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Anticonvulsant Drug Development Program |
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ADD Program PublicationsMouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization. J Physiol. 2008 Jul 15;586(14):3405-23. Epub 2008 May 15. PMID: 18483067 [PubMed - in process]
The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models. Epilepsia. 2008 Jul;49(7):1213-20. PMID: 18325020 [PubMed - in process]
Seizures following picornavirus infection. Epilepsia. 2008 Jun;49(6):1066-74. Epub 2008 Mar 6. PMID: 18325012 [PubMed - indexed for MEDLINE]
In vivo pharmacological effects of JZP-4, a novel anticonvulsant, in models for anticonvulsant, antimania and antidepressant activity.
In vivo pharmacological effects of JZP-4, a novel anticonvulsant, in models for anticonvulsant, antimania and antidepressant activity.
Seizures following picornavirus infection. Epilepsia. 2008 Jun;49(6):1066-74. Epub 2008 Mar 6. PMID: 18325012 [PubMed - indexed for MEDLINE]
Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization. J Physiol. 2008 May 15. [Epub ahead of print] PMID: 18483067 [PubMed - as supplied by publisher]
Traumatic brain injury during development reduces minimal clonic seizure thresholds at maturity. Epilepsy Res. 2008 May 17. [Epub ahead of print] PMID: 18490145 [PubMed - as supplied by publisher]
Inhibition of the betaine-GABA transporter (mGAT2/BGT-1) modulates spontaneous electrographic bursting in the medial entorhinal cortex (mEC). Epilepsy Res. 2008 Mar;79(1):6-13. Epub 2008 Feb 8. PMID: 18262393 [PubMed - indexed for MEDLINE]
Strain and age affect electroconvulsive seizure testing in rats.
Mechanisms of action of antiepileptic drugs. Int Rev Neurobiol. 2007;81:85-110. Review. PMID: 17433919 [PubMed - indexed for MEDLINE]
Phenytoin- and carbamazepine-resistant spontaneous bursting in rat entorhinal cortex is blocked by retigabine in vitro.
Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy.
Differential contribution of kainate receptors to excitatory postsynaptic currents in superficial layer neurons of the rat medial entorhinal cortex.
Differential contribution of kainate receptors to excitatory postsynaptic currents in superficial layer neurons of the rat medial entorhinal cortex.
A pharmacophore derived phenytoin analogue with increased affinity for slow inactivated sodium channels exhibits a desired anticonvulsant profile.
Hydroxyamide analogs of propofol exhibit state-dependent block of sodium channels in hippocampal neurons: implications for anticonvulsant activity.
Discovery of antiepileptic drugs Neurotherapeutics. 2007 Jan;4(1):12-7. Review. PMID: 17199014 [PubMed - indexed for MEDLINE]
Anticonvulsant activity, neural tube defect induction, mutagenicity and pharmacokinetics of a new potent antiepileptic drug, N-methoxy-2,2,3,3-tetramethylcyclopropane carboxamide. Epilepsy Res. 2007 Jan;73(1):75-84. Epub 2006 Sep 25. PMID: 16997532 [PubMed - indexed for MEDLINE]
A rat brain slice preparation for characterizing both thalamostriatal and corticostriatal afferents.
Felbamate is a subunit selective modulator of recombinant gamma-aminobutyric acid type A receptors expressed in Xenopus oocytes.
The antiepileptic and anticancer agent, valproic acid, induces P-glycoprotein in human tumour cell lines and in rat liver.
Preclinical evaluation of 2,2,3,3-tetramethylcyclopropanecarbonyl-urea, a novel, second generation to valproic acid, antiepileptic drug.
Effect of Conantokin G on NMDA receptor-mediated spontaneous EPSCs in cultured cortical neurons.
Subunit selectivity of topiramate modulation of heteromeric GABA(A) receptors.
Subunit selectivity of topiramate modulation of heteromeric GABA(A) receptors.
A spontaneous mutation involving Kcnq2 (Kv7.2) reduces M-current density and spike frequency adaptation in mouse CA1 neurons. J Neurosci. 2006 Feb 15;26(7):2053-9. PMID: 16481438 [PubMed - indexed for MEDLINE]
Basic research in epilepsy and aging.
