 1903-1916 (2004).<o:p></o:p></p> <p>Y.M. Kwon, S.W. Kim,  Biodegradable Triblock Copolymer Microspheres Based On Thermosensitive Sol-Gel Transition, <em><span style='font-family:"Arial","sans-serif"'>Pharm. Res.</span></em>, 21, 339-343 (2004).<o:p></o:p></p> <p>S.Y. Chae, M. Lee, S.W. Kim, Y.H. Bae,  Protection of Insulin Secreting Cells from Nitric Oxide Induced Cellular Damage by Crosslinked Hemoglobin, <em><span style='font-family:"Arial","sans-serif"'>Biomaterials</span></em>, 25, 843-850 (2004).<o:p></o:p></p> <p>J.H. Jeong, S.W. Kim, T.G. Park,  Biodegradable Triblock Copolymer of PLGA-PEG-PLGA Enhances Gene Transfection Efficiency, <em><span style='font-family:"Arial","sans-serif"'>Pharm. Res.</span></em>, 21, 50-54 (2004).<o:p></o:p></p> <p>M.M. Janat-Amsbury, J.W. Yockman, M. Lee, S. Kern, D.Y. Furgeson, M. Bikram, S.W. Kim,  Local, Non-Viral IL-12 Gene Therapy Using a Water Soluble Lipopolymer as Carrier System Combined with Systemic Paclitaxel for Cancer Treatment, <em><span style='font-family:"Arial","sans-serif"'>J. Control. Release</span></em>, 101, 273-285 (2005).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=JindrichKopecek4></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>JindYich Kope ek</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>A. David, P. Kope ková, T. Minko, A. Rubinstein, J. Kope ek,  Design of a Multivalent Galactoside Ligand for Selective Targeting of HPMA Copolymer-Doxorubicin Conjugates to Human Colon Cancer Cells, <em><span style='font-family:"Arial","sans-serif"'>Eur. J. Cancer</span></em>, 40, 148-157 (2004).<o:p></o:p></p> <p>D. Wang, W. Li, M. Pechar, P. Kope ková, D. Brömme, J. Kope ek,  Cathepsin K Inhibitor  Polymer Conjugates: Potential Drugs for the Treatment of Osteoporosis and Rheumatoid Arthritis, <em><span style='font-family:"Arial","sans-serif"'>Int. J. Pharm.</span></em>, 277, 73-79 (2004).<o:p></o:p></p> <p>A. Malugin, P. Kope ková, J. Kope ek,  HPMA Copolymer-Bound Doxorubicin Induces Apoptosis in Human Ovarian Carcinoma Cells by a Fas Independent Pathway, <em><span style='font-family:"Arial","sans-serif"'>Molecular Pharmaceutics</span></em>, 1, 174-182 (2004).<o:p></o:p></p> <p>D. Wang, S.C. Miller, M. Sima, D. Parker, H. Buswell, C. Goodrich, P. Kope ková, J. Kope ek,  The Arthrotropism of Macromolecules in Adjuvant Induced Arthritis Rat Model  A Preliminary Study, <em><span style='font-family: "Arial","sans-serif"'>Pharm. Res.</span></em>, 21, 1741-1749 (2004).<o:p></o:p></p> <p>J. Kope ek,  Genetically Engineered Protein Motifs in the Design of Novel Polymers and Drug Delivery Systems, In: <em><span style='font-family:"Arial","sans-serif"'>Contemporary Topics in Advanced Polymer Science and Technology</span></em>, (Q.-F. Zhou, S.Z.D. Cheng, Eds.), Peking University Press, pp. 374-386 (2004).<o:p></o:p></p> <p>P.D. Senter, J. Kope ek,  Drug Carriers in Medicine and Biology, <em><span style='font-family:"Arial","sans-serif"'>Molecular Pharmaceutics</span></em>, 1, 395-398 (2004).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=CarolLim4></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>Carol Lim</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>C. Kanwal, S. Mu, C.S. Lim,  Bidirectional On/Off Switch for Controlled Targeting of Proteins to Subcellular Compartments, <em><span style='font-family:"Arial","sans-serif"'>J. Control. Release</span></em>, 98(3), 379-393 (2004).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=ZhengRongLu4></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>Zheng-Rong Lu</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>Z.-R. Lu, D. L. Parker, K. C. Goodrich, J. Dalle, H. R. Buswell,  Extracellular Biodegradable Macromolecular Gadolinium(III) Complexes for Magnetic Resonance Imaging, <em><span style='font-family:"Arial","sans-serif"'>Magn. Reson. Med.</span></em>, 51, 27-34 (2004).<o:p></o:p></p> <p>A. M. Mohs, X. Wang, K. C. Goodrich, Y. Zong, D. L. Parker, Z.-R. Lu,  Poly(GdDTPA-L-cystine)-g-PEG: A Biodegradable Macromolecular Blood Pool Contrast Agent for MR Imaging, <em><span style='font-family:"Arial","sans-serif"'>Bioconjugate Chem.</span></em>, 15, 1424-1430 (2004).<o:p></o:p></p> <p>X. Wang, Y. Zong, K. C. Goodrich, D. L. Parker, Z.-R. Lu,  MR Imaging of Tumor Response to the Treatment with Anti-VEGF siRNA, <em><span style='font-family: "Arial","sans-serif"'>Molecular Imaging</span></em>, 3, 280, (2004).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=JohnMauger4></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>John Mauger</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>P.J. Missel, J.W. Mauger,  A Reinterpretation of the Concept of Intrinsic Dissolution in the Convective Diffusion/Dissolution Model, <em><span style='font-family:"Arial","sans-serif"'>AAPS Poster Presentation</span></em>, October 2004.<o:p></o:p></p> <p>J.W. Mauger,  Dissolution Performance Testing of USP Apparatus 2, <em><span style='font-family:"Arial","sans-serif"'>AAPS Workshop On Dissolution: New Technologies and Regulatory Initiatives</span></em>, March 2004.<o:p></o:p></p> <p>P.J. Missel, J.W. Mauger,  Dissolution of Anecortave Acetate In a Cylindrical Flow Cell- Re-evaluation of Convective Diffusion/Drug Dissolution for Sparingly Soluble Drugs, <em><span style='font-family:"Arial","sans-serif"'>Pharmaceutical Development and Technology</span></em>, 9, 453-459 (2004).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <o:p></o:p></p> <p class=deptname>2003 Publications:<a name=2003Publications1></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><a name=YouHanBae3></a><b><u><span style='font-family:"Arial","sans-serif";color:black'>You Han Bae</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>K.H. Park, Y.H. Bae, &quot;Phenotype of Hepatocyte Spheroids in Arg-Gly-Asp (RGD) Containing a Thermo-reversible Extracellular Matrix,&quot; <em><span style='font-family:"Arial","sans-serif"'>Biosci. Biotechnol. Biochem.</span></em>, 66, 1473-1478 (2002).<o:p></o:p></p> <p>S.I. Kang, Y.H. Bae, &quot;A Sulfonamide Based Glucose-responsive Hydrogel with Covalently Immobilized Glucose Oxidase and Catalase,&quot; <em><span style='font-family:"Arial","sans-serif"'>J. Controlled Release</span></em>, 86, 115-121 (2003).<o:p></o:p></p> <p>J.H. Park, Y.H. Bae, &quot;Hydrogels Based on Poly(ethylene oxide) and Poly(tetramethylene oxide) or Poly(dimethyl siloxane): III. In Vivo Biocompatibility and Biostability,&quot; <em><span style='font-family:"Arial","sans-serif"'>J. Biomed. Mater. Res.</span></em>, 64A, 309-319 (2003).<o:p></o:p></p> <p>S.K. Han, K. Na, Y.H. Bae, &quot;Sulfonamide Based pH-sensitive Polymeric Micelles: Physicochemical Characteristics and pH-dependent Aggregation,&quot; <em><span style='font-family:"Arial","sans-serif"'>Colloids and Surfaces A: Physicochem. Eng. Aspects</span></em>, 214, 49-59 (2003).<o:p></o:p></p> <p>K. Na, E.S. Lee, Y.H. Bae, &quot;Adriamycin Loaded Pullulan Acetate/sulfonamide Conjugate Nanoparticles Responding to Tumor pH: pH-dependent Cell Interaction, Internalization and Cytotoxicity In Vitro,&quot; <em><span style='font-family:"Arial","sans-serif"'>J. Controlled Release</span></em>, 87, 3-13 (2003).