Steve Bealer
Professor of Pharmacology and Toxicology
Title: Professor of Pharmacology and Toxicology
Email address: steve.bealer@deans.pharm.utah.edu
Education and Training:
- B.S. 1971, University of Wyoming
- Ph.D. 1976, University of Wyoming
Research Interests:
One series of ongoing studies is directed at understanding the effects of seizure disorders on heart function and the increased risk of sudden cardiac death, using an animal model of status epilepticus and temporal lobe epilepsy. A separate line of investigation is aimed at understanding the mechanisms through which these seizure disorders disrupt ovarian hormone secretion and energy balance in female rats.
Selected Publications:
- Bealer, S.L. Metcalf, C.S., Little, J.G., Vatta, M., Brewster, A., and Andersen, A.E. Sympathetic nervous system dysregulation of cardiac function and myocyte potassium channel remodeling in rodent seizure disorders: Candidate mechanisms for SUDEP. In; Lathers, C.M., Schraeder, P.L., Bungo, M.W. and Leestma, J.E. (Eds), Sudden Death in Epilepsy: Forensic and Clinical Issues. Taylor and Francis Group, LLC, Boca Raton, FL, In Press
- Metcalf, C.S., Poelzing, S., Little, J.G., and Bealer, S.L. Status epilepticus induces cardiac myofilament damage and increased susceptibility to arrhythmias in rats. American Journal of Physiology: Heart and Circ. Physiology In press.
- Metcalf, C.S., Radwanski, P., Bealer, S.L. Status epilepticus produces chronic alterations in cardiac sympathovagal balance. Epilepsia 50, 747-754, 2009.
- Tereyuma, R., Lipschitz, D.L., Wang, L., Ramoz, G., Crowley, W.R., Bealer, S.L., and Armstrong, W.E. Central blockade of oxytocin receptors during mid-late gestation reduces amplitude of slow afterpolarization in supraoptic neurons. American Journal of Physiology 295, E1167-E1171, 2008.
- Lipschitz, D.L., Crowley, R.W. and Bealer, S.L. Differential sensitivity of intranuclear and systemic oxytocin release to central noradrenergic receptor stimulation during mid- and late gestation in rats. American Journal of Physiology (Endocrinology and Metabolism) 287: E523-E528, 2004.
- Bealer, S.L. and Metcalf, C.S.. Increased dietary sodium enhances activation of neurons in the medullary cardiovascular pathway during acute sodium loading in the rat. Autonomic Neuroscience 117: 33-40, 2005.
- Bealer, S.L. Increased dietary sodium inhibits baroreflex-induced bradycardia during acute sodium loading. American Journal of Physiology (Regulatory, Integrative and Comparative Physiology). 288: R1211-R1219, 2005.
- Bealer, S.L., Lipschitz, D.L., Ramoz, G., Crowley, R.W. Oxytocin receptor binding in magnocellular nuclei during gestation in rats. American Journal of Physiology: Reg., Int., and Comp. Physiol. 291, R53-R58, 2006.
- Bealer, S.L., Metcalf, C.S., and Heyborne, R. Increased dietary sodium alters Fos expression in the lamina terminalis during intravenous angiotensin II infusion. Experimental Neurology 204, 299-306, 2007.
