Glen Hanson
Professor of Pharmacology and Toxicology
Title: Professor of Pharmacology and Toxicology
Email address: g.r.h@pharm.utah.edu
Education and Training:
- D.D.S. 1973, University of California, Los Angeles
- Ph.D. 1978, University of Utah, Pharmacology
- PRAT Fellow 1978-1980, National Institutes of Health, Bethesda, Maryland
Research Interests:
Dr. Hanson's research objectives are to elucidate the basis for neurological and psychiatric disorders. He is particularly experienced in the neurochemical analysis of the brain, with an emphasis on the monoamines (i.e., dopamine, serotonin and norepinephrine) and neuropeptides (i.e., enkephalins, dynorphin, substance P, neurotensin, neuropeptide Y). His studies have demonstrated that dramatic changes occur in both monoamine and neuropeptide systems after in vivo treatment with potent stimulants of abuse, such as the amphetamines and cocaine. It is believed that identification of the mechanistic and functional significance of these neurochemical responses to the stimulants will provide important insight into diseases such as Parkinson's disease, Huntington's chorea, psychosis in general and schizophrenia in particular, and drug abuse.
Selected Publications:
- Hadlock, G.C., Baucum, A.J. 2nd, King, J.L., Horner, K.A., Cook, G.A., Gibb, J.W., Wilkins, D.G., Hanson, G.R. , and Fleckenstein, A.E.: Mechanisms underlying methamphetamine-induced dopamine transporter complex formation. J. Pharmacol. Exp. Ther. 329 (2009) 169-74.
- Hanson, J.E., Birdsall, E., Seferian, K., Crosby, M., Keefe, Dristen, Gibb, J., Hanson, G.R. , and Fleckenstein, A.E.: Methamphetamine-induced dopaminergic deficits and refractoriness to subsequent treatment. Eur. J. Pharmacol. 607 (2009) 68-73.
- Farnsworth, S.J., Volz, T.J., Hanson, G.R. , and Fleckenstein, A.E..: Cocaine alters vesicular dopamine sequestration and Potassium-stimulated dopamine release: The role of D2 receptor activation. J. Pharmacol. Exp. Ther. 328 (2009) 1-6.
- Volz, T.J., Farnsworth, S.J, Hanson, G.R, and Fleckenstein, A.E.: Method development and validation of an in vitro model of the effects of methylphenidate on membrane-associated synaptic vesicles. J Neurosci Methods. 177 (2009) 177-182.
- Volz, T.J., Farnsworth, S.J., Hanson, G.R. , and Fleckenstein, A.E.: Measurement of plasmalemmal dopamine transport, vesicular dopamine transport, and K(+)-stimulated dopamine release in frozen rat brain tissue. J Neurosci Methods. 2009 Jun 15;180 (2):317-20. Epub 2009 Mar 28
- Alburges, M.E., Frankel, P.S., Hoonakker, A.J., Hanson, G.R. : Responses of limbic and extrapyramidal substance P systems to nicotine treatment. Psychopharmacology (Berl) 201 (2009) 517-527.
- Volz, T.J., Farnsworth, S.J., Rowley, S.D., Hanson, G.R. , and Fleckenstein: Age-dependent differences in dopamine transporter and vesicular monoamine transporter-2 function and their implications for methamphetamine neurotoxicity. Synapse 63 (2009) 147-51.
- Fleckenstein, A.E., Volz, T.J. and Hanson, G.R. : Psychostimulant-induced alterations in vesicular monoamine transporter-2 function: neurotoxic and therapeutic implications. Neuropharmacology 56 (2009) 133-138.
- Volz, TJ, Farnsworth, SM., King, JL, Riddle, EL, Hanson, GR, and Fleckenstein, A.E.: Methyphenidate administration alters vesicular monoamine transporter-2 function in cytoplasmic and membrane-associated vesicles. J. Pharmacol. Exp. Ther. (2007) in press.
- Alburges, M.E., Hoonakker, A.J., and Hanson, G.R.: Nicotinic and dopamine D(2) receptors mediate nicotine-induced changes in ventral tegmental area neurotensin system. Eur. J. Pharmacol. 573 (2007) 124-132.
- Frankel, P.S., Alburges, M.E., Bush, L., Hanson, G.R. and Kish, S.J.: Brain levels of neuropeptides in human chronic methamphetamine users. Neuropharmacology 53 (2007) 447-454.
- Volz, T., Fleckenstein, A. and Hanson, G.R.: Methamphetamine-induced alterations in monoamine transport: implications for neurotoxicity, neuroprotection and treatment. Addiction 102 (suppl. 1) (2007) 44-48.
- Frankel PS, Hoonakker AJ, Danaceau JP, Hanson GR. Mechanism of an exaggerated locomotor response to a low-dose challenge of methamphetamine.. Pharmacol Biochem Behav. 86 (2007) 511-515.
- Volz, T., Hanson, G.R., and Fleckenstein, A.E.: The role of plasmalemmal dopamine and vesicular monoamine transporters in methamphetamine-induced dopaminergic deficits. J. Neurochem. (2007).
- Fleckenstein, A.E., Volz, T., Riddle, E., Gibb, J.W., and Hanson, G.R.: New insights into the mechanism of action of amphetamines. Ann. Rev. Pharmacol. Tox. 47 (2007) 681-698.
Complete Biosketch:
