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ADD Program Publications
- White HS, Sarup A, Bolvig T, Kristensen AS, Petersen G, Nelson N, Pickering DS, Larsson OM, Frolund B, Krogsgaard-Larsen P, Schousboe A.
Correlation between Anticonvulsant Activity and Inhibitory Action on Glial gamma-Aminobutyric Acid Uptake of the Highly Selective Mouse gamma-Aminobutyric Acid Transporter 1 Inhbitor 3-Hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and Its N-Alkylated Analogs
J Pharmacol Exp Ther. 2002 Aug;302(2):636-44
- Rho JM, Anderson GD, Donevan SD, White HS.
Acetoacetate, acetone, and dibenzylamine (a contaminant in 1-(+)-beta-hydroxybutyrate) exhibit direct anticonvulsant actions in vivo.
Epilepsia. 2002 Apr;43(4):358-61.
- Isoherranen N, White HS, Finnell RH, Yagen B, Woodhead JH, Bennett GD, Wilcox KS, Barton ME, Bialer.
Anticonvulsant profile and teratogenicity of N-methylcyclopropyl carboxamide: a new antiepileptic drug.
Epilepsia. 2002 Feb;43(2):115-26.
- Barton ME, Klein BD, Wolf HH, White HS.
Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy.
Epilepsy Res. 2001 Des;47(3):217-27.
- Skradski SL, Clark AM, Jiang H, White HS, Fu YH, Ptacek LJ.
A novel gene causing a mendelian audiogenic mouse epilepsy.
Neuron. 2001 Aug 30;31(4):537-44.
- Isoherranen N, Woodhead JH, White HS, Bialer M.
Anticonvulsant profile of valrocemide (TV1901): a new antiepileptic drug.
Epilepsia. 2001 Jul;42(7):831-6.
- Frankel WN, Taylor L, Beyer B, Tempel BL, White HS.
Elctroconvulsive threshholds of inbread mouse strains.
Genomics. 2001 Jun 15;74(3):306-12
- Moe ST, Smith DL, DelMar EG, Shimizu SM, Van Wagenen BC, Balandrin MF, Chien YE, Raszkiewicz JL, Artman LD, White HS, Mueller AL.
Chiral synthesis and pharmacological evaluation of NPS 1407: a potent,
stereoselective NMDA receptor antagonist.
Bioorg Med Chem Lett. 2000 Nov 6;10(21):2411-5.
- Skradski S, White HS.
Topiramate blocks kainate-evoked cobalt influx into cultured neurons.
Epilepsia. 2000;41 Suppl 1:S45-7.
- White HS, Brown SD, Woodhead JH, Skeen GA, Wolf HH.
Topiramate modulates GABA-evoked currents in murine cortical neurons by a
nonbenzodiazepine mechanism.
Epilepsia. 2000;41 Suppl 1:S17-20.
- Klein BD, White HS, Callahan KS.
Cytokine and intracellular signaling regulation of tissue factor expression in
astrocytes.
Neurochem Int. 2000 Apr;36(4-5):441-9.
- Falch E, Perregaard J, FrLlund B, SLkilde B, Buur A, Hansen LM, Frydenvang
K, Brehm L, Bolvig T, Larsson OM, Sanchez C, White HS, Schousboe A,
Krogsgaard-Larsen P.
Selective inhibitors of glial GABA uptake: synthesis, absolute stereochemistry,
and pharmacology of the enantiomers of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole (exo-THPO) and analogues.
J Med Chem. 1999 Dec 30;42(26):5402-14.
- White HS, McCabe RT, Armstrong H, Donevan SD, Cruz LJ, Abogadie FC, Torres J, Rivier JE, Paarmann I, Hollmann M, Olivera BM.
In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor
antagonist isolated from the venom of the fish-hunting snail Conus radiatus.
J Pharmacol Exp Ther. 2000 Jan;292(1):425-32.
- White HS.
Comparative anticonvulsant and mechanistic profile of the established and newer
antiepileptic drugs.
Epilepsia. 1999;40 Suppl 5:S2-10. Review.
- Hanson GR, Jensen M, Johnson M, White HS.
Distinct features of seizures induced by cocaine and amphetamine analogs.
Eur J Pharmacol. 1999 Jul 21;377(2-3):167-73.
- Salvati P, Maj R, Caccia C, Cervini MA, Fornaretto MG, Lamberti E,
Pevarello P, Skeen GA, White HS, Wolf HH, Faravelli L, Mazzanti M, Mancinelli E,
Varasi M, Fariello RG.
