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Matthew H. Slawson

Research Assistant Professor of Pharmacology and Toxicology

Education and Training

B.S., 1990, University of Utah

Ph.D., 1997, University of Utah

Research Interests

As an investigator with the Center for Human Toxicology, Dr. Slawson is interested in the forensic, applied and research applications of liquid chromatography and atmospheric pressure ionization mass spectrometry and tandem mass spectrometry (MS/MS). A particular focus is the development of sensitive and specific analytical methods for the detection of trace amounts of drug and drug metabolites in biological matrices such as urine and blood. These methods are then used in support of research into the treatment of drug addiction. Additionally, Dr. Slawson is interested in the forensic and clinical applications of detecting drugs and drug metabolites in alternative matrices such as hair, saliva and sweat.

Selected Publications

Slawson, M.H., Wilkins, D.G., and Rollins, D.E. The incorporation of drugs into hair: Relationship of hair color and melanin concentration to phencyclidine concentration. Journal of Analytical Toxicology 22: 406-413, 1998.

Slawson, M.H., Crouch, D.J., Andrenyak, D., Rollins, D.E., Lu, J.K., and Bailey, P.L. Determination of morphine, morphine-3-glucuronide, and morphine-6-glucuronide in plasma after intravenous and intrathecal morphine administration using HPLC with electrospray ionization and tandem mass spectrometry. Journal of Analytical Toxicology 23: 468-473, 1999.

P.L. Bailey, J.K. Lu, N.L. Pace, J.A. Orr, J.L. White, E.A. Hamber, M.H. Slawson, D.J. Crouch, D.E. Rollins. Effects of intrathecal morphine on the ventilatory response to hypoxia. The New England Journal of Medicine, 343: 1228-1234, 2000.

D.J. Crouch and M.H. Slawson. Analysis of selected low-dose benzodiazepines by mass spectrometry. In: Forensic Science and Medicine; Benzodiazepines and GHB: detection and pharmacology. S. Salamone, Ed. Humana Press, Totowa, N.J. 2001.

T. C. Kupiec and M.H. Slawson. High pressure liquid chromatography. In: Clarke's Isolation and Identification of Drugs (4th edition), The Pharmaceutical Press, In Review, May 2002.

M.H. Slawson, J.L. Taccogno, R.L. Foltz, D.E. Moody. Quantitative analysis of selegiline and three metabolites (N-desmethylselegiline, methamphetamine and amphetamine) by HPLC-APCI-MS/MS in human plasma. Journal of Analytical Toxicology, In Press, 2002.

Pharmacology & Toxicology   College of Pharmacy   30 S. 2000 E., Rm 201, SLC  UT 84112  phone: 801-581-6287  fax: 801-585-5111 phtx@pharm.utah.edu