Auditory deficits associated with the frings mgr1 (mass1) mutation in mice. Dev Neurosci. 2005;27(5):321-32. PMID: 16137990 [PubMed - indexed for MEDLINE]
Molecular pharmacology of topiramate: managing seizures and preventing migraine. Headache. 2005 Apr;45 Suppl 1:S48-56. Review. PMID: 15833090 [PubMed - indexed for MEDLINE]
First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2.
Correlation analysis between anticonvulsant ED50 values of antiepileptic drugs in mice and rats and their therapeutic doses and plasma levels. Epilepsy Behav. 2004 Dec;5(6):866-72. PMID: 15582834 [PubMed - indexed for MEDLINE]
Conantokins: peptide antagonists of NMDA receptors. Curr Med Chem. 2004 Dec;11(23):3073-84. Review. PMID: 15579001 [PubMed - indexed for MEDLINE]
c-Fos immunohistochemical mapping of the audiogenic seizure network and tonotopic neuronal hyperexcitability in the inferior colliculus of the Frings mouse. Epilepsy Res. 2004 Nov;62(1):13-25. PMID: 15519128 [PubMed - indexed for MEDLINE]
GABA transporters as drug targets for modulation of GABAergic activity. Biochem Pharmacol. 2004 Oct 15;68(8):1557-63. PMID: 15451399 [PubMed - indexed for MEDLINE]
Role of the betaine/GABA transporter (BGT-1/GAT2) for the control of epilepsy. Eur J Pharmacol. 2004 Oct 1;500(1-3):281-7. Review. PMID: 15464040 [PubMed - indexed for MEDLINE]
Mice carrying the szt1 mutation exhibit increased seizure susceptibility and altered sensitivity to compounds acting at the m-channel. Epilepsia. 2004 Sep;45(9):1009-16. PMID: 15329063 [PubMed - indexed for MEDLINE]
Mice carrying the szt1 mutation exhibit increased seizure susceptibility and altered sensitivity to compounds acting at the m-channel. Epilepsia. 2004 Sep;45(9):1009-16. PMID: 15329063 [PubMed - indexed for MEDLINE]
Differential effects of the anticonvulsant topiramate on neurobehavioral and histological outcomes following traumatic brain injury in rats. J Neurotrauma. 2004 May;21(5):501-12. PMID: 15165359 [PubMed - indexed for MEDLINE]
The effect of CGX-1007 and CI-1041, novel NMDA receptor antagonists, on NMDA receptor-mediated EPSCs. Epilepsy Res. 2004 Mar;59(1):13-24. PMID: 15135163 [PubMed - indexed for MEDLINE]
Metabolism of a new antiepileptic drug, N-methyl-tetramethylcyclopropanecarboxamide, and anticonvulsant activity of its metabolites. Epilepsy Res. 2004 Jan;58(1):1-12. PMID: 15066669 [PubMed - indexed for MEDLINE]
Modulation by topiramate of AMPA and kainate mediated calcium influx in cultured cerebral cortical, hippocampal and cerebellar neurons. Neurochem Res. 2004 Jan;29(1):275-82. PMID: 14992287 [PubMed - indexed for MEDLINE]
Therapy discovery for pharmacoresistant epilepsy and for disease-modifying therapeutics: summary of the NIH/NINDS/AES models II workshop.
Differences in multiple forms of short-term plasticity between excitatory and inhibitory hippocampal neurons in culture. Synapse. 2003 Oct;50(1):41-52. PMID: 12872293 [PubMed - indexed for MEDLINE]
Voltage-dependent block of N-methyl-D-aspartate receptors by the novel anticonvulsant dibenzylamine, a bioactive constituent of L-(+)-beta-hydroxybutyrate. Epilepsia. 2003 Oct;44(10):1274-9. PMID: 14510820 [PubMed - indexed for MEDLINE]
Pharmacokinetic-pharmacodynamic relationships of (2S,3S)-valnoctamide and its stereoisomer (2R,3S)-valnoctamide in rodent models of epilepsy. Pharm Res. 2003 Aug;20(8):1293-301. PMID: 12948028 [PubMed - indexed for MEDLINE]
Anticonvulsant activity, teratogenicity and pharmacokinetics of novel valproyltaurinamide derivatives in mice. Br J Pharmacol. 2003 Jun;139(4):755-64. PMID: 12812999 [PubMed - indexed for MEDLINE]
Different patterns of synaptic transmission revealed between hippocampal CA3 stratum oriens and stratum lucidum interneurons and their pyramidal cell targets Neuroscience. 2003;117(1):169-81. PMID: 12605903 [PubMed - indexed for MEDLINE]
Mechanism of action of newer anticonvulsants. J Clin Psychiatry. 2003;64 Suppl 8:5-8. PMID: 12892535 [PubMed - indexed for MEDLINE]
Preclinical development of antiepileptic drugs: past, present, and future directions. JEpilepsia. 2003;44 Suppl 7:2-8. Review. PMID: 12919332 [PubMed - indexed for MEDLINE]
Spontaneous deletion of epilepsy gene orthologs in a mutant mouse with a low electroconvulsive threshold. Hum Mol Genet. 2003 May 1;12(9):975-84. PMID: 12700166 [PubMed - indexed for MEDLINE]
Electroosmotic pore transport in human skin. Pharm Res. 2003 Apr;20(4):646-52. PMID: 12739774 [PubMed - indexed for MEDLINE]
Neuroimaging Markers of Epileptogenesis.