<o:p></o:p></p> <p>E.S. Lee, H. Shin, K. Na, Y.H. Bae, &quot;Poly(L-histidine)/PEG Block Copolymer Micelle and pH Induced Destabilization,&quot; <em><span style='font-family: "Arial","sans-serif"'>J. Controlled Release</span></em>, 90, 363-374 (2003).<o:p></o:p></p> <p>E.S. Lee, K. Na, Y.H. Bae, &quot;Polymeric Micelle for Tumor pH and Folate Mediated Targeting,&quot; <em><span style='font-family:"Arial","sans-serif"'>J. Controlled Release</span></em>, 91, 103-113 (2003).<o:p></o:p></p> <p>W.J. Sung, Y.H. Bae, &quot;A Glucose Oxidase Electrode Based on Polypyrrole with Polyanion/PEG/enzyme Conjugate Dopant: Effect of PEG Spacer Length and Synthetic Condition on the Response of the Enzyme Electrode,&quot; <em><span style='font-family:"Arial","sans-serif"'>Biosensors &amp; Bioelectronics</span></em>, 18, 1231-1239 (2003).<o:p></o:p></p> <p>J.H. Kim, S.K. Park, Y.H. Bae, &quot;In situ Manipulation of Degradation of Polyoxyethylene/poly(e-caprolactone) Multiblock Copolymer Hydrogel Implant,&quot; <em><span style='font-family:"Arial","sans-serif"'>J. Biomater. Sci. Polym. Ed.</span></em>, 14, 903-916 (2003).<o:p></o:p></p> <p>J.H. Park, Y.W. Cho, Y.-H. Cho, J.M. Choi, H.J. Shin, Y.H. Bae, H. Chung, S.Y. Jeong, I.C. Kwon, &quot;Norfloxacin-releasing Urethral Catheter for Long-term Catheterization,&quot; <em><span style='font-family:"Arial","sans-serif"'>J. Biomater. Sci. Polym. Ed.</span></em>, 14, 951-962 (2003).<o:p></o:p></p> <p>Y.W. Cho, J.H. Park, S.H. Kim, Y.-H. Cho, J.M. Choi, H.J. Shin, Y.H. Bae, H. Chung, S.Y. Jeong, I.C. Kwon, &quot;Gentamicin-releasing Urethral Catheter for Short-term Catheterization,&quot; <em><span style='font-family:"Arial","sans-serif"'>J. Biomater. Sci., Polym. Ed.</span></em>, 14, 963-972 (2003).<o:p></o:p></p> <p>J.H. Park, Y.H. Bae, &quot;Hydrogels Based on Poly(ethylene oxide) and Poly(tetramethylene oxide) or Poly(dimethyl siloxane): II. Physical Properties and Bacterial Adhesion,&quot; <em><span style='font-family:"Arial","sans-serif"'>J Appl. Polym. Sci.</span></em>, 89, 1505-1514 (2003).<o:p></o:p></p> <p>Y.S. Kim, J.H. Park, Y.H. Bae, &quot;Degradation and Stabilization of Cosmetic Polyetherurethane in Alcoholic Solution,&quot; <em><span style='font-family: "Arial","sans-serif"'>J. Appl. Polym. Sci.</span></em>, 89, 2270-2276 (2003).<o:p></o:p></p> <p>S. Kim, S.Y. Chae, K. Na, S.W. Kim, Y.H. Bae, &quot;Insulinotropic Activity of Sulfonylurea/pullulan Conjugate in Rat Islet Microcapsule,&quot; <em><span style='font-family:"Arial","sans-serif"'>Biomaterials</span></em>, 24, 4843-4851 (2003).<o:p></o:p></p> <p>Y.H. Bae, &quot;Smart Polymers in Drug Delivery,&quot; <em><span style='font-family: "Arial","sans-serif"'>Pharm. News</span></em>, 9, 417-424 (2002).<o:p></o:p></p> <p>D. Lee, S.-H. Lee, S. Kim, K. Char, J.H. Park, Y.H. Bae, &quot;Micro-phase-separation Behavior of Amphiphilic Polyurethanes Involving Poly(ethylene oxide) and Poly(tetramethylene oxide),&quot; <em><span style='font-family:"Arial","sans-serif"'>J. Polymer Sci. Part B. Polymer Phys.</span></em>, 41, 2365-2374 (2003).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=ThomasCheatham3></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>Thomas Cheatham</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>N. `pa ková, T. E. Cheatham, III, F. Ryjá ek, F. Lankaa, L. van Meervelt, P. Hobza, J. `poner,  Molecular Dynamics Simulations and Thermodynamics Analysis of DNA-drug Complexes. Minor Groove Binding Between 4'-6-diamino-2-phenylindole and DNA Duplexes in Solution, <i>J. Amer. Chem. Soc</i>., 125, 1759-1769 (2003).