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Paul S. Frankel

Research Assistant Professor of Pharmacology and Toxicology

Education and Training

B.A. 1994, Ithaca College

Ph.D. 1999, Tulane University

Post-doctoral Fellow 1999 - 2003, University of Texas Medical Branch, Galveston, Texas.

Research Interests

Research in our lab focuses upon the psychopharmacology responsible for the mechanisms underlying drug abuse, drug addiction and drug toxicity. Through incorporation of neuroanatomical and neurochemical techniques, our current goals are to elucidate the roles played by neurotransmitter receptors (dopamine and serotonin) and opioid peptides in modulating the effects of contingent administration of psychostimulants (e.g. methamphetamine, cocaine).

Publications

Frankel PS, Hoonakker AJ, Hanson GR. Differential response to methamphetamine self-administration: Role of contingency. (submitted).

Frankel PS, Alburges ME, Bush L, Hanson GR, Kish SJ (2007) Brain levels of neuropeptides in human chronic methamphetamine users. Neuropharmacology, 53: 447-454.

Frankel PS, Hoonakker AJ, Danaceau JP, Hanson GR (2007) Mechanism of an exaggerated locomotor response to a low-dose challenge of methamphetamine. Pharmacology, Biochemistry and Behavior, 86: 511-515.

Ross JD, Herin DV, Frankel PS, Thomas ML, Cunningham KA (2006) Chronic treatment with a serotonin2 receptor (5-HT2T) agonist modulates the behavioral and cellular response to (+)-3,4-methylenedioxymethamphetamine [(+)-MDMA].

Frankel PS, Hoonakker AJ, Hanson GR, Bush L, Keefe KA, Alburges ME (2005) Differential neurotensin response to low and high doses of methamphetamine in the terminal regions of striatal efferents. European Journal of Pharmacology, 522: 47-54.

Pharmacology & Toxicology   College of Pharmacy   30 S. 2000 E., Rm 201, SLC  UT 84112  phone: 801-581-6287  fax: 801-585-5111 phtx@pharm.utah.edu