Characterization of the anticonvulsant profile and enantioselective pharmacokinetics of the chiral valproylamide propylisopropyl acetamide in rodents. Br J Pharmacol. 2003 Feb;138(4):602-13. PMID: 12598414 [PubMed - indexed for MEDLINE]
Evidence for functionally distinct synaptic NMDA receptors in ventromedial versus dorsolateral striatum. J Neurophysiol. 2003 Jan;89(1):69-80. PMID: 12522160 [PubMed - indexed for MEDLINE]
Models for epilepsy and epileptogenesis: report from the NIH workshop, Bethesda, Maryland. Epilepsia. 2002 Nov;43(11):1410-20. Review. PMID: 12423393 [PubMed - indexed for MEDLINE]
Animal models of epileptogenesis. Neurology. 2002 Nov 12;59(9 Suppl 5):S7-S14. Review. PMID: 12428026 [PubMed - indexed for MEDLINE]
Conantokin-L, a new NMDA receptor antagonist: determinants for anticonvulsant potency. Epilepsy Res. 2002 Sep;51(1-2):73-80. PMID: 12350383 [PubMed - indexed for MEDLINE]
Disease modification in partial epilepsy. Brain. 2002 Sep;125(Pt 9):1937-50. Review. PMID: 12183340 [PubMed - indexed for MEDLINE]
Effects of the anticonvulsant retigabine on cultured cortical neurons: changes in electroresponsive properties and synaptic transmission. Mol Pharmacol. 2002 Apr;61(4):921-7. PMID: 11901232 [PubMed - indexed for MEDLINE]
Anticonvulsant profile and teratogenicity of N-methyl-tetramethylcyclopropyl carboxamide: a new antiepileptic drug. Epilepsia. 2002 Feb;43(2):115-26. PMID: 11903457 [PubMed - indexed for MEDLINE]
Correlation between Anticonvulsant Activity and Inhibitory Action on Glial gamma-Aminobutyric Acid Uptake of the Highly Selective Mouse gamma-Aminobutyric Acid Transporter 1 Inhbitor 3-Hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and Its N-Alkylated Analogs J Pharmacol Exp Ther. 2002 Aug;302(2):636-44
Acetoacetate, acetone, and dibenzylamine (a contaminant in 1-(+)-beta-hydroxybutyrate) exhibit direct anticonvulsant actions in vivo. Epilepsia. 2002 Apr;43(4):358-61.
Anticonvulsant profile and teratogenicity of N-methylcyclopropyl carboxamide: a new antiepileptic drug. Epilepsia. 2002 Feb;43(2):115-26.
Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy. Epilepsy Res. 2001 Des;47(3):217-27.
A novel gene causing a mendelian audiogenic mouse epilepsy. Neuron. 2001 Aug 30;31(4):537-44.
Anticonvulsant profile of valrocemide (TV1901): a new antiepileptic drug. Epilepsia. 2001 Jul;42(7):831-6.
Elctroconvulsive threshholds of inbread mouse strains. Genomics. 2001 Jun 15;74(3):306-12
Chiral synthesis and pharmacological evaluation of NPS 1407: a potent, stereoselective NMDA receptor antagonist. Bioorg Med Chem Lett. 2000 Nov 6;10(21):2411-5.