<o:p></o:p></p> <p>J. P. Lewis, T. E. Cheatham, III, H. Wang, E. Starikow, O. F. Sankey,  Dynamically Amorphous Character of Electronic States in poly(dA)-poly(dT) in DNA, <i>J. Phys. Chem. B</i>, 107, 2581-2587 (2003).<o:p></o:p></p> <p>R. `tefl, T. E. Cheatham, III, N. `pa ková, E. Fadrná, I. Berger, J. Ko a, J. `poner,  Folding Pathways of a Guanine-quadruplex DNA Revealed by Molecular Dynamics and Thermodynamical Analysis of the Substates, <i>Biophys. J</i>., 85, 1787-1804 (2003).<o:p></o:p></p> <p>F. Lankaa, J. `poner, J. Langowski, T. E. Cheatham, III,  DNA Base-pair Step Deformability Inferred from Molecular Dynamics Simulation, <i>Biophys. J</i>., 85, 2872-2883 (2003).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=JamesHerron3></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>James Herron</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>J.S. Cavenaugh, H.-K. Wang, C. Hansen, R. S. Smith, J. N. Herron,  How Well Can a T Cell Epitope Replace its Parent Carrier Protein? A dose response study, <i>Pharmaceutical Res.</i>, 20, 591-596 (2003).<o:p></o:p></p> <p>J.N. Herron, H.-K. Wang, V. Janatová, J. D. Durtschi, K. D. Caldwell, D. A. Christensen, I.-N. Chang, S.-C. Huang,  Orientation and Activity of Immobilized Antibodies, In: <i>Biopolymers at Interfaces</i>, 2<sup>nd</sup> Edition (M. Malmsten, ed.), Surfactant Science Series, Vol. 110, Marcel Dekker, New York, pp. 115-163 (2003).<o:p></o:p></p> <p>S.E. Tolley, H.-K. Wang, R. S. Smith, D. A. Christensen, J. N. Herron,  Single Chain Polymorphism Analysis in Long QT Syndrome using Planar Waveguide Fluorescent Biosensors, <i>Analytical Biochemistry</i>, 315, 223-237 (2003).<o:p></o:p></p> <p>A.-P. Wei, J. N. Herron (2003).  Assay Procedure Using Fluorogenic Tracers. U.S. Patent 6,576,419 (issued 6/10/2003).<o:p></o:p></p> <p>A.-P. Wei, J. N. Herron (2003).  Compositions and Kits for Fluorescence Polarization Assay of Large Molecules. U.S. Patent 6,632,613 (issued 10/14/2003).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=WilliamHiguchi3></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>William Higuchi</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>K. Tsutsumi, S.K. Li, A.-H. Ghanem, N.F.H. Ho, W.I. Higuchi,  A Systematic Examination of the In Vitro Using Chamber and the In Situ Single-Pass Perfusion Model Systems in Rat Ileum of Model Solutes, <i>J. Pharm. Sci</i>., 92, 344-359 (2003).<o:p></o:p></p> <p>A.H. Barry, H. Zhuang, A.A. Baig, W.I. Higuchi,  Effect of Fluoride Pretreatment on the Solubility of Synthetic Carbonated Apatite, <i>Calcif. Tissue Int</i>., 12, 236-242 (2003).<o:p></o:p></p> <p>D.S. Shaker, A-H. Ghanem, S.K. Li, K.S. Warner, F.M. Hashem, W.I. Higuchi,  Mechanistic Studies of the Effect of Hydroxypropyl-B-cyclodextrin on In Vitro Transdermal Permeation of Corticosterone through Hairless Mouse Skin, <i>Int. J. Pharm</i>., 253, 1-11 (2003).<o:p></o:p></p> <p>N. He, S.K. Li, T.M. Suhonen, K.S. Warner, W.I. Higuchi,  Mechanistic Study of Alkyl Azacycloheptanones as Skin Permeation Enhancers by Permeation and Partition Experiments with Hairless Mouse Skin, <i>J. Pharm. Sci</i>., 92, 297-310 (2003).<o:p></o:p></p> <p>K.S. Warner, S.K. Li, N. He, T.M. Suhonen, D. Chantasart, D. Bolikal, W.I. Higuchi,  Structure/Activity Relationship for Chemical Skin Permeation Enhancers: Probing the Chemical Microenvironment of the Site of Action, <i>J. Pharm. Sci</i>., 92, 1305-1322 (2003).