Biochemical and electrophysiological studies on the mechanism of action of
PNU-151774E, a novel antiepileptic compound.
J Pharmacol Exp Ther. 1999 Mar;288(3):1151-9.
- Snyder SR, Gerberich WW, White HS.
Scanning-tunneling-microscopy study of tip-induced transitions of
dislocation-network structures on the surface of highly oriented pyrolytic
graphite.
Phys Rev B Condens Matter. 1993 Apr 15;47(16):10823-10831
- Skradski SL, White HS, Ptacek LJ.
Genetic mapping of a locus (mass1) causing audiogenic seizures in mice.
Genomics. 1998 Apr 15;49(2):188-92.
- Rogers SW, Gahring LC, White HS.
Glutamate receptor GluR1 expression is altered selectively by chronic audiogenic
seizures in the Frings mouse brain.
J Neurobiol. 1998 May;35(2):209-16.
- Fariello RG, McArthur RA, Bonsignori A, Cervini MA, Maj R, Marrari P,
Pevarello P, Wolf HH, Woodhead JW, White HS, Varasi M, Salvati P, Post C.
Preclinical evaluation of PNU-151774E as a novel anticonvulsant.
J Pharmacol Exp Ther. 1998 May;285(2):397-403.
- White HS, Wolf HH, Woodhead JH, Kupferberg HJ.
The National Institutes of Health Anticonvulsant Drug Development Program:
screening for efficacy.
Adv Neurol. 1998;76:29-39. Review.
- White HS, Brown SD, Woodhead JH, Skeen GA, Wolf HH.
Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride
currents in murine brain neurons and increases seizure threshold.
Epilepsy Res. 1997 Oct;28(3):167-79.
- Rostock A, Tober C, Rundfeldt C, Bartsch R, Unverferth K, Engel J, Wolf HH, White HS.
AWD 140-190: a new anticonvulsant with a very good margin of safety.
Epilepsy Res. 1997 Jul;28(1):17-28.
- Bender AS, Woodbury DM, White HS.
The rapid L- and D-aspartate uptake in cultured astrocytes.
Neurochem Res. 1997 Jun;22(6):721-6.
- Carson JR, Carmosin RJ, Pitis PM, Vaught JL, Almond HR, Stables JP, Wolf
HH, Swinyard EA, White HS.
Aroyl(aminoacyl)pyrroles, a new class of anticonvulsant agents.
J Med Chem. 1997 May 23;40(11):1578-84.
- Baron BM, Harrison BL, Kehne JH, Schmidt CJ, van Giersbergen PL, White HS,
Siegel BW, Senyah Y, McCloskey TC, Fadayel GM, Taylor VL, Murawsky MK, Nyce P, Salituro FG.
Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site
antagonist.
Eur J Pharmacol. 1997 Apr 4;323(2-3):181-92.
- Kehne JH, Kane JM, Chaney SF, Hurst G, McCloskey TC, Petty MA, Senyah Y, Wolf HH, Zobrist R, White HS.
Preclinical characterization of MDL 27,192 as a potential broad spectrum
anticonvulsant agent with neuroprotective properties.
Epilepsy Res. 1997 Apr;27(1):41-54.
- Carter RB, Wood PL, Wieland S, Hawkinson JE, Belelli D, Lambert JJ, White
HS, Wolf HH, Mirsadeghi S, Tahir SH, Bolger MB, Lan NC, Gee KW.
Characterization of the anticonvulsant properties of ganaxolone (CCD 1042;
3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity,
steroid modulator of the gamma-aminobutyric acid(A) receptor.
J Pharmacol Exp Ther. 1997 Mar;280(3):1284-95.
- Gahring LC, White HS, Skradski SL, Carlson NG, Rogers SW.
Interleukin-1alpha in the brain is induced by audiogenic seizure.
Neurobiol Dis. 1997;3(4):263-9.
- White HS.
Clinical significance of animal seizure models and mechanism of action studies
of potential antiepileptic drugs.
Epilepsia. 1997;38 Suppl 1:S9-17. Review.
- Otto JF, Kimball MM, Wilcox KS.
Effects of the anticonvulsant retigabine on cultured cortical neurons: changes
in electroresponsive properties and synaptic transmission.
Mol Pharmacol. 2002 Apr;61(4):921-7.
- Kendrick SJ, Dichter MA, Wilcox KS.
Characterization of desensitization in recombinant N-methyl-D-aspartate
receptors: comparison with native receptors in cultured hippocampal neurons.
Brain Res Mol Brain Res. 1998 Jun 1;57(1):10-20.
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