Topiramate blocks kainate-evoked cobalt influx into cultured neurons. Epilepsia. 2000;41 Suppl 1:S45-7.
Topiramate modulates GABA-evoked currents in murine cortical neurons by a nonbenzodiazepine mechanism. Epilepsia. 2000;41 Suppl 1:S17-20.
Cytokine and intracellular signaling regulation of tissue factor expression in astrocytes. Neurochem Int. 2000 Apr;36(4-5):441-9.
Selective inhibitors of glial GABA uptake: synthesis, absolute stereochemistry, and pharmacology of the enantiomers of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole (exo-THPO) and analogues. J Med Chem. 1999 Dec 30;42(26):5402-14.
In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus. J Pharmacol Exp Ther. 2000 Jan;292(1):425-32.
Comparative anticonvulsant and mechanistic profile of the established and newer antiepileptic drugs. Epilepsia. 1999;40 Suppl 5:S2-10. Review.
Distinct features of seizures induced by cocaine and amphetamine analogs. Eur J Pharmacol. 1999 Jul 21;377(2-3):167-73.
Biochemical and electrophysiological studies on the mechanism of action of PNU-151774E, a novel antiepileptic compound. J Pharmacol Exp Ther. 1999 Mar;288(3):1151-9. Characterization of desensitization in recombinant N-methyl-D-aspartate receptors: comparison with native receptors in cultured hippocampal neurons. Brain Res Mol Brain Res. 1998 Jun 1;57(1):10-20. PMID: 9630479 [PubMed - indexed for MEDLINE]
Genetic mapping of a locus (mass1) causing audiogenic seizures in mice. Genomics. 1998 Apr 15;49(2):188-92.
Glutamate receptor GluR1 expression is altered selectively by chronic audiogenic seizures in the Frings mouse brain. J Neurobiol. 1998 May;35(2):209-16.
Preclinical evaluation of PNU-151774E as a novel anticonvulsant. J Pharmacol Exp Ther. 1998 May;285(2):397-403.
The National Institutes of Health Anticonvulsant Drug Development Program: screening for efficacy. Adv Neurol. 1998;76:29-39. Review.
Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold. Epilepsy Res. 1997 Oct;28(3):167-79.
AWD 140-190: a new anticonvulsant with a very good margin of safety. Epilepsy Res. 1997 Jul;28(1):17-28.
The rapid L- and D-aspartate uptake in cultured astrocytes. Neurochem Res. 1997 Jun;22(6):721-6.
Aroyl(aminoacyl)pyrroles, a new class of anticonvulsant agents. J Med Chem. 1997 May 23;40(11):1578-84.
Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist. Eur J Pharmacol. 1997 Apr 4;323(2-3):181-92.
Preclinical characterization of MDL 27,192 as a potential broad spectrum anticonvulsant agent with neuroprotective properties. Epilepsy Res. 1997 Apr;27(1):41-54.
Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor. J Pharmacol Exp Ther. 1997 Mar;280(3):1284-95.
Interleukin-1alpha in the brain is induced by audiogenic seizure. Neurobiol Dis. 1997;3(4):263-9.
Clinical significance of animal seizure models and mechanism of action studies of potential antiepileptic drugs. Epilepsia. 1997;38 Suppl 1:S9-17. Review.
Effects of the anticonvulsant retigabine on cultured cortical neurons: changes in electroresponsive properties and synaptic transmission. Mol Pharmacol. 2002 Apr;61(4):921-7.
Characterization of desensitization in recombinant N-methyl-D-aspartate receptors: comparison with native receptors in cultured hippocampal neurons. Brain Res Mol Brain Res. 1998 Jun 1;57(1):10-20.
Glycine regulation of synaptic NMDA receptors in hippocampal neurons. J Neurophysiol. 1996 Nov;76(5):3415-24. PMID: 8930282 [PubMed - indexed for MEDLINE]
Presence of mRNA for glutamic acid decarboxylase in both excitatory and inhibitory neurons. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9844-9. PMID: 8790419 [PubMed - indexed for MEDLINE]
Calcium-dependent paired-pulse facilitation of miniature EPSC frequency accompanies depression of EPSCs at hippocampal synapses in culture. J Neurosci. 1996 Sep 1;16(17):5312-23. PMID: 8757244 [PubMed - indexed for MEDLINE]
Properties of inhibitory and excitatory synapses between hippocampal neurons in very low density cultures. Synapse. 1994 Oct;18(2):128-51.