<o:p></o:p></p> <p>H. Zhu, K.D. Peck, D.J. Miller, M.R. Liddell, G. Yan, W.I. Higuchi, S.K. Li,  Investigation of Properties of Human Epidermal Membrane under Constant Conductance Alternating Current Iontophoresis, <i>J. Controlled Release</i>, 89, 31-46 (2003).<o:p></o:p></p> <p>M. Otsuka, S. Morunaka, Y. Matsuda, A. Ito, H. Naito, N. Ichinose, T. Kokubo, T. Nakamura, W.I. Higuchi,  Effect of Particle Size on Zinc Release from Zinc Containing Tricalcium Phosphate (AnTCP) in Zn-Deficient Osteoporesis Rats, <i>Bio-Medical Materials and Engineering</i>, 13, 103-113 (2003).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=StevenKern3></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>Steven Kern</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>R.A. Lugo, S.E. Kern,  Clinical Pharmacokinetics of Morphine, <i>J. Pain Palliative Care Pharmacotherapy</i>, 16, 5-18 (2002).<o:p></o:p></p> <p>S.E. Kern, D. Jaron,  Healthcare Technology, Economics, and Policy: An Evolving Balance, <i>IEEE Eng. Med. Biol</i>., 22, 16-19 (2003).<o:p></o:p></p> <p>R.P. Huefner, N. Waitzman, J.D. Andrade, S.E. Kern,  For Cost Reducing Technologies, Knowing Markets it to Change Them, <i>IEEE Eng. Med. Biol</i>., 22, 26-31 (2003).<o:p></o:p></p> <p>K.B. Johnson, T.D. Egan, J. Layman, S.E. Kern, J.L. White, S. McJames,  The Influence of Hemorrhagic Shock on Etomidate: A Pharmacokinetic and Pharmacodynamic Analysis, <i>Anesth. Analg</i>., 96, 1360-1368 (2003).<o:p></o:p></p> <p>M. Lee, S.E. Kern, J. Kiskick, T.D. Egan,  Dose Titration with Multiple Oral Transmucosal Fentayl Citrate (OTFC) Units: A Bioequivalence Study, <i>J. Pain Symp.</i>, 26, 743-747 (2003).<o:p></o:p></p> <p>T.D. Egan, S.E. Kern, K.B. Johnson, N.L. Pace,  The Pharmacokinetics and Pharmacodynamics of Propofol in a Modified Cyclodextrin Formulation Versus Propofol in a Lipid Formulation: An Electroencephalographic and Hemodynamic Study in a Porcine Model, <i>Anesth. Analg</i>., 97, 72-79 (2003).<o:p></o:p></p> <p>K.B. Johnson, T.D. Egan, S.E. Kern, J.L. White, S. McJames, N. Syroid, D. Whiddon, T. Church,  The Influence of Hemorrhagic Shock on Propofol: A Pharmacokinetic and Pharmacodynamic Analysis, <i>Anesthesiology</i>, 99, 409-420 (2003).<o:p></o:p></p> <p class=MsoNormal style='margin:0in;margin-bottom:.0001pt'><a href="#top"><strong><span style='font-family:"Arial","sans-serif"'>(Back to the top)</span></strong></a> <a name=SungWanKim3></a><o:p></o:p></p> <p style='margin-bottom:0in;margin-bottom:.0001pt'><b><u><span style='font-family:"Arial","sans-serif";color:black'>Sung Wan Kim</span></u></b><span style='font-family:"Arial","sans-serif";color:black'><o:p></o:p></span></p> <p>D.-A. Wang, A.S. Narang, M. Kotb, A.O. Gaber, D.D. Miller, S.W. Kim, R.I. Mahato,  Novel Branched Poly(Ethylenimine)-Cholesterol Water-Soluble Lipopolymers for Gene Delivery, <i>Biomacromolecules</i>, 3, 1197-1207 (2002).<o:p></o:p></p> <p>Y.J. Park, J.F. Liang, K.S. Ko, S.W. Kim, V.C. Yang,  Low Molecular Weight Protamine as an Efficient and Nontoxic Gene Carrier: In Vitro Study, <i>J. Gene Medicine</i>, 5, 700-711 (2003).<o:p></o:p></p> <p>M. Lee, S.W. Kim,  Polymeric Gene Carriers, <i>Pharm. News</i>, 9, 407-415 (2003).<o:p></o:p></p> <p>M. Lee, J. Rentz, M. Bikram, S-O. Han, D.A. Bull, S.W. Kim,  Hypoxia-Inducible VEGF Gene Delivery to Ischemic Myocardium Using Water-soluble Lipopolymer, <i>Gene Therapy</i>, 10, 1535-1542 (2003).<o:p></o:p></p> <p>D.Y. Furgeson, W.S. Chan, J.W. Yockman, S.W. Kim,  Modified Linear Polyethylenimine-Cholesterol Conjugates for DNA Complexation, <i>Bioconjugate