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Glen R. Hanson

Professor of Pharmacology and Toxicology

Education and Training

D.D.S. 1973, University of California, Los Angeles

Ph.D. 1978, University of Utah, Pharmacology

PRAT Fellow 1978-1980, National Institutes of Health, Bethesda, Maryland

Research Interests

Dr. Hanson's research objectives are to elucidate the basis for neurological and psychiatric disorders. He is particularly experienced in the neurochemical analysis of the brain, with an emphasis on the monoamines (i.e., dopamine, serotonin and norepinephrine) and neuropeptides (i.e., enkephalins, dynorphin, substance P, neurotensin, neuropeptide Y). His studies have demonstrated that dramatic changes occur in both monoamine and neuropeptide systems after in vivo treatment with potent stimulants of abuse, such as the amphetamines and cocaine. It is believed that identification of the mechanistic and functional significance of these neurochemical responses to the stimulants will provide important insight into diseases such as Parkinson's disease, Huntington's chorea, psychosis in general and schizophrenia in particular, and drug abuse.

Selected Publications

Volz, TJ, Farnsworth, SM., King, JL, Riddle, EL, Hanson, GR, and Fleckenstein, A.E.: Methyphenidate administration alters vesicular monoamine transporter-2 function in cytoplasmic and membrane-associated vesicles. J. Pharmacol. Exp. Ther. (2007) in press.

Alburges, M.E., Hoonakker, A.J., and Hanson, G.R.: Nicotinic and dopamine D(2) receptors mediate nicotine-induced changes in ventral tegmental area neurotensin system. Eur. J. Pharmacol. 573 (2007) 124-132.

Frankel, P.S., Alburges, M.E., Bush, L., Hanson, G.R. and Kish, S.J.: Brain levels of neuropeptides in human chronic methamphetamine users. Neuropharmacology 53 (2007) 447-454.

Volz, T., Fleckenstein, A. and Hanson, G.R.: Methamphetamine-induced alterations in monoamine transport: implications for neurotoxicity, neuroprotection and treatment. Addiction 102 (suppl. 1) (2007) 44-48.

Frankel PS, Hoonakker AJ, Danaceau JP, Hanson GR. Mechanism of an exaggerated locomotor response to a low-dose challenge of methamphetamine.. Pharmacol Biochem Behav. 86 (2007) 511-515.

Volz, T., Hanson, G.R., and Fleckenstein, A.E.: The role of plasmalemmal dopamine and vesicular monoamine transporters in methamphetamine-induced dopaminergic deficits. J. Neurochem. (2007).

Fleckenstein, A.E., Volz, T., Riddle, E., Gibb, J.W., and Hanson, G.R.: New insights into the mechanism of action of amphetamines. Ann. Rev. Pharmacol. Tox. 47 (2007) 681-698.

Pharmacology & Toxicology   College of Pharmacy   30 S. 2000 E., Rm 201, SLC  UT 84112  phone: 801-581-6287  fax: 801-585-5111 phtx@pharm.utah.edu