Scanning-tunneling-microscopy study of tip-induced transitions of dislocation-network structures on the surface of highly oriented pyrolytic graphite. Phys Rev B Condens Matter. 1993 Apr 15;47(16):10823-10831
M R Franklin PublicationsThe anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models.Epilepsia. 2008 Jul;49(7):1213-20.PMID: 18325020 [PubMed - indexed for MEDLINE]
Xenobiotic metabolism of plant secondary compounds in oak (Quercus agrifolia) by specialist and generalist woodrat herbivores, genus Neotoma.J Chem Ecol. 2007 Nov;33(11):2111-22. Epub 2007 Oct 11.PMID: 17929091 [PubMed - indexed for MEDLINE]
Comparative 1-substituted imidazole inhibition of cytochrome p450 isozyme-selective activities in human and mouse hepatic microsomes.Drug Metab Rev. 2007;39(2-3):309-22.PMID: 17786623 [PubMed - indexed for MEDLINE]
Enobiotic metabolism of plant secondary compounds in juniper (Juniperus monosperma) by specialist and generalist woodrat herbivores, genus Neotoma.Comp Biochem Physiol C Toxicol Pharmacol. 2007 Nov;146(4):552-60. Epub 2007 Jun 30.PMID: 17681888 [PubMed - indexed for MEDLINE]
Critical analysis of the waste management performance of two uranium production units in Brazil-part II: Caetite production center.J Environ Manage. 2008 Sep;88(4):914-25. Epub 2007 Jul 9.PMID: 17619076 [PubMed - in process]
Critical analysis of the waste management performance of two uranium production units in Brazil--part I: PoÁos de Caldas production centre.J Environ Manage.. 2008 Apr;87(1):59-72. Epub 2007 Jun 12.PMID: 17566635 [PubMed - indexed for MEDLINE]
Pre- and post-initiation chemoprevention activity of 2-alkyl/aryl selenazolidine-4(R)-carboxylic acids against tobacco-derived nitrosamine (NNK)-induced lung tumors in the A/J mouse.Chem Biol Interact. 2007 Jul 20;168(3):211-20. Epub 2007 May 4.PMID: 17543294 [PubMed - indexed for MEDLINE]
A porphomethene inhibitor of uroporphyrinogen decarboxylase causes porphyria cutanea tarda.Proc Natl Acad Sci U S A.. 2007 Mar 20;104(12):5079-84. Epub 2007 Mar 9.PMID: 17360334 [PubMed - indexed for MEDLINE]
The antimutagenicity of 2-substituted selenazolidine-4-(R)-carboxylic acids.Mutat Res. 2007 Mar 5;627(2):136-45. Epub 2006 Dec 12.PMID: 17166761 [PubMed - indexed for MEDLINE]
Hepatic chemoprotective enzyme responses to 2-substituted selenazolidine-4(R)-carboxylic acids.J Biochem Mol Toxicol. 2006;20(6):292-301.PMID: 17163488 [PubMed - indexed for MEDLINE]
Murine hepatoma (Hepa1c1c7) cells: a responsive in vitro system for chemoprotective enzyme induction by organoselenium compounds.Toxicol In Vitro. 2007 Feb;21(1):157-64. Epub 2006 Oct 7.PMID: 17110078 [PubMed - indexed for MEDLINE]
Acute effects of novel selenazolidines on murine chemoprotective enzymes.Chem Biol Interact. 2006 Jul 25;162(1):31-42.PMID: 16765927 [PubMed - indexed for MEDLINE]
Effect of selenium-containing compounds on hepatic chemoprotective enzymes in mice.Toxicology. 2006 Mar 15;220(2-3):179-88. Epub 2006 Jan 31.PMID: 16451816 [PubMed - indexed for MEDLINE]
Chemopreventive activity of selenocysteine prodrugs against tobacco-derived nitrosamine (NNK) induced lung tumors in the A/J mouse.J Biochem Mol Toxicol. 2005;19(6):396-405.PMID: 16421895 [PubMed - indexed for MEDLINE]
Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components.Drug Metab Dispos. 2003 Nov;31(11):1391-7.PMID: 14570772 [PubMed - indexed for MEDLINE]
Modulation of phase II drug metabolizing enzyme activities by N-heterocycles.Curr Drug Metab. 2002 Dec;3(6):599-607. Review.PMID: 12369888 [PubMed - indexed for MEDLINE]
Uroporphyria in the uroporphyrinogen decarboxylase-deficient mouse: Interplay with siderosis and polychlorinated biphenyl exposure.Hepatology. 2002 Oct;36(4 Pt 1):805-11.PMID: 12297827 [PubMed - indexed for MEDLINE] Cell-based studies reveal differences in glutathione S-transferase induction between oltipraz and tert-butylhydroquinone.J Biochem Mol Toxicol. 2002;16(4):154-61.PMID: 12242683 [PubMed - indexed for MEDLINE]
Accelerated development of uroporphyria in mice heterozygous for a deletion at the uroporphyrinogen decarboxylase locus.J Biochem Mol Toxicol. 2001;15(5):287-93.PMID: 11835626 [PubMed - indexed for MEDLINE]
The psoralens adversely affect reproductive function in male wistar rats.Reprod Toxicol. 2001 Mar-Apr;15(2):137-44.PMID: 11297873 [PubMed - indexed for MEDLINE]
A mouse model of familial porphyria cutanea tarda.Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):259-64.PMID: 11134514 [PubMed - indexed for MEDLINE] Transdermal estrogen replacement therapy in postmenopausal women previously treated for porphyria cutanea tarda.J Lab Clin Med. 2000 Dec;136(6):482-8.PMID: 11128750 [PubMed - indexed for MEDLINE]
CYP3A-inducing agents and the attenuation of uroporphyrin accumulation and excretion in a rat model of porphyria cutanea tarda.Biochem Pharmacol. 2000 Nov 1;60(9):1325-31.PMID: 11008126 [PubMed - indexed for MEDLINE]
Early events in the induction of rat hepatic UDP-glucuronosyltransferases, glutathione S-transferase, and microsomal epoxide hydrolase by 1,7-phenanthroline: comparison with oltipraz, tert-butyl-4-hydroxyanisole, and tert-butylhydroquinone.Drug Metab Dispos. 2000 Sep;28(9):1018-23.PMID: 10950843 [PubMed - indexed for MEDLINE]
Hemochromatosis genes and other factors contributing to the pathogenesis of porphyria cutanea tarda.Blood. 2000 Mar 1;95(5):1565-71.PMID: 10688809 [PubMed - indexed for MEDLINE] A novel group of ovarian toxicants: the psoralens.J Biochem Mol Toxicol. 1999;13(3-4):195-203.PMID: 10098905 [PubMed - indexed for MEDLINE]
Induction of drug metabolizing enzymes by 1,7-phenanthroline and oltipraz in mice is unrelated to Ah-responsiveness.J Biochem Mol Toxicol. 1999;13(2):77-82.PMID: 9890192 [PubMed - indexed for MEDLINE]
Drug-metabolizing enzyme induction by 2,2'-dipyridyl, 1,7-phenanthroline, 7,8-benzoquinoline and oltipraz in mouse.Xenobiotica. 1998 Oct;28(10):949-56.PMID: 9849642 [PubMed - indexed for MEDLINE]
Differential chemoprotection against acetaminophen-induced hepatotoxicity by latentiated L-cysteines.Chem Res Toxicol. 1998 Nov;11(11):1274-82.PMID: 9815187 [PubMed - indexed for MEDLINE] Phase II-selective induction of hepatic drug-metabolizing enzymes by oltipraz -5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione-, 1,7-phenanthroline, and 2,2'-dipyridyl in rats is not accompanied by induction of intestinal enzymes.Drug Metab Dispos. 1998 Feb;26(2):91-7.PMID: 9456293 [PubMed - indexed for MEDLINE]
Cytochrome P450 induction, uroporphyrinogen decarboxylase depression, porphyrin accumulation and excretion, and gender influence in a 3-week rat model of porphyria cutanea tarda.Toxicol Appl Pharmacol. 1997 Dec;147(2):289-99.PMID: 9439724 [PubMed - indexed for MEDLINE]
Intestinal UDP-glucuronosyltransferase activities in rat and rabbit.Xenobiotica. 1997 May;27(5):413-21.PMID: 9179984 [PubMed - indexed for MEDLINE]
Selective induction of phase II drug metabolizing enzyme activities by quinolines and isoquinolines.Chem Biol Interact. 1997 Mar 14;103(3):167-78.PMID: 9134007 [PubMed - indexed for MEDLINE] Mutational analysis of human uroporphyrinogen decarboxylase.Biochim Biophys Acta. 1996 Dec 5;1298(2):294-304.PMID: 8980654 [PubMed - indexed for MEDLINE] Effect of total parenteral nutrition containing lipid calories on hepatic drug metabolism in rats.Drug Metab Dispos. 1996 Apr;24(4):502-5. No abstract available. PMID: 8801067 [PubMed - indexed for MEDLINE]
Correlations of the induction of microsomal epoxide hydrolase activity with phase II drug conjugating enzyme activities in rat liver.Toxicol Lett. 1996 Apr;85(1):29-34.PMID: 8619256 [PubMed - indexed for MEDLINE]
Effect of lipid-free total parenteral nutrition on hepatic drug conjugation in rats.J Pharmacol Exp Ther. 1996 Feb;276(2):602-8.PMID: 8632327 [PubMed - indexed for MEDLINE]
Drug metabolizing enzyme induction by benzoquinolines, acridine, and quinacrine; tricyclic aromatic molecules containing a single heterocyclic nitrogen.J Biochem Toxicol. 1996;11(6):297-303.PMID: 9176741 [PubMed - indexed for MEDLINE] Enhanced rates of cytochrome P450 metabolic-intermediate complex formation from nonmacrolide amines in rifampicin-treated rabbit liver microsomes.Drug Metab Dispos. 1995 Dec;23(12):1379-82.PMID: 8689947 [PubMed - indexed for MEDLINE] The depression of hepatic drug conjugation reactions in rats after lipid-free total parenteral nutrition administered via the portal vein.JPEN J Parenter Enteral Nutr. 1995 Jul-Aug;19(4):303-9.PMID: 8523630 [PubMed - indexed for MEDLINE]
Induction of rat liver drug-metabolizing enzymes by heterocycle-containing mono-, di-, tri- and tetra-arylmethanes.Biochem Pharmacol. 1993 Aug 17;46(4):683-9.PMID: 8363642 [PubMed - indexed for MEDLINE]
Hepatic clotrimazole concentrations and hepatic drug metabolizing enzyme activities in adult male Sprague-Dawley rats.Toxicology. 1993 Jun 4;80(1):27-35.PMID: 8322370 [PubMed - indexed for MEDLINE]
Selective induction of rat liver phase II enzymes by N-heterocycle analogues of phenanthrene: a response exhibiting high correlation between UDP-glucuronosyltransferase and microsomal epoxide hydrolase activities.Xenobiotica. 1993 Mar;23(3):267-77.PMID: 8498089 [PubMed - indexed for MEDLINE] N-benzylimidazole-mediated changes in hepatic drug-metabolizing enzyme activities in Ah-responsive and Ah-non-responsive mice.Xenobiotica. 1992 Dec;22(12):1395-402.PMID: 1494885 [PubMed - indexed for MEDLINE] Concomitant induction of microsomal epoxide hydrolase and UDP-glucuronosyltransferase activities by dipyridine compounds.Drug Metab Dispos. 1992 Sep-Oct;20(5):726-9.PMID: 1358578 [PubMed - indexed for MEDLINE]
Changes in conjugative enzyme activity and acetaminophen metabolism in young and senescent male F-344 rats following prolonged exposure to buthionine sulfoximine.Exp Gerontol. 1992;27(2):221-32.PMID: 1521595 [PubMed - indexed for MEDLINE]
Whether cytochrome P450 induction accompanies glucuronosyl and glutathione transferase induction by isomers of dipyridyl appears unrelated to dose and iron chelation properties.J Biochem Toxicol. 1992 Summer;7(2):81-5.PMID: 1404246 [PubMed - indexed for MEDLINE]
Drug metabolizing enzyme induction by simple diaryl pyridines; 2-substituted isomers selectively increase only conjugation enzyme activities, 4-substituted isomers also induce cytochrome P450.Toxicol Appl Pharmacol. 1991 Oct;111(1):24-32.PMID: 1949033 [PubMed - indexed for MEDLINE] |
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